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Molecule Parameter List for CaM-Ca4-PSD

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by

color.

Statistics

*CaM-Ca4-PSD* participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	0	0	0	0	3	2

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
AMPAR_CaMKII_ weak_coupling	65	Network	Shared_Object_AMPAR_CaMKII_weak_coupling, CaMKII, CaM, PP1, PP2B, PP1_PSD, AMPAR, PKA, AC, AMPAR_memb, PP1_CaMKII_PSD, CaMKII_PSD
This is a model of weak coupling between the AMPAR traffikcing bistability, and the CaMKII autophosphorylation bistability. In this model, there are three stable states: Both off, AMPAR on, or both on. The fourth possible state: CaMKII on but AMPAR off, is not truly stable, since over the course of hours the AMPAR also turns on.

CaM-Ca4-PSD acting as a Molecule in AMPAR_CaMKII_weak_coupling Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
CaM-Ca4-PSD	AMPAR_CaMKII_ weak_coupling Accession No. : 65	Shared_Object_ AMPAR_CaMKII_ weak_coupling Pathway No. : 281	0	0.01	No

CaM-Ca4-PSD acting as a Substrate in a reaction in AMPAR_CaMKII_weak_coupling Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

	Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
1	equilib	AMPAR_CaMKII_ weak_coupling Accession No. : 65	Shared_Object_ AMPAR_CaMKII_ weak_coupling Pathway No. : 281	540 (s^-1)	60 (s^-1)	Not applicable**	-	Substrate CaM-Ca4-PSD Product CaM-Ca4
	Diffusional equilibrium between PSD- and cytosolic compartment. According to D. Bary in Cell Movements 2nd ed 2001 D for proteins is 5e-7 cm^2/s giving 10 ms for a translocation of 1 um.
2	CaMKII-bind-CaM- PSD	AMPAR_CaMKII_ weak_coupling Accession No. : 65	CaMKII_PSD Pathway No. : 292	49.9998 (uM^-1 s^-1)	0 (s^-1)	-	-	Substrate CaM-Ca4-PSD CaMKII-PSD Product CaMKII-CaM-PSD
3	CaMKII-thr286-bi nd-CaM-PSD	AMPAR_CaMKII_ weak_coupling Accession No. : 65	CaMKII_PSD Pathway No. : 292	1000.02 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 0.0001(uM)	-	Substrate CaM-Ca4-PSD CaMKII-thr286-PS D Product CaMKII-thr286-Ca M-PSD
	Same values as for the main compartment Can the main compartment pool of Ca/CaM be used?

CaM-Ca4-PSD acting as a Product in a reaction in AMPAR_CaMKII_weak_coupling Network

	Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
1	CaM-Ca3-bind-Ca- PSD	AMPAR_CaMKII_ weak_coupling Accession No. : 65	CaM Pathway No. : 283	0.465 (uM^-1 s^-1)	10 (s^-1)	Kd(bf) = 21.5048(uM)	-	Substrate Ca-PSD CaM-Ca3-PSD Product CaM-Ca4-PSD
	Use K3 = 21.5 uM here from Stemmer and Klee table 3. kb/kf =21.5 6e5 so kf = 7.75e-7, kb = 10*
2	CaMKII-diss-CaM	AMPAR_CaMKII_ weak_coupling Accession No. : 65	CaMKII_PSD Pathway No. : 292	5 (s^-1)	0 (uM^-1 s^-1)	-	-	Substrate CaMKII-CaM-PSD Product CaM-Ca4-PSD CaMKII-PSD

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