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Molecule Parameter List for CaM(Ca)n-CaNAB

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by color.

Statistics

CaM(Ca)n-CaNAB participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	1	3	0	0	0	0

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
Synaptic_ Network	16	Network	Shared_Object_Synaptic_Network,  PKC,  PLA2,   PLCbeta,  Gq,  MAPK,   Ras,  EGFR,  Sos,   PLC_g,  CaMKII,  CaM,   PP1,  PP2B,  PKA,   AC,  CaRegulation
This model is an annotated version of the synaptic signaling network. The primary reference is Bhalla US and Iyengar R. Science (1999) 283(5400):381-7 but several of the model pathways have been updated. Bhalla US Biophys J. 2002 Aug;83(2):740-52 Bhalla US J Comput Neurosci. 2002 Jul-Aug;13(1):49-62

CaM(Ca)n-CaNAB acting as a Molecule in  Synaptic_Network Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
CaM(Ca)n-CaNAB	Synaptic_ Network Accession No. : 16	Shared_Object_ Synaptic_ Network Pathway No. : 70	0	1000	No
This pool sums the levels of the CaM.Ca2.CaNAB, CaM.Ca3.CaNAB and CaM.Ca4.CaNAB pools.

CaM(Ca)n-CaNAB acting as a Summed Molecule in  Synaptic_Network Network

Accession Name	Pathway Name	Target	Input
Synaptic_ Network Accession No. : 16	Shared_Object_ Synaptic_ Network Pathway No. : 70	CaM(Ca)n-CaNAB	CaMCa4-CaNAB CaMCa3-CaNAB CaMCa2-CANAB
This pool sums the levels of the CaM.Ca2.CaNAB, CaM.Ca3.CaNAB and CaM.Ca4.CaNAB pools.

CaM(Ca)n-CaNAB acting as an Enzyme in  Synaptic_Network Network

	Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
1	CaM(Ca)n-CaNAB / dephosph_ neurogranin	Synaptic_ Network Accession No. : 16	Shared_Object_ Synaptic_ Network Pathway No. : 70	10.012	0.67	3.98507	explicit E-S complex	Substrate neurogranin* Product neurogranin
	From Seki et al ABB 316(2):673-679
2	CaM(Ca)n-CaNAB / dephosph_inhib1	Synaptic_ Network Accession No. : 16	Shared_Object_ Synaptic_ Network Pathway No. : 70	4.97076	0.34	4	explicit E-S complex	Substrate I1* Product I1
	Assume the rates are the same when dephosphorylating I1 either when it is floating freely, or when it is bound to PP1 catalytic subunit. This is from Liu and Storm 1989 264(22):12800-12804
3	CaM(Ca)n-CaNAB / dephosph-PP1-I*	Synaptic_ Network Accession No. : 16	Shared_Object_ Synaptic_ Network Pathway No. : 70	4.97076	0.34	4	explicit E-S complex	Substrate PP1-I1* Product PP1-I1
	Liu and Storm JBC 1989 264(22):12800-12804 say Km ~ 5 uM, Vmax = 256 nmol/min/mg ~ 0.34/sec