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Molecule Parameter List for PP1-I1 | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by  color. | | Statistics |
Accession and Pathway Details | |
| Accession Name | Accession No. | Accession Type | Pathway Link | Synaptic_
Network | 16 | Network |
Shared_Object_Synaptic_Network, PKC, PLA2,
PLCbeta, Gq, MAPK,
Ras, EGFR, Sos,
PLC_g, CaMKII, CaM,
PP1, PP2B, PKA,
AC, CaRegulation | This model is an annotated version of the synaptic signaling network.
The primary reference is Bhalla US and Iyengar R. Science (1999) 283(5400):381-7 but several of the model pathways have been updated.
Bhalla US Biophys J. 2002 Aug;83(2):740-52
Bhalla US J Comput Neurosci. 2002 Jul-Aug;13(1):49-62 |
PP1-I1 acting as a Molecule in Synaptic_Network Network
| Name | Accession Name | Pathway Name | Initial Conc.
(uM) | Volume
(fL) | Buffered | | PP1-I1 | Synaptic_
Network
Accession No. : 16 | PP1
Pathway No. : 82 | 0 | 1000 | No | | This form is bound to the non-phosphorylated inibitory subunit and is prone to dissociate. Cohen 1989 Ann Rev biochem 58:453-508 |
PP1-I1 acting as a Product of an Enzyme in Synaptic_Network Network
| | Enzyme Molecule /
Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents | | 1 | CaM(Ca)n-CaNAB /
dephosph-PP1-I* | Synaptic_
Network
Accession No. : 16 | Shared_Object_
Synaptic_
Network
Pathway No. : 70 | 4.97076 | 0.34 | 4 | explicit E-S complex | Substrate
PP1-I1*
Product
PP1-I1
| | | Liu and Storm JBC 1989 264(22):12800-12804 say Km ~ 5 uM, Vmax = 256 nmol/min/mg ~ 0.34/sec | | 2 | PP2A /
PP2A-dephosph-PP
1-I*
| Synaptic_
Network
Accession No. : 16 | Shared_Object_
Synaptic_
Network
Pathway No. : 70 | 7.82828 | 6 | 4.16667 | explicit E-S complex | Substrate
PP1-I1*
Product
PP1-I1
| | | PP2A does most of the dephosph of I1 at basal Ca levels. See the review by Cohen in Ann Rev Biochem 1989 58:453-508 I use a Km twice that for the preferred substrates of PP2A. Here I assume that the dephosph of the PP1-bound form of I1* will proceed at the same rate as the unbound I1*. |
PP1-I1 acting as a Substrate in a reaction in Synaptic_Network Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | | dissoc-PP1-I1 | Synaptic_
Network
Accession No. : 16 | PP1
Pathway No. : 82 | 1
(s^-1) | 0
(uM^-1 s^-1) | - | - | Substrate
PP1-I1
Product
I1
PP1-active
| | Assumption is that the affinity of the unphosphorylated form of I1 for PP1 is extremely weak and that the reaction is essentially all the way forward. The tau is fast at 1 sec. |
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
This Copyright is applied to ensure that the contents of this database remain freely available. Please see FAQ for details. |
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