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Enzyme List for CamKII

Entries are grouped according to Pathway Number and they are alternately color coded using

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	Enzyme Molecule / Enzyme Activity	Accession Name / Accession No.	Pathway Name / Pathway No.	Km (uM)	kcat (s^-1)	Ratio (k2/k3)	Enzyme Type	Reagents
1	act_CaMKII / ph_AMPAR	BCM Accession No. 96	bcm Pathway No. 1118	1.00369025	2	4	explicit E-S complex	Substrate: AMPAR Product : p_AMPAR
2	Tot-active-CaMKI I / phosph_T305	CaMKII Accession No. 33	CaMKII Pathway No. 174	1.27325	10	0	explicit E-S complex	Substrate: Autonomous Product : Capped
	This enzyme also represents an intra-holoenzyme reaction. So it is not really treated as an enzyme in Holme's model, more like a probability of reaction that scales according to the number of active CaMKII neighboring subunits. Here we approximate it as an enzyme rate limited by the k1=0.1 step, no back reaction, and with a scaling from Total_CaMKII such that the effective forward rate will simply be the fraction of CaMKII that are active, times 1/10 for nearest neigbors, times k1.
3	Tot-active-CaMKI I / phosph_T286	CaMKII Accession No. 33	CaMKII Pathway No. 174	0.254651	10	0	explicit E-S complex	Substrate: CaMKII-CaMCa4 Product : Trapped-T286
	This enzyme represents an intra-holoenzyme reaction from one active subunit to its neighbor. k1 is now in units of 1/sec. The Km, Ratio and Vmax terms are pretty meaningless. The enzyme really is there just to represent the forward rate of 0.5 from CaMKII-CaMCa4 to Trapped-T285. We have a high k3 so that the reac is limited only by k1. The enzyme itself does not have much purpose other than to allow scaling of the overall rate by the proportion of adjacent molecules in the appropriate state.
4	CaMKIII_CaM-Ca4 / phospho	CaMKIII Accession No. 90	Shared_Object_ CaMKIII Pathway No. 1093	1.99998	10	4	explicit E-S complex	Substrate: eEF2 Product : eEFthr-56
5	CaMKIIalpha / kenz	NOS_Phosph_ regulation Accession No. 20	NOS Pathway No. 90	5	28.5	4	explicit E-S complex	Substrate: nNOS Product : NOS*
	Hayashi et al., 1999, JBC,274(29):20597-20602. and from various other literature datas.
6	CaMKIII_basal / eEF2thr56_basal	CaMKIII Accession No. 90	Shared_Object_ CaMKIII Pathway No. 1093	1.99998	10	4	explicit E-S complex	Substrate: eEF2 Product : eEFthr-56
7	PP1-active_ CaMKII_PSD / Deph-thr305a	AMPAR_CaMKII_ weak_coupling Accession No. 65	PP1_CaMKII_PSD Pathway No. 291	2.00001	0.2	4	explicit E-S complex	Substrate: CaMKII-thr305-PS D Product : CaMKII-PSD
8	PP1-active_ CaMKII_PSD / Deph-thr305	AMPAR_CaMKII_ weak_coupling Accession No. 65	PP1_CaMKII_PSD Pathway No. 291	2.00001	0.2	4	explicit E-S complex	Substrate: CaMKII*-PSD Product :** CaMKII-thr286-PS D
9	PP1-active_ CaMKII_PSD / Deph-thr286c	AMPAR_CaMKII_ weak_coupling Accession No. 65	PP1_CaMKII_PSD Pathway No. 291	2.00001	0.2	4	explicit E-S complex	Substrate: CaMKII*-PSD Product :** CaMKII-thr305-PS D
10	PP1-active_ CaMKII_PSD / Deph-thr286b	AMPAR_CaMKII_ weak_coupling Accession No. 65	PP1_CaMKII_PSD Pathway No. 291	2.00001	0.2	4	explicit E-S complex	Substrate: CaMKII-thr286-PS D Product : CaMKII-PSD
11	PP1-active_ CaMKII_PSD / Deph-thr286	AMPAR_CaMKII_ weak_coupling Accession No. 65	PP1_CaMKII_PSD Pathway No. 291	2.00001	0.2	4	explicit E-S complex	Substrate: CaMKII-thr286-Ca M-PSD Product : CaMKII-CaM-PSD
12	tot-CaM-CaMKII-P SD / CaM_act_autoph	CaMKII_noPKA_ model3 Accession No. 62	Shared_Object_ CaMKII_noPKA_ model3 Pathway No. 257	320.002	2	4	explicit E-S complex	Substrate: CaMKII-PSD Product : CaMKII-thr286-PS D
13	tot-CaM-CaMKII-P SD / CaM_act_autoph	CaMKII_model3 Accession No. 63	Shared_Object_ CaMKII_model3 Pathway No. 263	320.002	2	4	explicit E-S complex	Substrate: CaMKII-PSD Product : CaMKII-thr286-PS D
14	tot-CaM-CaMKII-P SD / CaM_act_autoph	AMPAR_CaMKII_ strong_coupling Accession No. 64	Shared_Object_ AMPAR_CaMKII_ strong_coupling Pathway No. 271	320.002	2	4	explicit E-S complex	Substrate: CaMKII-PSD Product : CaMKII-thr286-PS D
15	tot-CaM-CaMKII-P SD / CaM_act_autoph	AMPAR_CaMKII_ weak_coupling Accession No. 65	CaMKII_PSD Pathway No. 292	320.002	2	4	explicit E-S complex	Substrate: CaMKII-PSD Product : CaMKII-thr286-PS D
16	tot_CaM_CaMKII / CaM_act_305	fig3_CaMKII Accession No. 2	CaMKII Pathway No. 13	0.00000270563	6	4	explicit E-S complex	Substrate: CaMKII-thr286 Product : CaMKII***
17	tot_CaM_CaMKII / CaM_act_305	fig4_synapse Accession No. 3	CaMKII Pathway No. 26	0.00000270563	6	4	explicit E-S complex	Substrate: CaMKII-thr286 Product : CaMKII***
18	tot_CaM_CaMKII / CaM_act_305	Synaptic_ Network Accession No. 16	CaMKII Pathway No. 80	0.00000270563	6	4	explicit E-S complex	Substrate: CaMKII-thr286 Product : CaMKII***
	Rates from autocamtide phosphorylation, from Hanson and Schulman JBC 267:24 17216-17224 1992. See especially Fig 5.
19	tot_CaM_CaMKII / CaM_act_305	NonOsc_Ca_ IP3metabolism Accession No. 23	CaMKII Pathway No. 106	0.00000270563	6	4	explicit E-S complex	Substrate: CaMKII-thr286 Product : CaMKII***
	Rates from autocamtide phosphorylation, from Hanson and Schulman JBC 267:24 17216-17224 1992. See especially Fig 5.
20	tot_CaM_CaMKII / CaM_act_305	Osc_Ca_ IP3metabolism Accession No. 24	CaMKII Pathway No. 121	0.00000270563	6	4	explicit E-S complex	Substrate: CaMKII-thr286 Product : CaMKII***
	Rates from autocamtide phosphorylation, from Hanson and Schulman JBC 267:24 17216-17224 1992. See especially Fig 5.

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