| Pathway Name | PKA |
| Pathway Entry Number | 84 |
| Accession Number | 16 |
| Accession Name | Synaptic_Network |
| Species | Generic mammalian |
| Tissue | Neuronal |
| CellCompartment | Synapse |
| Related Pathways | 17,
30,
135,
196,
220,
240,
250,
270,
277,
288,
326,
343,
361
|
| Notes | Protein kinase A. It has two regulatory and two catalytic subunits, represented here as R2C2. Each regulatory subunit binds two cAMPs. I also model an inhibitor of PKA which binds stoichiometrically and thus sharpens the response curve for PKA against cAMP. General reference: Taylor et al Ann Rev Biochem 1990 59:971-1005 Other references Ogreid and Doskeland 1983 Biochem 22:1686-1696 is a great, detailed paper. Also: Ogreid and Doskeland 1982 FEBS Lett 150(1):161-166 Ogreid et al 1983 JBC 258(2):1041-1049 Robinson-Steiner and Corbin 1983 JBC 258(2):1032-1040 Hasler et al 1992 FASEB J 6:2735-2741
|
