| |
Pathway Name
Pathway No. | Accession Name
Accession No. | Accession
Type | Pathway statistics | CamKII statistics | Source
Entry Date |
| 21 | Shared_Object_
CaMKII_noPKA_
model3
Pathway No. 257 | CaMKII_noPKA_
model3
Accession No. 62 | Network | Molecule = 33
Enzyme = 28
Reaction = 13
| Molecule = 14
Enzyme = 3
Reaction = 4
| Hayer A, Bhalla US PLoS PLoS Comput Biol. 2005 Jul;1(2):137-54. Epub 2005 Jul 29. ( Peer-reviewed publication )/
2005-07-19 00:00:00 |
| | #1Related Pathway: ------ |
| | This is the model of CaMKII bistability, model 3. It exhibits bistability in CaMKII activation due to autophosphorylation at the PSD and local saturation of PP1. This version of model 3 does not include the full PKA regulatory pathway, and instead has a predefined initial amount of active PKA. |
| | This pathway is part of accession 62 and is completely specified in the file acc62.g.
There is no separate files for just this pathway. |
|
| 22 | CaMKII
Pathway No. 258 | CaMKII_noPKA_
model3
Accession No. 62 | Network | Molecule = 8
Enzyme = 4
Reaction = 2
| Molecule = 7
Enzyme = 4
Reaction = 1
| Hayer A, Bhalla US PLoS PLoS Comput Biol. 2005 Jul;1(2):137-54. Epub 2005 Jul 29. ( Peer-reviewed publication )/
2005-07-19 00:00:00 |
| | #19Related Pathway:
13, 26, 80, 106, 121, 145, 159, 174, 202, 216, 235, 245, 264, 272, 282, 322, 339, 357 |
| | Main reference here is the review by Hanson and Schulman, Ann Rev Biochem 1992 vol 61 pp 559-601. Most of the mechanistic details and a few constants are derived from there. Many kinetics are from Hanson and Schulman JBC 267:24 17216-17224 1992. The enzs look a terrible mess. Actually it is just 3 reactions for diff sites, by 4 states of CaMKII, defined by the phosph state. |
| | This pathway is part of accession 62 and is completely specified in the file acc62.g.
There is no separate files for just this pathway. |
|
| 23 | Shared_Object_
CaMKII_model3
Pathway No. 263 | CaMKII_model3
Accession No. 63 | Network | Molecule = 36
Enzyme = 30
Reaction = 14
| Molecule = 14
Enzyme = 3
Reaction = 4
| Hayer A, Bhalla US PLoS Comput Biol. 2005 Jul;1(2):137-54. Epub 2005 Jul 29. ( Peer-reviewed publication )/
2005-07-19 00:00:00 |
| | #1Related Pathway: ------ |
| | This is the complete model of CaMKII bistability, model 3. It exhibits bistability in CaMKII activation due to autophosphorylation at the PSD and local saturation of PP1. This version of model 3 includes PKA regulatory input. This has little effect on the deterministic calculations, but the PKA pathway introduces a lot of noise which causes a difference in stochastic runs. |
| | This pathway is part of accession 63 and is completely specified in the file acc63.g.
There is no separate files for just this pathway. |
|
| 24 | CaMKII
Pathway No. 264 | CaMKII_model3
Accession No. 63 | Network | Molecule = 8
Enzyme = 4
Reaction = 2
| Molecule = 7
Enzyme = 4
Reaction = 1
| Hayer A, Bhalla US PLoS Comput Biol. 2005 Jul;1(2):137-54. Epub 2005 Jul 29. ( Peer-reviewed publication )/
2005-07-19 00:00:00 |
| | #19Related Pathway:
13, 26, 80, 106, 121, 145, 159, 174, 202, 216, 235, 245, 258, 272, 282, 322, 339, 357 |
| | Main reference here is the review by Hanson and Schulman, Ann Rev Biochem 1992 vol 61 pp 559-601. Most of the mechanistic details and a few constants are derived from there. Many kinetics are from Hanson and Schulman JBC 267:24 17216-17224 1992. The enzs look a terrible mess. Actually it is just 3 reactions for diff sites, by 4 states of CaMKII, defined by the phosph state. |
| | This pathway is part of accession 63 and is completely specified in the file acc63.g.
There is no separate files for just this pathway. |
|
| 25 | Shared_Object_
AMPAR_CaMKII_
strong_coupling
Pathway No. 271 | AMPAR_CaMKII_
strong_coupling
Accession No. 64 | Network | Molecule = 51
Enzyme = 148
Reaction = 16
| Molecule = 14
Enzyme = 19
Reaction = 4
| Hayer A, Bhalla US PLoS Comput Biol. 2005 Jul;1(2):137-54. Epub 2005 Jul 29. ( Peer-reviewed publication )/
2005-07-19 00:00:00 |
| | #1Related Pathway: ------ |
| | This is a model of tight coupling between the AMPAR trafficking bistability, and the CaMKII autophosphorylation bistability. In this model, the CaMKII activity is self sustaining only when AMPAR is turned on. Further, CaMKII turns on when AMPAR is turned on. |
| | This pathway is part of accession 64 and is completely specified in the file acc64.g.
