 |  |  PP1_CaMKII_PSDPP1_CaMKII_PSD |
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Reaction List for pathway CaMKII_PSD (Pathway Number 292) | | Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reactions is not considered. |
| | Name | Kf | Kb | Kd | tau | Substrate | Product | | 1 |
back_1 | kf
(s^-1) | 0
(#^-1 s^-1) | Not applicable** | - | CaMKII-PSD
| CaMKII
NMDAR
| | | Rates set by the translocation experiments of Shen and Meyer, Science 1999. Note that this reaction also incorporates a translocation between compartments of different volumes. | | 2 |
back_2 | kf
(s^-1) | 0
(#^-1 s^-1) | Not applicable** | - | CaMKII-thr305-PS
D
| CaMK-thr305
NMDAR
| | | Same as for back_1 | | 3 |
CaMKII-bind-CaM-
PSD | kf
(uM^-1 s^-1) | 0
(s^-1) | - | - | CaMKII-PSD
CaM-Ca4-PSD
| CaMKII-CaM-PSD
| | 4 |
CaMKII-diss-CaM | kf
(s^-1) | 0
(uM^-1 s^-1) | - | - | CaMKII-CaM-PSD
| CaM-Ca4-PSD
CaMKII-PSD
| | 5 |
CaMKII-thr286-bi
nd-CaM-PSD | kf
(uM^-1 s^-1) | 0.1
(s^-1) | Kd(bf) = 0.0001(uM) | - | CaMKII-thr286-PS
D
CaM-Ca4-PSD
| CaMKII-thr286-Ca
M-PSD
| | | Same values as for the main compartment Can the main compartment pool of Ca/CaM be used? | | 6 |
Stoch_Basal_
CaMKII_PSD | kf
(s^-1) | 1
(s^-1) | Keq = 1(uM) | 0.5sec | basal_CaMKII_
PSD_control
| basal_CaMKII_
PSD
| | | This reaction comes into play when stochastic calculations are used. If we do not have a stochastic step here then the levels of basal_CaMKII_PSD are just a fixed number, which is probably not a good representation of stochasticity. Having a reaction for the basal activity ensures that the basal activity too exhibits some fluctuations. | | 7 |
transloc_1 | kf
(#^-1 s^-1) | 0
(s^-1) | Not applicable** | - | CaMKII-CaM
NMDAR
| CaMKII-CaM-PSD
| | | Rates to match curve in fig2 from Shen and Meyer, Science 284:162-166(1999), calculated for 6:1 alpha:beta CaMKII heterodimers Note that this reaction also incorporates a translocation between compartments of different volumes. | | 8 |
transloc_2 | kf
(#^-1 s^-1) | 0
(s^-1) | Not applicable** | - | CaMKII-thr286*-C
aM
NMDAR
| CaMKII-thr286-Ca
M-PSD
| | | Same as for transloc_1 |
** This is a trasport reation between compartments of different volumes. Therefore Kd is not applicable. Please Note Kf, Kb units are in number of molecules instead of concentration.
Pathway Details Molecule List Enzyme List Reaction List
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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