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Molecule Parameter List for Ca

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by

color.

Statistics

Ca participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	0	0	1	0	8	0

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
fig2_egfr	1	Network	Shared_Object_fig2_egfr, PKC, PLA2, PLCbeta, Gq, MAPK, Ras, EGFR, Sos, PLC_g, CaRegulation
This network was used to generate figure 2 in Bhalla US and Iyengar R. Science (1999) 283(5400):381-7. It consists of the MAPK cascade in a feedback loop with PKC, and receives input from the EGFR in the synapse. Demonstration script files for generating the figures in the paper, including figure 2, are available here.

Ca acting as a Molecule in fig2_egfr Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
Ca	fig2_egfr Accession No. : 1	Shared_Object_ fig2_egfr Pathway No. : 1	0.08	1000	No

Ca acting as a Substrate for an Enzyme in fig2_egfr Network

Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
CaEPump / Ca-pump-out	fig2_egfr Accession No. : 1	CaRegulation Pathway No. : 11	0.2	72	4	explicit E-S complex	Substrate Ca Product Ca-ext

Ca acting as a Substrate in a reaction in fig2_egfr Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

	Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
1	PKC-act-by-Ca	fig2_egfr Accession No. : 1	PKC Pathway No. : 2	0.6 (uM^-1 s^-1)	0.5 (s^-1)	Kd(bf) = 0.8333(uM)	-	Substrate Ca PKC-cytosolic Product PKC-Ca
2	PLA2-Ca-act	fig2_egfr Accession No. : 1	PLA2 Pathway No. : 3	1 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 0.1(uM)	-	Substrate Ca PLA2-cytosolic Product PLA2-Ca*
3	PLA2*-Ca-act	fig2_egfr Accession No. : 1	PLA2 Pathway No. : 3	6 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 0.0167(uM)	-	Substrate Ca PLA2* Product PLA2*-Ca
4	Act-PLC-Ca	fig2_egfr Accession No. : 1	PLCbeta Pathway No. : 4	3 (uM^-1 s^-1)	1 (s^-1)	Kd(bf) = 0.3333(uM)	-	Substrate Ca PLC Product PLC-Ca
5	PLC-Gq-bind-Ca	fig2_egfr Accession No. : 1	PLCbeta Pathway No. : 4	30 (uM^-1 s^-1)	1 (s^-1)	Kd(bf) = 0.0333(uM)	-	Substrate Ca PLC-Gq Product PLC-Ca-Gq
6	Ca_act_PLC_g	fig2_egfr Accession No. : 1	PLC_g Pathway No. : 10	180 (uM^-1 s^-1)	10 (s^-1)	Kd(bf) = 0.0556(uM)	-	Substrate Ca PLC_g Product Ca.PLC_g
7	Ca_act_PLC_g*	fig2_egfr Accession No. : 1	PLC_g Pathway No. : 10	12 (uM^-1 s^-1)	10 (s^-1)	Kd(bf) = 0.8333(uM)	-	Substrate Ca PLC_G* Product Ca.PLC_g*
8	Ca-bind-to-Trans p	fig2_egfr Accession No. : 1	CaRegulation Pathway No. : 11	3600 (uM^-2 s^-1)	144 (s^-1)	Kd(af) = 0.2(uM)	-	Substrate Ca Ca CaTransp Product CaTransp-2Ca

Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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