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Accession Type:
Network
fig2_egfr
Shared_Object_
fig2_egfr
 Molecule
 Enzyme
 Reaction
PKC
PLA2
PLCbeta
Gq
MAPK
Ras
EGFR
Sos
PLC_g
CaRegulation

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Enzyme List for pathway Shared_Object_fig2_egfr (Pathway Number 1)

 Molecule Name/
Site Name 		Km (uM) kcat (1/s)Ratio
(k2/k3)		Enzyme TypeSubstrate Product
1 Enzyme Activity:
craf**-deph

Enzyme Molecule:
PPhosphatase2A		15.656664.16667explicit E-S complexcraf-1**
craf-1*
2 Enzyme Activity:
craf-deph

Enzyme Molecule:
PPhosphatase2A		15.656664.16667explicit E-S complexcraf-1*
craf-1
3 Enzyme Activity:
MAPK*

Enzyme Molecule:
MAPK*		25.641204explicit E-S complexPLA2-cytosolic
PLA2*
4 Enzyme Activity:
MAPK*-feedback

Enzyme Molecule:
MAPK*		25.641104explicit E-S complexcraf-1*
craf-1**
5 Enzyme Activity:
MAPKK-deph

Enzyme Molecule:
PPhosphatase2A		15.656664.16667explicit E-S complexMAPKK*
MAPKK-ser
6 Enzyme Activity:
MAPKK-deph-ser

Enzyme Molecule:
PPhosphatase2A		15.656664.16667explicit E-S complexMAPKK-ser
MAPKK
7 Enzyme Activity:
MKP1-thr-deph

Enzyme Molecule:
MKP-1		0.066666714explicit E-S complexMAPK*
MAPK-tyr
8 Enzyme Activity:
MKP1-tyr-deph

Enzyme Molecule:
MKP-1		0.066666714explicit E-S complexMAPK-tyr
MAPK
9 Enzyme Activity:
phosph_Sos

Enzyme Molecule:
MAPK*		2.5641104explicit E-S complexSos
Sos*
10 Enzyme Activity:
PKA-phosph-GEF

Enzyme Molecule:
PKA-active		7.594explicit E-S complexinact-GEF
inact-GEF*
11 Enzyme Activity:
PKC-act-GEF

Enzyme Molecule:
PKC-active		3.3333344explicit E-S complexinact-GEF
GEF*
12 Enzyme Activity:
PKC-act-raf

Enzyme Molecule:
PKC-active		66.666744explicit E-S complexcraf-1
craf-1*
13 Enzyme Activity:
PKC-inact-GAP

Enzyme Molecule:
PKC-active		3.3333344explicit E-S complexGAP
GAP*
14 Enzyme Activity:
Sos.Ras_GEF

Enzyme Molecule:
Shc*.Sos.Grb2		0.5050510.024explicit E-S complexGDP-Ras
GTP-Ras


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Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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