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Molecule Parameter List for MAPKK* | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by  color. | | Statistics |
Accession and Pathway Details | |
| Accession Name | Accession No. | Accession Type | Pathway Link | | fig2_egfr | 1 | Network |
Shared_Object_fig2_egfr, PKC, PLA2,
PLCbeta, Gq, MAPK,
Ras, EGFR, Sos,
PLC_g, CaRegulation | This network was used to generate figure 2 in Bhalla US and Iyengar R. Science (1999) 283(5400):381-7. It consists of the MAPK cascade in a feedback loop with PKC, and receives input from the EGFR in the synapse.
Demonstration script files for generating the figures in the paper, including figure 2, are available here. |
MAPKK* acting as a Molecule in fig2_egfr Network
| Name | Accession Name | Pathway Name | Initial Conc.
(uM) | Volume
(fL) | Buffered | | MAPKK* | fig2_egfr
Accession No. : 1 | MAPK
Pathway No. : 6 | 0 | 1000 | No | | |
MAPKK* acting as an Enzyme in fig2_egfr Network
| | Enzyme Molecule /
Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents | | 1 | MAPKK* /
MAPKKtyr
| fig2_egfr
Accession No. : 1 | MAPK
Pathway No. : 6 | 0.0462963 | 0.15 | 4 | explicit E-S complex | Substrate
MAPK
Product
MAPK-tyr
| | 2 | MAPKK* /
MAPKKthr
| fig2_egfr
Accession No. : 1 | MAPK
Pathway No. : 6 | 0.0462963 | 0.15 | 4 | explicit E-S complex | Substrate
MAPK-tyr
Product
MAPK*
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MAPKK* acting as a Substrate for an Enzyme in fig2_egfr Network
MAPKK* acting as a Product of an Enzyme in fig2_egfr Network
Enzyme Molecule /
Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents | Raf-GTP-Ras* /
Raf-GTP-Ras*.2 | fig2_egfr
Accession No. : 1 | MAPK
Pathway No. : 6 | 0.159091 | 0.105 | 4 | explicit E-S complex | Substrate
MAPKK-ser
Product
MAPKK*
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| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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