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Reaction List for pathway PP1 (Pathway Number 82) | | Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reactions is not considered. |
| | Name | Kf | Kb | Kd | tau | Substrate | Product | | 1 |
dissoc-PP1-I1 | 1
(s^-1) | 0
(uM^-1 s^-1) | - | - | PP1-I1
| PP1-active
I1
| | | Assumption is that the affinity of the unphosphorylated form of I1 for PP1 is extremely weak and that the reaction is essentially all the way forward. The tau is fast at 1 sec. | | 2 |
Inact-PP1 | 499.98
(uM^-1 s^-1) | 0.1
(s^-1) | Kd(bf) = 0.0002(uM) | - | I1*
PP1-active
| PP1-I1*
| | | K inhib = 1nM from Cohen Ann Rev Bioch 1989, 4 nM from Foukes et al Assume 2 nM. kf /kb = 8.333e-4 The Kd used here is 0.2 nM. This is small, but unlikely to matter much as the affinity is so strong that the reaction will be all the way forward in either case. Tau < 1 min for inhibition. Stralfors 1985 Eur J Biochem 149:295-303 fig 8 pg 201. |
Pathway Details Molecule List Enzyme List Reaction List
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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