There is no separate files for just this pathway. |
|
| 26 | CaMKII
Pathway No. 272 | AMPAR_CaMKII_
strong_coupling
Accession No. 64 | Network | Molecule = 8
Enzyme = 4
Reaction = 2
| Molecule = 7
Enzyme = 4
Reaction = 1
| Hayer A, Bhalla US PLoS Comput Biol. 2005 Jul;1(2):137-54. Epub 2005 Jul 29. ( Peer-reviewed publication )/
2005-07-19 00:00:00 |
| | #19Related Pathway:
13, 26, 80, 106, 121, 145, 159, 174, 202, 216, 235, 245, 258, 264, 282, 322, 339, 357 |
| | Main reference here is the review by Hanson and Schulman, Ann Rev Biochem 1992 vol 61 pp 559-601. Most of the mechanistic details and a few constants are derived from there. Many kinetics are from Hanson and Schulman JBC 267:24 17216-17224 1992. The enzs look a terrible mess. Actually it is just 3 reactions for diff sites, by 4 states of CaMKII, defined by the phosph state. |
| | This pathway is part of accession 64 and is completely specified in the file acc64.g.
There is no separate files for just this pathway. |
|
| 27 | Shared_Object_
AMPAR_CaMKII_
weak_coupling
Pathway No. 281 | AMPAR_CaMKII_
weak_coupling
Accession No. 65 | Network | Molecule = 30
Enzyme = 14
Reaction = 8
| Molecule = 0
Enzyme = 0
Reaction = 0
| Hayer A, Bhalla US PLoS Comput Biol. 2005 Jul;1(2):137-54. Epub 2005 Jul 29. ( Peer-reviewed publication )/
2005-07-21 00:00:00 |
| | #1Related Pathway: ------ |
| | This is a model of weak coupling between the AMPAR traffikcing bistability, and the CaMKII autophosphorylation bistability. In this model, there are three stable states: Both off, AMPAR on, or both on. The fourth possible state: CaMKII on but AMPAR off, is not truly stable, since over the course of hours the AMPAR also turns on. |
| | This pathway is part of accession 65 and is completely specified in the file acc65.g.
There is no separate files for just this pathway. |
|
| 28 | CaMKII
Pathway No. 282 | AMPAR_CaMKII_
weak_coupling
Accession No. 65 | Network | Molecule = 11
Enzyme = 4
Reaction = 2
| Molecule = 10
Enzyme = 4
Reaction = 1
| Hayer A, Bhalla US PLoS Comput Biol. 2005 Jul;1(2):137-54. Epub 2005 Jul 29. ( Peer-reviewed publication )/
2005-07-21 00:00:00 |
| | #19Related Pathway:
13, 26, 80, 106, 121, 145, 159, 174, 202, 216, 235, 245, 258, 264, 272, 322, 339, 357 |
| | Main reference here is the review by Hanson and Schulman, Ann Rev Biochem 1992 vol 61 pp 559-601. Most of the mechanistic details and a few constants are derived from there. Many kinetics are from Hanson and Schulman JBC 267:24 17216-17224 1992. The enzs look a terrible mess. Actually it is just 3 reactions for diff sites, by 4 states of CaMKII, defined by the phosph state. |
| | This pathway is part of accession 65 and is completely specified in the file acc65.g.
There is no separate files for just this pathway. |
|
| 29 | PP1_CaMKII_PSD
Pathway No. 291 | AMPAR_CaMKII_
weak_coupling
Accession No. 65 | Network | Molecule = 1
Enzyme = 5
Reaction = 0
| Molecule = 1
Enzyme = 5
Reaction = 0
| Hayer A, Bhalla US PLoS Comput Biol. 2005 Jul;1(2):137-54. Epub 2005 Jul 29. ( Peer-reviewed publication )/
2005-07-21 00:00:00 |
| | #1Related Pathway: ------ |
| | This is a model of weak coupling between the AMPAR traffikcing bistability, and the CaMKII autophosphorylation bistability. In this model, there are three stable states: Both off, AMPAR on, or both on. The fourth possible state: CaMKII on but AMPAR off, is not truly stable, since over the course of hours the AMPAR also turns on. |
| | This pathway is part of accession 65 and is completely specified in the file acc65.g.
