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Accession Type:
Network
Synaptic_
Network
Shared_Object_
Synaptic_
Network
PKC
PLA2
PLCbeta
 Molecule
 Enzyme
 Reaction
Gq
MAPK
Ras
EGFR
Sos
PLC_g
CaMKII
CaM
PP1
PP2B
PKA
AC
CaRegulation

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Molecule List for pathway PLCbeta (Pathway Number 73)

 Name Initial Conc. (uM) Volume (fL) Buffered
1Inositol01000Yes
    Very simplified degradation product of IP3. There is a very interesting and complex phosphorylation/dephosphorylation cascade on the inositol phosphates, but that is outside the scope of this model.
2PC00.0016667Yes
    Phosphatidylcholine is the main (around 55%) metabolic product of DAG, follwed by PE (around 25%). Ref is Welsh and Cabot, JCB35:231-245(1987)
3PLC0.81000No
    Total PLC = 0.8 uM see Ryu et al JBC 262 (26) pp 12511 1987
4PLC-Ca01000No
    Ca-bound form of PLCbeta. This form is moderately active. Reviewed in Sternweis et al 1992 Phil Trans Roy Soc. Lond.
5PLC-Ca-Gq01000No
    This should really be labelled Ca.GTP.Gq_alpha.PLC This is the activated form of the enzyme.
6PLC-Gq01000No
    Gq-bound form of PLC beta.


Pathway Details  Molecule List   Enzyme List   Reaction List  


Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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