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Accession Type:
Network
mkp1_feedback_
effects
Shared_Object_
mkp1_feedback_
effects
Sos
PKC
 Molecule
 Reaction
MAPK
PLA2
Ras
PDGFR

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Parameters for PKC (Pathway Number 34)

Pathway Layout

Pathway Basic Parameters

Pathway NamePKC
Pathway Entry Number 34
Accession Number 4
Accession Name mkp1_feedback_effects
Species Generic mammalian
Tissue NIH 3T3 Expression
CellCompartmentSurface - nucleus
Related Pathways 2, 20, 55, 60, 71, 108, 123, 138, 147, 161, 181, 200, 207, 313, 330, 348, 364, 370, 376, 383, 389, 395, 401, 408, 414, 420, 426, 431, 437, 443, 449, 455, 461, 467, 473, 479, 485, 491, 497, 503, 509, 515, 521, 527, 534, 540, 546, 552, 558, 564, 570, 576, 582, 588, 594, 600, 606, 612, 618, 624, 630, 636, 642, 648, 654, 660, 666, 672, 678, 685, 691, 698, 703, 709, 715, 721, 727, 733, 739, 745, 751, 757, 763, 769, 775, 781, 787, 793, 799, 805, 811, 817, 823, 829, 835, 841, 847, 853, 859, 865, 871, 877, 883, 889, 895, 901, 907, 913, 919, 927, 932, 938, 944, 950, 956, 963, 969, 974, 981, 987, 993, 999, 1004, 1010, 1016, 1022, 1028, 1034, 1040, 1046, 1052, 1058, 1064, 1104
Notes Protein Kinase C. This module represents a weighted average of the alpha, beta and gamma isoforms. It takes inputs from Ca, DAG (Diacyl Glycerol) and AA (arachidonic acid). Regulation parameters are largely from Schaechter and Benowitz 1993 J Neurosci 13(10):4361 who use synaptosomes from mammalian brain and in one paper look at all three inputs. Shinomura et al 1991 PNAS 88:5149-5153 is also a useful source of data and helps to tighten the DAG inputs. General reviews include Azzi et al 1992 Eur J Bioch 208:541 and Nishizuka 1988, Nature 334:661 Concentration info from Kikkawa et al 1982 JBC 257(22):13341 The process of parameterization is described in detail in several places. See Supplementary notes to Bhalla and Iyengar 1999 Science 284:92-96, available at the site http://www.ncbs.res.in/~bhalla/ltploop/pkc_example.html The parameterization is also described in a book chapter: Bhalla, 2000: Simulations of Biochemical Signaling in Computational Neuroscience: Realistic Modeling for Experimentalists. Ed. E. De Schutter. CRC Press.

Statistics

Enzyme sites
11
0
10

Conversion format

This pathway is part of accession 4 and is completely specified in the file acc4.g.
There is no separate files for just this pathway.
FormatFile
Native Format (GENESIS format)    acc4.g   
GENESIS Format (Annotated version)    Anno_acc4.g   
MATLAB format    acc4.m   
SBML format    acc4.xml   


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Database compilation and code copyright (C) 2005, Upinder S. Bhalla and NCBS/TIFR
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