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Enzyme List for CamKII

Entries are grouped according to Pathway Number and they are alternately color coded using

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	Enzyme Molecule / Enzyme Activity	Accession Name / Accession No.	Pathway Name / Pathway No.	Km (uM)	kcat (s^-1)	Ratio (k2/k3)	Enzyme Type	Reagents
41	tot_CaM_CaMKII / CaM-CaMK-phos1	Osc_Ca_ IP3metabolism Accession No. 32	CaMKII Pathway No. 159	1.59998	0.5	4	explicit E-S complex	Substrate: IP3_3K_CaM Product : IP3_3K_CaM*
	rates referred from standard CaM-CaMKII phosphorylation rates
42	tot_autonomous_ CaMKII / auton_305	Osc_Ca_ IP3metabolism Accession No. 32	CaMKII Pathway No. 159	0.00000416667	6	4	explicit E-S complex	Substrate: CaMKII-thr286 Product : CaMKII***
	See Hanson and Schulman 1992 JBC 267(24):17216-17224 for afterburst rates of phosphorylation
43	tot_autonomous_ CaMKII / auton_286	Osc_Ca_ IP3metabolism Accession No. 32	CaMKII Pathway No. 159	0.00000416667	0.5	4	explicit E-S complex	Substrate: CaMKII-CaM Product : CaMKII-thr286*-C aM
	The autonomous rate has a slightly higher Km than the CaM-bound rate, but Vmax is the same. Hanson and Schulman 1992 Ann Rev Biochem 61:559-601 and Hanson and Schulman 1992 JBC 267(24):17216-17224
44	tot_autonomous_ CaMKII / CaMK-phos	Osc_Ca_ IP3metabolism Accession No. 32	CaMKII Pathway No. 159	2.49999	0.5	4	explicit E-S complex	Substrate: IP3_3K Product : IP3_3K*
	rates referred from standard CaMKII phosphorylation rates
45	tot_autonomous_ CaMKII / CaMK-phos1	Osc_Ca_ IP3metabolism Accession No. 32	CaMKII Pathway No. 159	2.49995	0.5	4	explicit E-S complex	Substrate: IP3_3K_CaM Product : IP3_3K_CaM*
	rates referred from standard CaMKII phosphorylation rates
46	Tot-active-CaMKI I / phosph_T286	CaMKII Accession No. 33	CaMKII Pathway No. 174	0.254651	10	0	explicit E-S complex	Substrate: CaMKII-CaMCa4 Product : Trapped-T286
	This enzyme represents an intra-holoenzyme reaction from one active subunit to its neighbor. k1 is now in units of 1/sec. The Km, Ratio and Vmax terms are pretty meaningless. The enzyme really is there just to represent the forward rate of 0.5 from CaMKII-CaMCa4 to Trapped-T285. We have a high k3 so that the reac is limited only by k1. The enzyme itself does not have much purpose other than to allow scaling of the overall rate by the proportion of adjacent molecules in the appropriate state.
47	Tot-active-CaMKI I / phosph_T305	CaMKII Accession No. 33	CaMKII Pathway No. 174	1.27325	10	0	explicit E-S complex	Substrate: Autonomous Product : Capped
	This enzyme also represents an intra-holoenzyme reaction. So it is not really treated as an enzyme in Holme's model, more like a probability of reaction that scales according to the number of active CaMKII neighboring subunits. Here we approximate it as an enzyme rate limited by the k1=0.1 step, no back reaction, and with a scaling from Total_CaMKII such that the effective forward rate will simply be the fraction of CaMKII that are active, times 1/10 for nearest neigbors, times k1.
48	tot_CaM_CaMKII / CaM_act_305	CaMKII_2003 Accession No. 49	CaMKII Pathway No. 202	113.6	6	4	explicit E-S complex	Substrate: CaMKII-thr286 Product : CaMKII***
	Rates from autocamtide phosphorylation, from Hanson and Schulman JBC 267:24 17216-17224 1992. Jan 1 1998: Speed up 12x to match fig 5.
49	tot_CaM_CaMKII / CaM_act_286	CaMKII_2003 Accession No. 49	CaMKII Pathway No. 202	113.601	0.5	4	explicit E-S complex	Substrate: CaMKII-CaM Product : CaMKII-thr286*-C aM
50	tot_autonomous_ CaMKII / auton_305	CaMKII_2003 Accession No. 49	CaMKII Pathway No. 202	175.003	6	4	explicit E-S complex	Substrate: CaMKII-thr286 Product : CaMKII***
	See Hanson and Schulman again, for afterburst rates of phosph.
51	tot_autonomous_ CaMKII / auton_286	CaMKII_2003 Accession No. 49	CaMKII Pathway No. 202	174.997	0.5	4	explicit E-S complex	Substrate: CaMKII-CaM Product : CaMKII-thr286*-C aM
52	tot_CaM_CaMKII / CaM_act_305	MAPK_network_ 2003 Accession No. 50	CaMKII Pathway No. 216	113.6	6	4	explicit E-S complex	Substrate: CaMKII-thr286 Product : CaMKII***
	Rates from autocamtide phosphorylation, from Hanson and Schulman JBC 267:24 17216-17224 1992. Jan 1 1998: Speed up 12x to match fig 5.
53	tot_CaM_CaMKII / CaM_act_286	MAPK_network_ 2003 Accession No. 50	CaMKII Pathway No. 216	113.601	0.5	4	explicit E-S complex	Substrate: CaMKII-CaM Product : CaMKII-thr286*-C aM
54	tot_autonomous_ CaMKII / auton_305	MAPK_network_ 2003 Accession No. 50	CaMKII Pathway No. 216	175.003	6	4	explicit E-S complex	Substrate: CaMKII-thr286 Product : CaMKII***
	See Hanson and Schulman again, for afterburst rates of phosph.
55	tot_autonomous_ CaMKII / auton_286	MAPK_network_ 2003 Accession No. 50	CaMKII Pathway No. 216	174.997	0.5	4	explicit E-S complex	Substrate: CaMKII-CaM Product : CaMKII-thr286*-C aM
56	tot_CaM_CaMKII / CaM_act_305	AMPAR_traff_ model0 Accession No. 59	CaMKII Pathway No. 235	113.601	6	4	explicit E-S complex	Substrate: CaMKII-thr286 Product : CaMKII***
	Rates from autocamtide phosphorylation, from Hanson and Schulman JBC 267:24 17216-17224 1992. Jan 1 1998: Speed up 12x to match fig 5.
57	tot_CaM_CaMKII / CaM_act_286	AMPAR_traff_ model0 Accession No. 59	CaMKII Pathway No. 235	113.602	0.5	4	explicit E-S complex	Substrate: CaMKII-CaM Product : CaMKII-thr286*-C aM
58	tot_autonomous_ CaMKII / auton_305	AMPAR_traff_ model0 Accession No. 59	CaMKII Pathway No. 235	175	6	4	explicit E-S complex	Substrate: CaMKII-thr286 Product : CaMKII***
	See Hanson and Schulman again, for afterburst rates of phosph.
59	tot_autonomous_ CaMKII / auton_286	AMPAR_traff_ model0 Accession No. 59	CaMKII Pathway No. 235	174.994	0.5	4	explicit E-S complex	Substrate: CaMKII-CaM Product : CaMKII-thr286*-C aM
60	actCaMKII-PSD / CaMKII	AMPAR_traff_ model0 Accession No. 59	CaMKII Pathway No. 235	90.0006	0.5	4	explicit E-S complex	Substrate: A845_B845 Product : A831845_B845*

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