DOQCS Database

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	Molecule Name/ Site Name	Km (uM)	kcat (1/s)	Ratio (k2/k3)	Enzyme Type	Substrate	Product
1	Enzyme Activity: kenz Enzyme Molecule: PLA2-Ca*	20	5.4	4	explicit E-S complex	APC	AA
	Based on Leslie and Channon 1990 BBA 1045:261, in relation to the other PLA2 inputs (not including MAPK). Ca alone is rather a weak input.
2	Enzyme Activity: kenz Enzyme Molecule: PIP2-PLA2*	20	11.04	4	explicit E-S complex	APC	AA
	Based on Leslie and Channon 1990 BBA 1045:261.
3	Enzyme Activity: kenz Enzyme Molecule: PIP2-Ca-PLA2*	20	36	4	explicit E-S complex	APC	AA
	Based on AA generation by different stimuli according to Leslie and Channon 1990 BBA 1045:261
4	Enzyme Activity: kenz Enzyme Molecule: DAG-Ca-PLA2*	20	60	4	explicit E-S complex	APC	AA
	Based on Leslie and Channon 1990 BBA 1045:261.
5	Enzyme Activity: kenz Enzyme Molecule: PLA2*-Ca	20	120	4	explicit E-S complex	APC	AA
	This form should be 3 to 6 times as fast as the Ca-only form, from Lin et al 1993 Cell 269-278 Nemenoff et al 1993 JBC 268:1960 Several forms contribute to the Ca-stimulated form, so this rate has to be a factor larger than their total contribution. I assign Vmax as the scale factor here because there is lots of APC substrate, so all the PLA2 complex enzymes are limited primarily by Vmax.

Enzyme List