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Molecule Parameter List for CaMCa2-CANAB

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by color.

Statistics

CaMCa2-CANAB participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	1	0	0	0	0	1

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
Synaptic_ Network	16	Network	Shared_Object_Synaptic_Network,  PKC,  PLA2,   PLCbeta,  Gq,  MAPK,   Ras,  EGFR,  Sos,   PLC_g,  CaMKII,  CaM,   PP1,  PP2B,  PKA,   AC,  CaRegulation
This model is an annotated version of the synaptic signaling network. The primary reference is Bhalla US and Iyengar R. Science (1999) 283(5400):381-7 but several of the model pathways have been updated. Bhalla US Biophys J. 2002 Aug;83(2):740-52 Bhalla US J Comput Neurosci. 2002 Jul-Aug;13(1):49-62

CaMCa2-CANAB acting as a Molecule in  Synaptic_Network Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
CaMCa2-CANAB	Synaptic_ Network Accession No. : 16	PP2B Pathway No. : 83	0	1000	No
Ca2.CaM.Ca4.CaNAB The CaM has only 2 calciums attached, but CaNAB has all 4. This contributes equally to enzyme activity along with the Ca3 and Ca4 forms.

CaMCa2-CANAB acting as a Summed Molecule in  Synaptic_Network Network

Accession Name	Pathway Name	Target	Input
Synaptic_ Network Accession No. : 16	Shared_Object_ Synaptic_ Network Pathway No. : 70	CaM(Ca)n-CaNAB	CaMCa4-CaNAB CaMCa3-CaNAB CaMCa2-CANAB
This pool sums the levels of the CaM.Ca2.CaNAB, CaM.Ca3.CaNAB and CaM.Ca4.CaNAB pools.

CaMCa2-CANAB acting as a Product in a reaction in  Synaptic_Network Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
CaM-Ca2-bind-CaN AB	Synaptic_ Network Accession No. : 16	PP2B Pathway No. : 83	0.24 (uM^-1 s^-1)	1 (s^-1)	Kd(bf) = 4.1667(uM)	-	Substrate CaM-TR2-Ca2 CaNAB-Ca4 Product CaMCa2-CANAB
Based on Stemmer and Klee 1994 Biochem 33:6859-6866 This model is actually a simplification of the detail they report. In this model the Ca-binding affinity of CaM is not changed by binding to CaN. Rates here come from a detailed-balance argument. The reference rate is for CaMCa4 binding to CaNAB. This rate should be 1/2500 of that.