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Reaction List for pathway IP3-3K (Pathway Number 162)

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reactions is not considered.
  Name KfKbKdtauSubstrateProduct
1 3K*-bind-CaM49.9998
(uM^-1 s^-1)		0.1
(s^-1)		Kd(bf) = 0.002(uM)-IP3_3K*
CaM-Ca4
IP3_3K_CaM*
  Communi et al, EMBO J 16; 1997 phosphorylated 3kinase has 25 fold greater sensitivity to CaM binding than the non-phosphorylated enzyme (Kd of 2nM)
2 3K-bind-CaM19.2312
(uM^-1 s^-1)		1
(s^-1)		Kd(bf) = 0.052(uM)-IP3_3K
CaM-Ca4
IP3_3K_CaM
  Communi et al, EMBO J 16; 1997 non-phosphorylated 3kinase with low sensitivity to CaM binding (Kd = 52nM)
3 3k-CaM*-off45
(s^-1)		0.4148
(uM^-1 s^-1)		Kd(cb) = 0.0092(uM)-
  • 3kCaM*_ip3_
    cmplx
    		• IP4(1345)
    IP3_3K_CaM*
      Kf = Vmax for enzyme (Communi et al, EMBO J 16(8)) Vmax is such that enzyme activity is 9 fold above basal. Kb derived from Keq value when reaction free energy = -10 kJ/mol
    4 3k-CaM*-on80.358
    (uM^-1 s^-1)    		180
    (s^-1)    		Kd(bf) = 2.24(uM)-IP3(145)
    IP3_3K_CaM*
  • 3kCaM*_ip3_
    cmplx
    •   Rates from Km of enzyme Communi et al, EMBO J 16(8)
    5 3k-CaM-off10.5
    (s^-1)    		0.0968
    (uM^-1 s^-1)    		Kd(cb) = 0.0092(uM)-3kCaM_ip3_cmplx
    		IP4(1345)
    IP3_3K_CaM
      Kf = Vmax for enzyme: Erneux et al, Biochem 214; 1993 Enzyme is 2-2.5 fold more active than basal enzyme. Kb derived from equilibrium conditions for dG = -10 kJ/mol
    6 3k-CaM-on18.7497
    (uM^-1 s^-1)    		42.001
    (s^-1)    		Kd(bf) = 2.2401(uM)-IP3_3K_CaM
    IP3(145)
    		3kCaM_ip3_cmplx
      rates from Km for enzyme: Erneux et al, Biochem 214; 1993 Enzyme is 2-2.5 fold more active than ip3-3k, but Km is doubled.
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