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Enzyme List for pathway PLC_g (Pathway Number 79)

 Molecule Name/
Site Name 		Km (uM) kcat (1/s)Ratio
(k2/k3)		Enzyme TypeSubstrate Product
1 Enzyme Activity:
PIP2_hydrolysis

Enzyme Molecule:
Ca.PLC_g		97.2222144Classical Michaelis-Menten
V = Etot.S.Kcat/Km+S		PIP2
DAG
IP3
  Wahl et al JBC 267(15) 10447-10456 1992. Homma et al JBC 263:14 1988 pp 6592. These parms are the Ca-stimulated form. This is close to Wahl's figure 7, which I am using as reference. Also see Nakanishi et al Biochem J 256 453-459 1998, Nishibe et al Science 250 :1253-1256 This model uses a rather low PIP2 of 10 uM.
2 Enzyme Activity:
PIP2_hydrolysis

Enzyme Molecule:
Ca.PLC_g*		19.7917574Classical Michaelis-Menten
V = Etot.S.Kcat/Km+S		PIP2
DAG
IP3
  Mainly Homma et al JBC 263:14 1988 pp 6592. These parms are the Ca-stimulated form. Wahl et al JBC 267:15 10447-10456 1992 say that the tyrosine phosphorylated form has 7X higher affinity for substrate than control. The PIP2 levels in this model are rather low, at 10 uM.
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