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Molecule Parameter List for Ca.PLC_g | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by  color. | | Statistics |
Accession and Pathway Details | |
| Accession Name | Accession No. | Accession Type | Pathway Link | | fig2_egfr | 1 | Network |
Shared_Object_fig2_egfr, PKC, PLA2,
PLCbeta, Gq, MAPK,
Ras, EGFR, Sos,
PLC_g, CaRegulation | This network was used to generate figure 2 in Bhalla US and Iyengar R. Science (1999) 283(5400):381-7. It consists of the MAPK cascade in a feedback loop with PKC, and receives input from the EGFR in the synapse.
Demonstration script files for generating the figures in the paper, including figure 2, are available here. |
Ca.PLC_g acting as a Molecule in fig2_egfr Network
| Name | Accession Name | Pathway Name | Initial Conc.
(uM) | Volume
(fL) | Buffered | | Ca.PLC_g | fig2_egfr
Accession No. : 1 | PLC_g
Pathway No. : 10 | 0 | 1000 | No | | |
Ca.PLC_g acting as an Enzyme in fig2_egfr Network
Enzyme Molecule /
Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents | Ca.PLC_g /
PIP2_hydrolysis
| fig2_egfr
Accession No. : 1 | PLC_g
Pathway No. : 10 | 97.2222 | 14 | 4 | Classical Michaelis-Menten
V = Etot.S.Kcat/Km+S | Substrate
PIP2
Product
DAG
IP3
|
Ca.PLC_g acting as a Substrate for an Enzyme in fig2_egfr Network
Enzyme Molecule /
Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents | L.EGFR /
phosph_PLC_g | fig2_egfr
Accession No. : 1 | EGFR
Pathway No. : 8 | 0.333333 | 0.2 | 4 | explicit E-S complex | Substrate
Ca.PLC_g
Product
Ca.PLC_g*
|
Ca.PLC_g acting as a Product in a reaction in fig2_egfr Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| | Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | | 1 | Ca_act_PLC_g | fig2_egfr
Accession No. : 1 | PLC_g
Pathway No. : 10 | 180
(uM^-1 s^-1) | 10
(s^-1) | Kd(bf) = 0.0556(uM) | - | Substrate
Ca
PLC_g
Product
Ca.PLC_g
| | 2 | dephosph_PLC_g | fig2_egfr
Accession No. : 1 | PLC_g
Pathway No. : 10 | 0.05
(s^-1) | 0
(s^-1) | - | - | Substrate
Ca.PLC_g*
Product
Ca.PLC_g
|
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
This Copyright is applied to ensure that the contents of this database remain freely available. Please see FAQ for details. |
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