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Enzyme List for CamKII

Entries are grouped according to Pathway Number and they are alternately color coded using

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	Enzyme Molecule / Enzyme Activity	Accession Name / Accession No.	Pathway Name / Pathway No.	Km (uM)	kcat (s^-1)	Ratio (k2/k3)	Enzyme Type	Reagents
1	CaMKIIalpha / kenz	NOS_Phosph_ regulation Accession No. 20	NOS Pathway No. 90	5	28.5	4	explicit E-S complex	Substrate: nNOS Product : NOS*
	Hayashi et al., 1999, JBC,274(29):20597-20602. and from various other literature datas.
2	Tot-active-CaMKI I / phosph_T286	CaMKII Accession No. 33	CaMKII Pathway No. 174	0.254651	10	0	explicit E-S complex	Substrate: CaMKII-CaMCa4 Product : Trapped-T286
	This enzyme represents an intra-holoenzyme reaction from one active subunit to its neighbor. k1 is now in units of 1/sec. The Km, Ratio and Vmax terms are pretty meaningless. The enzyme really is there just to represent the forward rate of 0.5 from CaMKII-CaMCa4 to Trapped-T285. We have a high k3 so that the reac is limited only by k1. The enzyme itself does not have much purpose other than to allow scaling of the overall rate by the proportion of adjacent molecules in the appropriate state.
3	Tot-active-CaMKI I / phosph_T305	CaMKII Accession No. 33	CaMKII Pathway No. 174	1.27325	10	0	explicit E-S complex	Substrate: Autonomous Product : Capped
	This enzyme also represents an intra-holoenzyme reaction. So it is not really treated as an enzyme in Holme's model, more like a probability of reaction that scales according to the number of active CaMKII neighboring subunits. Here we approximate it as an enzyme rate limited by the k1=0.1 step, no back reaction, and with a scaling from Total_CaMKII such that the effective forward rate will simply be the fraction of CaMKII that are active, times 1/10 for nearest neigbors, times k1.
4	CaMKIII_CaM-Ca4 / phospho	CaMKIII Accession No. 90	Shared_Object_ CaMKIII Pathway No. 1093	1.99998	10	4	explicit E-S complex	Substrate: eEF2 Product : eEFthr-56
5	CaMKIII_basal / eEF2thr56_basal	CaMKIII Accession No. 90	Shared_Object_ CaMKIII Pathway No. 1093	1.99998	10	4	explicit E-S complex	Substrate: eEF2 Product : eEFthr-56
6	S6K_basal / CaMKIII_basal	CaMKIII Accession No. 90	Shared_Object_ CaMKIII Pathway No. 1093	0.999896	10	4	explicit E-S complex	Substrate: CaMKIII Product : CaMKIII*
7	tot_CaM_CaMKII / CaM_act_305	fig3_CaMKII Accession No. 2	CaMKII Pathway No. 13	0.00000270563	6	4	explicit E-S complex	Substrate: CaMKII-thr286 Product : CaMKII***
8	tot_autonomous_ CaMKII / auton_305	fig3_CaMKII Accession No. 2	CaMKII Pathway No. 13	0.00000416667	6	4	explicit E-S complex	Substrate: CaMKII-thr286 Product : CaMKII***
9	tot_CaM_CaMKII / CaM_act_305	fig4_synapse Accession No. 3	CaMKII Pathway No. 26	0.00000270563	6	4	explicit E-S complex	Substrate: CaMKII-thr286 Product : CaMKII***
10	tot_autonomous_ CaMKII / auton_305	fig4_synapse Accession No. 3	CaMKII Pathway No. 26	0.00000416667	6	4	explicit E-S complex	Substrate: CaMKII-thr286 Product : CaMKII***
11	tot_CaM_CaMKII / CaM_act_305	Synaptic_ Network Accession No. 16	CaMKII Pathway No. 80	0.00000270563	6	4	explicit E-S complex	Substrate: CaMKII-thr286 Product : CaMKII***
	Rates from autocamtide phosphorylation, from Hanson and Schulman JBC 267:24 17216-17224 1992. See especially Fig 5.
12	tot_autonomous_ CaMKII / auton_305	Synaptic_ Network Accession No. 16	CaMKII Pathway No. 80	0.00000416667	6	4	explicit E-S complex	Substrate: CaMKII-thr286 Product : CaMKII***
	See Hanson and Schulman 1992 JBC 267(24):17216-17224 for afterburst rates of phosphorylation
13	tot_CaM_CaMKII / CaM_act_305	NonOsc_Ca_ IP3metabolism Accession No. 23	CaMKII Pathway No. 106	0.00000270563	6	4	explicit E-S complex	Substrate: CaMKII-thr286 Product : CaMKII***
	Rates from autocamtide phosphorylation, from Hanson and Schulman JBC 267:24 17216-17224 1992. See especially Fig 5.
14	tot_autonomous_ CaMKII / auton_305	NonOsc_Ca_ IP3metabolism Accession No. 23	CaMKII Pathway No. 106	0.00000416667	6	4	explicit E-S complex	Substrate: CaMKII-thr286 Product : CaMKII***
	See Hanson and Schulman 1992 JBC 267(24):17216-17224 for afterburst rates of phosphorylation
15	tot_CaM_CaMKII / CaM_act_305	Osc_Ca_ IP3metabolism Accession No. 24	CaMKII Pathway No. 121	0.00000270563	6	4	explicit E-S complex	Substrate: CaMKII-thr286 Product : CaMKII***
	Rates from autocamtide phosphorylation, from Hanson and Schulman JBC 267:24 17216-17224 1992. See especially Fig 5.
16	tot_autonomous_ CaMKII / auton_305	Osc_Ca_ IP3metabolism Accession No. 24	CaMKII Pathway No. 121	0.00000416667	6	4	explicit E-S complex	Substrate: CaMKII-thr286 Product : CaMKII***
	See Hanson and Schulman 1992 JBC 267(24):17216-17224 for afterburst rates of phosphorylation
17	tot_CaM_CaMKII / CaM_act_305	NonOsc_Ca_ IP3metabolism Accession No. 31	CaMKII Pathway No. 145	0.00000270563	6	4	explicit E-S complex	Substrate: CaMKII-thr286 Product : CaMKII***
	Rates from autocamtide phosphorylation, from Hanson and Schulman JBC 267:24 17216-17224 1992. See especially Fig 5.
18	tot_autonomous_ CaMKII / auton_305	NonOsc_Ca_ IP3metabolism Accession No. 31	CaMKII Pathway No. 145	0.00000416667	6	4	explicit E-S complex	Substrate: CaMKII-thr286 Product : CaMKII***
	See Hanson and Schulman 1992 JBC 267(24):17216-17224 for afterburst rates of phosphorylation
19	tot_CaM_CaMKII / CaM_act_305	Osc_Ca_ IP3metabolism Accession No. 32	CaMKII Pathway No. 159	0.00000270563	6	4	explicit E-S complex	Substrate: CaMKII-thr286 Product : CaMKII***
	Rates from autocamtide phosphorylation, from Hanson and Schulman JBC 267:24 17216-17224 1992. See especially Fig 5.
20	tot_autonomous_ CaMKII / auton_305	Osc_Ca_ IP3metabolism Accession No. 32	CaMKII Pathway No. 159	0.00000416667	6	4	explicit E-S complex	Substrate: CaMKII-thr286 Product : CaMKII***
	See Hanson and Schulman 1992 JBC 267(24):17216-17224 for afterburst rates of phosphorylation

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