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Molecule Parameter List for L.EGFR | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by  color. | | Statistics |
Accession and Pathway Details | |
| Accession Name | Accession No. | Accession Type | Pathway Link | | fig2_egfr | 1 | Network |
Shared_Object_fig2_egfr, PKC, PLA2,
PLCbeta, Gq, MAPK,
Ras, EGFR, Sos,
PLC_g, CaRegulation | This network was used to generate figure 2 in Bhalla US and Iyengar R. Science (1999) 283(5400):381-7. It consists of the MAPK cascade in a feedback loop with PKC, and receives input from the EGFR in the synapse.
Demonstration script files for generating the figures in the paper, including figure 2, are available here. |
L.EGFR acting as a Molecule in fig2_egfr Network
| Name | Accession Name | Pathway Name | Initial Conc.
(uM) | Volume
(fL) | Buffered | | L.EGFR | fig2_egfr
Accession No. : 1 | EGFR
Pathway No. : 8 | 0 | 1000 | No | | |
L.EGFR acting as an Enzyme in fig2_egfr Network
| | Enzyme Molecule /
Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents | | 1 | L.EGFR /
phosph_PLC_g
| fig2_egfr
Accession No. : 1 | EGFR
Pathway No. : 8 | 0.333333 | 0.2 | 4 | explicit E-S complex | Substrate
Ca.PLC_g
Product
Ca.PLC_g*
| | 2 | L.EGFR /
phosph_Shc
| fig2_egfr
Accession No. : 1 | EGFR
Pathway No. : 8 | 0.833333 | 0.2 | 4 | explicit E-S complex | Substrate
SHC
Product
SHC*
|
L.EGFR acting as a Substrate in a reaction in fig2_egfr Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | | Internalize | fig2_egfr
Accession No. : 1 | EGFR
Pathway No. : 8 | 0.002
(s^-1) | 0.0003
(s^-1) | Keq = 0.165(uM) | 434.783sec | Substrate
L.EGFR
Product
Internal_L.EGFR
|
L.EGFR acting as a Product in a reaction in fig2_egfr Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | | act_EGFR | fig2_egfr
Accession No. : 1 | EGFR
Pathway No. : 8 | 4.2
(uM^-1 s^-1) | 0.25
(s^-1) | Kd(bf) = 0.0595(uM) | - | Substrate
EGF
EGFR
Product
L.EGFR
|
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
This Copyright is applied to ensure that the contents of this database remain freely available. Please see FAQ for details. |
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