| |
Reaction
Name | Pathway Name /
Pathway No. | Kf | Kb | Kd | tau | Reagents |
| 1 | CaN-bind-CaM | CaN
Pathway No. 175 | 0.2
(uM^-1 s^-1) | 5000
(s^-1) | Kd(bf) = 25000(uM) | - | Substrate:
CaM
CaN
Products:
CaN-CaM
|
| 2 | CaN-bind-CaMCa | CaN
Pathway No. 175 | 5
(uM^-1 s^-1) | 3750
(s^-1) | Kd(bf) = 749.9955(uM) | - | Substrate:
CaMCa
CaN
Products:
CaN-CaMCa
|
| 3 | CaN-CaM-bind-Ca | CaN
Pathway No. 175 | 100.004
(uM^-1 s^-1) | 60
(s^-1) | Kd(bf) = 0.6(uM) | - | Substrate:
CaN-CaM
Ca
Products:
CaN-CaMCa
|
| 4 | CaN-bind-CaMCa2 | CaN
Pathway No. 175 | 10.0004
(uM^-1 s^-1) | 1250
(s^-1) | Kd(bf) = 124.995(uM) | - | Substrate:
CaMCa2
CaN
Products:
CaN-CaMCa2
|
| 5 | CaN-CaMCa-bind-C
a | CaN
Pathway No. 175 | 100.004
(uM^-1 s^-1) | 10
(s^-1) | Kd(bf) = 0.1(uM) | - | Substrate:
CaN-CaMCa
Ca
Products:
CaN-CaMCa2
|
| 6 | CaN-CaMCa2-bind-
Ca | CaN
Pathway No. 175 | 100.004
(uM^-1 s^-1) | 8
(s^-1) | Kd(bf) = 0.08(uM) | - | Substrate:
CaN-CaMCa2
Ca
Products:
CaN-CaMCa3
|
| 7 | CaN-bind-CaMCa3 | CaN
Pathway No. 175 | 100.004
(uM^-1 s^-1) | 10
(s^-1) | Kd(bf) = 0.1(uM) | - | Substrate:
CaMCa3
CaN
Products:
CaN-CaMCa3
|
| 8 | CaN-bind-CaMCa4 | CaN
Pathway No. 175 | 100.004
(uM^-1 s^-1) | 0.6
(s^-1) | Kd(bf) = 0.006(uM) | - | Substrate:
CaMCa4
CaN
Products:
CaN-CaMCa4
|
| 9 | CaN-CaMCa3-bind-
Ca | CaN
Pathway No. 175 | 100.004
(uM^-1 s^-1) | 30
(s^-1) | Kd(bf) = 0.3(uM) | - | Substrate:
CaN-CaMCa3
Ca
Products:
CaN-CaMCa4
|
| 10 | CaMKII-CaMCa-bin
d-Ca | CaMKII
Pathway No. 174 | 100.004
(uM^-1 s^-1) | 20
(s^-1) | Kd(bf) = 0.2(uM) | - | Substrate:
CAMKII-CaMCa
Ca
Products:
CaMKII-CaMCa2
|
| 11 | CaMKII-bind-CaM | CaMKII
Pathway No. 174 | 0.2
(uM^-1 s^-1) | 2700
(s^-1) | Kd(bf) = 13500(uM) | - | Substrate:
CaM
CaMKII
Products:
CaMKII-CaM
|
| 12 | CaMKII-bind-CaMC
a | CaMKII
Pathway No. 174 | 0.8
(uM^-1 s^-1) | 2700
(s^-1) | Kd(bf) = 3375.0084(uM) | - | Substrate:
CaMCa
CaMKII
Products:
CAMKII-CaMCa
|
| 13 | CaMKII-bind-CaMC
a2 | CaMKII
Pathway No. 174 | 2
(uM^-1 s^-1) | 2250
(s^-1) | Kd(bf) = 1125(uM) | - | Substrate:
CaMCa2
CaMKII
Products:
CaMKII-CaMCa2
|
| 14 | CaMKII-bind-CaMC
a3 | CaMKII
Pathway No. 174 | 100.004
(uM^-1 s^-1) | 22.5
(s^-1) | Kd(bf) = 0.225(uM) | - | Substrate:
CaMCa3
CaMKII
Products:
CaMKII-CaMCa3
|
| 15 | CaMKII-CaMCa2-bi
nd-Ca | CaMKII
Pathway No. 174 | 100.004
(uM^-1 s^-1) | 2
(s^-1) | Kd(bf) = 0.02(uM) | - | Substrate:
CaMKII-CaMCa2
Ca
Products:
CaMKII-CaMCa3
|
| 16 | CaMKII-CaMCa3-bi
nd-Ca | CaMKII
Pathway No. 174 | 100.004
(uM^-1 s^-1) | 100
(s^-1) | Kd(bf) = 1(uM) | - | Substrate:
CaMKII-CaMCa3
Ca
Products:
CaMKII-CaMCa4
|
| 17 | CaMKII-bind-CaMC
a4 | CaMKII
Pathway No. 174 | 100.004
(uM^-1 s^-1) | 4.5
(s^-1) | Kd(bf) = 0.045(uM) | - | Substrate:
CaMCa4
CaMKII
Products:
CaMKII-CaMCa4
|
| 18 | CaMKII-CaM-bind-
Ca | CaMKII
Pathway No. 174 | 4
(uM^-1 s^-1) | 20
(s^-1) | Kd(bf) = 5(uM) | - | Substrate:
CaMKII-CaM
Ca
Products:
CAMKII-CaMCa
|
| 19 | Dephosph_
trapped_T286 | CaMKII
Pathway No. 174 | 0.003
(s^-1) | 0
(s^-1) | - | - | Substrate:
Trapped-T286
Products:
CaMKII-CaMCa4
|
| This rate is for the back reaction for the step represented here as a separate enzyme, but by Holmes as a single reversible reaction. Here it is treated as separate because the forward reaction is dependent on activity levels of the CaMKII, whereas the back reaction is not. Holmes tries a range of values for this back-reaction and says that it doesn't matter much. | | 20 | dephosph_T286 | CaMKII
Pathway No. 174 | 0.003
(s^-1) | 0
(s^-1) | - | - | Substrate:
Autonomous
Products:
CaMKII
|
and 
color.
