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Enzyme List for pathway CaMKII (Pathway Number 80)

 Molecule Name/
Site Name 		Km (uM) kcat (1/s)Ratio
(k2/k3)		Enzyme TypeSubstrate Product
1 Enzyme Activity:
auton_286

Enzyme Molecule:
tot_autonomous_
CaMKII		00.54explicit E-S complexCaMKII-CaM
  • CaMKII-thr286*-C
    aM
    •   The autonomous rate has a slightly higher Km than the CaM-bound rate, but Vmax is the same. Hanson and Schulman 1992 Ann Rev Biochem 61:559-601 and Hanson and Schulman 1992 JBC 267(24):17216-17224
    2 Enzyme Activity:
    auton_305

    Enzyme Molecule:
    tot_autonomous_
    CaMKII    		064explicit E-S complexCaMKII-thr286
    		CaMKII***
      See Hanson and Schulman 1992 JBC 267(24):17216-17224 for afterburst rates of phosphorylation
    3 Enzyme Activity:
    CaM_act_286

    Enzyme Molecule:
    tot_CaM_CaMKII    		00.54explicit E-S complexCaMKII-CaM
  • CaMKII-thr286*-C
    aM
    •   See Hanson and Schulman 1992 JBC 267(24):17216-17224
    4 Enzyme Activity:
    CaM_act_305

    Enzyme Molecule:
    tot_CaM_CaMKII    		064explicit E-S complexCaMKII-thr286
    		CaMKII***
      Rates from autocamtide phosphorylation, from Hanson and Schulman JBC 267:24 17216-17224 1992. See especially Fig 5.
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