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Reaction List for pathway CaMKII_PSD (Pathway Number 292)

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reactions is not considered.
  Name KfKbKdtauSubstrateProduct
1 back_10.3
(s^-1)		0
(#^-1 s^-1)		Not applicable**-CaMKII-PSD
CaMKII
NMDAR
  Rates set by the translocation experiments of Shen and Meyer, Science 1999. Note that this reaction also incorporates a translocation between compartments of different volumes.
2 back_20.3
(s^-1)		0
(#^-1 s^-1)		Not applicable**-
  • CaMKII-thr305-PS
    D
    		• CaMK-thr305
    NMDAR
      Same as for back_1
    3 CaMKII-bind-CaM-
    PSD    		49.9998
    (uM^-1 s^-1)    		0
    (s^-1)    		--CaMKII-PSD
    CaM-Ca4-PSD
    		CaMKII-CaM-PSD
    4 CaMKII-diss-CaM5
    (s^-1)    		0
    (uM^-1 s^-1)    		--CaMKII-CaM-PSD
    		CaM-Ca4-PSD
    CaMKII-PSD
    5 CaMKII-thr286-bi
    nd-CaM-PSD    		1000.02
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 0.0001(uM)-
  • CaMKII-thr286-PS
    D
    CaM-Ca4-PSD
  • CaMKII-thr286-Ca
    M-PSD
    •   Same values as for the main compartment Can the main compartment pool of Ca/CaM be used?
    6 Stoch_Basal_
    CaMKII_PSD    		1
    (s^-1)    		1
    (s^-1)    		Keq = 1(uM)0.5sec
  • basal_CaMKII_
    PSD_control
  • basal_CaMKII_
    PSD
    •   This reaction comes into play when stochastic calculations are used. If we do not have a stochastic step here then the levels of basal_CaMKII_PSD are just a fixed number, which is probably not a good representation of stochasticity. Having a reaction for the basal activity ensures that the basal activity too exhibits some fluctuations.
    7 transloc_10
    (#^-1 s^-1)    		0
    (s^-1)    		Not applicable**-CaMKII-CaM
    NMDAR
    		CaMKII-CaM-PSD
      Rates to match curve in fig2 from Shen and Meyer, Science 284:162-166(1999), calculated for 6:1 alpha:beta CaMKII heterodimers Note that this reaction also incorporates a translocation between compartments of different volumes.
    8 transloc_20
    (#^-1 s^-1)    		0
    (s^-1)    		Not applicable**-
  • CaMKII-thr286*-C
    aM
    NMDAR
  • CaMKII-thr286-Ca
    M-PSD
    •   Same as for transloc_1
    ** This is a trasport reation between compartments of different volumes. Therefore Kd is not applicable. Please Note Kf, Kb units are in number of molecules instead of concentration.
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