There is no separate files for just this pathway. |
|
| 30 | CaMKII_PSD
Pathway No. 292 | AMPAR_CaMKII_
weak_coupling
Accession No. 65 | Network | Molecule = 14
Enzyme = 22
Reaction = 8
| Molecule = 11
Enzyme = 19
Reaction = 4
| Hayer A, Bhalla US PLoS Comput Biol. 2005 Jul;1(2):137-54. Epub 2005 Jul 29. ( Peer-reviewed publication )/
2005-07-21 00:00:00 |
| | #1Related Pathway: ------ |
| | This is a model of weak coupling between the AMPAR traffikcing bistability, and the CaMKII autophosphorylation bistability. In this model, there are three stable states: Both off, AMPAR on, or both on. The fourth possible state: CaMKII on but AMPAR off, is not truly stable, since over the course of hours the AMPAR also turns on. |
| | This pathway is part of accession 65 and is completely specified in the file acc65.g.
There is no separate files for just this pathway. |
|
| 31 | CaMKII
Pathway No. 322 | Ajay_Bhalla_
2004_PKM_Tuning
Accession No. 76 | Network | Molecule = 8
Enzyme = 4
Reaction = 3
| Molecule = 7
Enzyme = 4
Reaction = 1
| Ajay SM, Bhalla US. Eur J Neurosci. 2004 Nov;20(10):2671-80. ( Peer-reviewed publication )/
2006-12-12 00:00:00 |
| | #19Related Pathway:
13, 26, 80, 106, 121, 145, 159, 174, 202, 216, 235, 245, 258, 264, 272, 282, 339, 357 |
| | Main reference here is the review by Hanson and Schulman, Ann Rev Biochem 1992 vol 61 pp 559-601. Most of the mechanistic details and a few constants are derived from there. Many kinetics are from Hanson and Schulman JBC 267:24 17216-17224 1992. The enzs look a terrible mess. Actually it is just 3 reactions for diff sites, by 4 states of CaMKII, defined by the phosph state. |
| | This pathway is part of accession 76 and is completely specified in the file acc76.g.
There is no separate files for just this pathway. |
|
| 32 | CaMKII
Pathway No. 339 | Ajay_Bhalla_
2004_PKM_MKP3_
Tuning
Accession No. 77 | Network | Molecule = 8
Enzyme = 4
Reaction = 3
| Molecule = 7
Enzyme = 4
Reaction = 1
| Ajay SM, Bhalla US. Eur J Neurosci. 2004 Nov;20(10):2671-80 ( Peer-reviewed publication )/
2006-12-12 00:00:00 |
| | #19Related Pathway:
13, 26, 80, 106, 121, 145, 159, 174, 202, 216, 235, 245, 258, 264, 272, 282, 322, 357 |
| | Main reference here is the review by Hanson and Schulman, Ann Rev Biochem 1992 vol 61 pp 559-601. Most of the mechanistic details and a few constants are derived from there. Many kinetics are from Hanson and Schulman JBC 267:24 17216-17224 1992. The enzs look a terrible mess. Actually it is just 3 reactions for diff sites, by 4 states of CaMKII, defined by the phosph state. |
| | This pathway is part of accession 77 and is completely specified in the file acc77.g.
There is no separate files for just this pathway. |
|
| 33 | CaMKII
Pathway No. 357 | Ajay_Bhalla_
2004_Feedback_
Tuning
Accession No. 78 | Network | Molecule = 8
Enzyme = 4
Reaction = 3
| Molecule = 7
Enzyme = 4
Reaction = 1
| Ajay SM, Bhalla US. Eur J Neurosci. 2004 Nov;20(10):2671-80. ( Peer-reviewed publication )/
2006-12-12 00:00:00 |
| | #19Related Pathway:
13, 26, 80, 106, 121, 145, 159, 174, 202, 216, 235, 245, 258, 264, 272, 282, 322, 339 |
| | Main reference here is the review by Hanson and Schulman, Ann Rev Biochem 1992 vol 61 pp 559-601. Most of the mechanistic details and a few constants are derived from there. Many kinetics are from Hanson and Schulman JBC 267:24 17216-17224 1992. The enzs look a terrible mess. Actually it is just 3 reactions for diff sites, by 4 states of CaMKII, defined by the phosph state. |
| | This pathway is part of accession 78 and is completely specified in the file acc78.g.
There is no separate files for just this pathway. |
|
| 34 | Shared_Object_
CaMKIII
Pathway No. 1093 | CaMKIII
Accession No. 90 | Network | Molecule = 15
Enzyme = 5
Reaction = 3
| Molecule = 4
Enzyme = 4
Reaction = 2
| Jain P, and Bhalla, U.S. PLoS Comput Biol. 2009 Feb;5(2). ( Peer-reviewed publication )/
2009-02-12 00:00:00 |
| | #1Related Pathway: ------ |
| | CaMKIII is activated by Ca2+ and inactivated by S6K. Since CaMKIII inhibits eEF2, the net effect of Ca2+ on elongation is inhibitory and of S6K is excitatory |
| | This pathway is part of accession 90 and is completely specified in the file acc90.g.
There is no separate file for just this pathway. |
| Format | File | | Native Format (GENESIS format) | acc90.g |
|
or Pathway 