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Molecule Parameter List for CaM(Ca)n-CaNAB | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by  color. | | Statistics |
| CaM(Ca)n-CaNAB participated as | Molecule | Sum total of | Enzyme | Substrate of an enzyme | Product of an enzyme | Substrate in Reaction | Product in Reaction | | No. of occurrences | 1 | 1 | 3 | 0 | 0 | 0 | 0 |
Accession and Pathway Details | |
| Accession Name | Accession No. | Accession Type | Pathway Link | Synaptic_
Network | 16 | Network |
Shared_Object_Synaptic_Network, PKC, PLA2,
PLCbeta, Gq, MAPK,
Ras, EGFR, Sos,
PLC_g, CaMKII, CaM,
PP1, PP2B, PKA,
AC, CaRegulation | This model is an annotated version of the synaptic signaling network.
The primary reference is Bhalla US and Iyengar R. Science (1999) 283(5400):381-7 but several of the model pathways have been updated.
Bhalla US Biophys J. 2002 Aug;83(2):740-52
Bhalla US J Comput Neurosci. 2002 Jul-Aug;13(1):49-62 |
CaM(Ca)n-CaNAB acting as a Molecule in Synaptic_Network Network
| Name | Accession Name | Pathway Name | Initial Conc.
(uM) | Volume
(fL) | Buffered | | CaM(Ca)n-CaNAB | Synaptic_
Network
Accession No. : 16 | Shared_Object_
Synaptic_
Network
Pathway No. : 70 | 0 | 1000 | No | | This pool sums the levels of the CaM.Ca2.CaNAB, CaM.Ca3.CaNAB and CaM.Ca4.CaNAB pools. |
CaM(Ca)n-CaNAB acting as a Summed Molecule in Synaptic_Network Network
CaM(Ca)n-CaNAB acting as an Enzyme in Synaptic_Network Network
| | Enzyme Molecule /
Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents | | 1 | CaM(Ca)n-CaNAB /
dephosph_
neurogranin
| Synaptic_
Network
Accession No. : 16 | Shared_Object_
Synaptic_
Network
Pathway No. : 70 | 10.012 | 0.67 | 3.98507 | explicit E-S complex | Substrate
neurogranin*
Product
neurogranin
| | | From Seki et al ABB 316(2):673-679 | | 2 | CaM(Ca)n-CaNAB /
dephosph_inhib1
| Synaptic_
Network
Accession No. : 16 | Shared_Object_
Synaptic_
Network
Pathway No. : 70 | 4.97076 | 0.34 | 4 | explicit E-S complex | Substrate
I1*
Product
I1
| | | Assume the rates are the same when dephosphorylating I1 either when it is floating freely, or when it is bound to PP1 catalytic subunit. This is from Liu and Storm 1989 264(22):12800-12804 | | 3 | CaM(Ca)n-CaNAB /
dephosph-PP1-I*
| Synaptic_
Network
Accession No. : 16 | Shared_Object_
Synaptic_
Network
Pathway No. : 70 | 4.97076 | 0.34 | 4 | explicit E-S complex | Substrate
PP1-I1*
Product
PP1-I1
| | | Liu and Storm JBC 1989 264(22):12800-12804 say Km ~ 5 uM, Vmax = 256 nmol/min/mg ~ 0.34/sec |
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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