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Molecule Parameter List for Ca | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by  color. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Statistics | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Ca participated as | Molecule | Sum total of | Enzyme | Substrate of an enzyme | Product of an enzyme | Substrate in Reaction | Product in Reaction |
| No. of occurrences | 1 | 0 | 0 | 1 | 0 | 8 | 0 |
Accession and Pathway Details |
| Accession Name | Accession No. | Accession Type | Pathway Link |
| fig2_egfr | 1 | Network | Shared_Object_fig2_egfr, PKC, PLA2, PLCbeta, Gq, MAPK, Ras, EGFR, Sos, PLC_g, CaRegulation |
| This network was used to generate figure 2 in Bhalla US and Iyengar R. Science (1999) 283(5400):381-7. It consists of the MAPK cascade in a feedback loop with PKC, and receives input from the EGFR in the synapse. Demonstration script files for generating the figures in the paper, including figure 2, are available here. | |||
Ca acting as a Molecule in fig2_egfr Network
| Name | Accession Name | Pathway Name | Initial Conc. (uM) | Volume (fL) | Buffered | |
| Ca | fig2_egfr Accession No. : 1 | fig2_egfr Pathway No. : 1 | 0.08 | 1000 | No | |
Ca acting as a Substrate for an Enzyme in fig2_egfr Network
| Enzyme Molecule / Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents |
| CaEPump / Ca-pump-out | fig2_egfr Accession No. : 1 | CaRegulation Pathway No. : 11 | 0.2 | 72 | 4 | explicit E-S complex | Substrate Ca Product Ca-ext |
Ca acting as a Substrate in a reaction in fig2_egfr Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | |
| 1 | PKC-act-by-Ca | fig2_egfr Accession No. : 1 | PKC Pathway No. : 2 | 0.6 (uM^-1 s^-1) | 0.5 (s^-1) | Kd(bf) = 0.8333(uM) | - | Substrate Ca PKC-cytosolic Product PKC-Ca |
| 2 | PLA2-Ca-act | fig2_egfr Accession No. : 1 | PLA2 Pathway No. : 3 | 1 (uM^-1 s^-1) | 0.1 (s^-1) | Kd(bf) = 0.1(uM) | - | Substrate Ca PLA2-cytosolic Product PLA2-Ca* |
| 3 | PLA2*-Ca-act | fig2_egfr Accession No. : 1 | PLA2 Pathway No. : 3 | 6 (uM^-1 s^-1) | 0.1 (s^-1) | Kd(bf) = 0.0167(uM) | - | Substrate Ca PLA2* Product PLA2*-Ca |
| 4 | Act-PLC-Ca | fig2_egfr Accession No. : 1 | PLCbeta Pathway No. : 4 | 3 (uM^-1 s^-1) | 1 (s^-1) | Kd(bf) = 0.3333(uM) | - | Substrate Ca PLC Product PLC-Ca |
| 5 | PLC-Gq-bind-Ca | fig2_egfr Accession No. : 1 | PLCbeta Pathway No. : 4 | 30 (uM^-1 s^-1) | 1 (s^-1) | Kd(bf) = 0.0333(uM) | - | Substrate Ca PLC-Gq Product PLC-Ca-Gq |
| 6 | Ca_act_PLC_g | fig2_egfr Accession No. : 1 | PLC_g Pathway No. : 10 | 180 (uM^-1 s^-1) | 10 (s^-1) | Kd(bf) = 0.0556(uM) | - | Substrate Ca PLC_g Product Ca.PLC_g |
| 7 | Ca_act_PLC_g* | fig2_egfr Accession No. : 1 | PLC_g Pathway No. : 10 | 12 (uM^-1 s^-1) | 10 (s^-1) | Kd(bf) = 0.8333(uM) | - | Substrate Ca PLC_G* Product Ca.PLC_g* |
| 8 | p | fig2_egfr Accession No. : 1 | CaRegulation Pathway No. : 11 | 3600 (uM^-2 s^-1) | 144 (s^-1) | Kd(af) = 0.2(uM) | - | Substrate Ca Ca CaTransp Product CaTransp-2Ca |