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Molecule Parameter List for IP3

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by color.

Statistics

IP3 participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	0	0	0	4	2	0

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
fig2_egfr	1	Network	Shared_Object_fig2_egfr,  PKC,  PLA2,   PLCbeta,  Gq,  MAPK,   Ras,  EGFR,  Sos,   PLC_g,  CaRegulation
This network was used to generate figure 2 in Bhalla US and Iyengar R. Science (1999) 283(5400):381-7. It consists of the MAPK cascade in a feedback loop with PKC, and receives input from the EGFR in the synapse. Demonstration script files for generating the figures in the paper, including figure 2, are available here.

IP3 acting as a Molecule in  fig2_egfr Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
IP3	fig2_egfr Accession No. : 1	Shared_Object_ fig2_egfr Pathway No. : 1	0	1000	No

IP3 acting as a Product of an Enzyme in  fig2_egfr Network

	Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
1	PLC-Ca  / PLC-Ca	fig2_egfr Accession No. : 1	PLCbeta Pathway No. : 4	19.8413	10	4	explicit E-S complex	Substrate PIP2 Product DAG IP3
2	PLC-Ca-Gq  / PLCb-Ca-Gq	fig2_egfr Accession No. : 1	PLCbeta Pathway No. : 4	5	48	4	explicit E-S complex	Substrate PIP2 Product DAG IP3
3	Ca.PLC_g  / PIP2_hydrolysis	fig2_egfr Accession No. : 1	PLC_g Pathway No. : 10	97.2222	14	4	Classical Michaelis-Menten V = Etot.S.Kcat/Km+S	Substrate PIP2 Product DAG IP3
4	Ca.PLC_g*  / PIP2_hydrolysis	fig2_egfr Accession No. : 1	PLC_g Pathway No. : 10	19.7917	57	4	Classical Michaelis-Menten V = Etot.S.Kcat/Km+S	Substrate PIP2 Product DAG IP3

IP3 acting as a Substrate in a reaction in  fig2_egfr Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

	Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
1	Degrade-IP3	fig2_egfr Accession No. : 1	PLCbeta Pathway No. : 4	2.5 (s^-1)	0 (s^-1)	-	-	Substrate IP3 Product Inositol
2	IP3Rbind	fig2_egfr Accession No. : 1	CaRegulation Pathway No. : 11	0.0022 (uM^-3 s^-1)	1 (s^-1)	Kd(af) = 7.736(uM)	-	Substrate IP3 IP3 IP3 IP3R Product IP3R*