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Molecule Parameter List for PLA2-Ca* | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by  color. | | Statistics |
Accession and Pathway Details | |
| Accession Name | Accession No. | Accession Type | Pathway Link | Synaptic_
Network | 16 | Network |
Shared_Object_Synaptic_Network, PKC, PLA2,
PLCbeta, Gq, MAPK,
Ras, EGFR, Sos,
PLC_g, CaMKII, CaM,
PP1, PP2B, PKA,
AC, CaRegulation | This model is an annotated version of the synaptic signaling network.
The primary reference is Bhalla US and Iyengar R. Science (1999) 283(5400):381-7 but several of the model pathways have been updated.
Bhalla US Biophys J. 2002 Aug;83(2):740-52
Bhalla US J Comput Neurosci. 2002 Jul-Aug;13(1):49-62 |
PLA2-Ca* acting as a Molecule in Synaptic_Network Network
| Name | Accession Name | Pathway Name | Initial Conc.
(uM) | Volume
(fL) | Buffered | | PLA2-Ca* | Synaptic_
Network
Accession No. : 16 | PLA2
Pathway No. : 72 | 0 | 1000 | No | | The generic Ca-activated form ofPLA2. Leslie and Channon 1990 BBA 1045:261. |
PLA2-Ca* acting as an Enzyme in Synaptic_Network Network
Enzyme Molecule /
Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents | PLA2-Ca* /
kenz
| Synaptic_
Network
Accession No. : 16 | PLA2
Pathway No. : 72 | 20 | 5.4 | 4 | explicit E-S complex | Substrate
APC
Product
AA
| | Based on Leslie and Channon 1990 BBA 1045:261, in relation to the other PLA2 inputs (not including MAPK). Ca alone is rather a weak input. |
PLA2-Ca* acting as a Substrate in a reaction in Synaptic_Network Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| | Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | | 1 | PIP2-Ca-PLA2-act | Synaptic_
Network
Accession No. : 16 | PLA2
Pathway No. : 72 | 0.012
(uM^-1 s^-1) | 0.1
(s^-1) | Kd(bf) = 8.3333(uM) | - | Substrate
PLA2-Ca*
temp-PIP2
Product
PIP2-Ca-PLA2*
| | | Synergistic activation of PLA2 by Ca and PIP2. Again from Leslie and Channon 1990 BBA 1045:261 | | 2 | DAG-Ca-PLA2-act | Synaptic_
Network
Accession No. : 16 | PLA2
Pathway No. : 72 | 0.003
(uM^-1 s^-1) | 4
(s^-1) | Kd(bf) = 1333.3333(uM) | - | Substrate
DAG
PLA2-Ca*
Product
DAG-Ca-PLA2*
| | | Synergistic activation of PLA2 by Ca and DAG. Based on Leslie and Channon 1990 BBA 1045:261 The Kd is rather large and may reflect the complications in measuring DAG. For this model it is not critical since DAG is held fixed. |
PLA2-Ca* acting as a Product in a reaction in Synaptic_Network Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | | PLA2-Ca-act | Synaptic_
Network
Accession No. : 16 | PLA2
Pathway No. : 72 | 1
(uM^-1 s^-1) | 0.1
(s^-1) | Kd(bf) = 0.1(uM) | - | Substrate
Ca
PLA2-cytosolic
Product
PLA2-Ca*
| | Direct activation of PLA2 by Ca. From Leslie and Channon BBA 1045 (1990) 261-270 fig6 pp267. |
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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