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Molecule Parameter List for Ca.PLC_g

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by color.

Statistics

Ca.PLC_g participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	0	1	1	0	0	2

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
fig2_egfr	1	Network	Shared_Object_fig2_egfr,  PKC,  PLA2,   PLCbeta,  Gq,  MAPK,   Ras,  EGFR,  Sos,   PLC_g,  CaRegulation
This network was used to generate figure 2 in Bhalla US and Iyengar R. Science (1999) 283(5400):381-7. It consists of the MAPK cascade in a feedback loop with PKC, and receives input from the EGFR in the synapse. Demonstration script files for generating the figures in the paper, including figure 2, are available here.

Ca.PLC_g acting as a Molecule in  fig2_egfr Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
Ca.PLC_g	fig2_egfr Accession No. : 1	PLC_g Pathway No. : 10	0	1000	No

Ca.PLC_g acting as an Enzyme in  fig2_egfr Network

Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
Ca.PLC_g / PIP2_hydrolysis	fig2_egfr Accession No. : 1	PLC_g Pathway No. : 10	97.2222	14	4	Classical Michaelis-Menten V = Etot.S.Kcat/Km+S	Substrate PIP2 Product DAG IP3

Ca.PLC_g acting as a Substrate for an Enzyme in  fig2_egfr Network

Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
L.EGFR  / phosph_PLC_g	fig2_egfr Accession No. : 1	EGFR Pathway No. : 8	0.333333	0.2	4	explicit E-S complex	Substrate Ca.PLC_g Product Ca.PLC_g*

Ca.PLC_g acting as a Product in a reaction in  fig2_egfr Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

	Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
1	Ca_act_PLC_g	fig2_egfr Accession No. : 1	PLC_g Pathway No. : 10	180 (uM^-1 s^-1)	10 (s^-1)	Kd(bf) = 0.0556(uM)	-	Substrate Ca PLC_g Product Ca.PLC_g
2	dephosph_PLC_g	fig2_egfr Accession No. : 1	PLC_g Pathway No. : 10	0.05 (s^-1)	0 (s^-1)	-	-	Substrate Ca.PLC_g* Product Ca.PLC_g