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Molecule Parameter List for MAPKK*

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by color.

Statistics

MAPKK* participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	0	2	1	1	0	0

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
fig2_egfr	1	Network	Shared_Object_fig2_egfr,  PKC,  PLA2,   PLCbeta,  Gq,  MAPK,   Ras,  EGFR,  Sos,   PLC_g,  CaRegulation
This network was used to generate figure 2 in Bhalla US and Iyengar R. Science (1999) 283(5400):381-7. It consists of the MAPK cascade in a feedback loop with PKC, and receives input from the EGFR in the synapse. Demonstration script files for generating the figures in the paper, including figure 2, are available here.

MAPKK* acting as a Molecule in  fig2_egfr Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
MAPKK*	fig2_egfr Accession No. : 1	MAPK Pathway No. : 6	0	1000	No

MAPKK* acting as an Enzyme in  fig2_egfr Network

	Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
1	MAPKK* / MAPKKtyr	fig2_egfr Accession No. : 1	MAPK Pathway No. : 6	0.0462963	0.15	4	explicit E-S complex	Substrate MAPK Product MAPK-tyr
2	MAPKK* / MAPKKthr	fig2_egfr Accession No. : 1	MAPK Pathway No. : 6	0.0462963	0.15	4	explicit E-S complex	Substrate MAPK-tyr Product MAPK*

MAPKK* acting as a Substrate for an Enzyme in  fig2_egfr Network

Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
PPhosphatase2A  / MAPKK-deph	fig2_egfr Accession No. : 1	Shared_Object_ fig2_egfr Pathway No. : 1	15.6566	6	4.16667	explicit E-S complex	Substrate MAPKK* Product MAPKK-ser

MAPKK* acting as a Product of an Enzyme in  fig2_egfr Network

Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
Raf-GTP-Ras*  / Raf-GTP-Ras*.2	fig2_egfr Accession No. : 1	MAPK Pathway No. : 6	0.159091	0.105	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK*