| Name | Initial Conc. (uM) td> | Volume (fL) | Buffered |
1 | Inositol | 0 | 1000 | Yes |
| Very simplified degradation product of IP3. There is a very interesting and complex phosphorylation/dephosphorylation cascade on the inositol phosphates, but that is outside the scope of this model. |
2 | PC | 0 | 0.0016667 | Yes |
| Phosphatidylcholine is the main (around 55%) metabolic product of DAG, follwed by PE (around 25%). Ref is Welsh and Cabot, JCB35:231-245(1987) |
3 | PLC | 0.8 | 1000 | No |
| Total PLC = 0.8 uM see Ryu et al JBC 262 (26) pp 12511 1987 |
4 | PLC-Ca | 0 | 1000 | No |
| Ca-bound form of PLCbeta. This form is moderately active. Reviewed in Sternweis et al 1992 Phil Trans Roy Soc. Lond. |
5 | PLC-Ca-Gq | 0 | 1000 | No |
| This should really be labelled Ca.GTP.Gq_alpha.PLC This is the activated form of the enzyme. |
6 | PLC-Gq | 0 | 1000 | No |
| Gq-bound form of PLC beta. |