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Accession Type:
Network
fig4_synapse
Shared_Object_
fig4_synapse
 Molecule
 Enzyme
 Reaction
PKC
PLA2
PLCbeta
Gq
MAPK
Ras
CaMKII
CaM
PP1
PP2B
PKA
AC

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Enzyme List for pathway Shared_Object_fig4_synapse (Pathway Number 19)

 Molecule Name/
Site Name 		Km (uM) kcat (1/s)Ratio
(k2/k3)		Enzyme TypeSubstrate Product
1 Enzyme Activity:
craf**-deph

Enzyme Molecule:
PPhosphatase2A		15.656664.16667explicit E-S complexcraf-1**
craf-1*
2 Enzyme Activity:
craf-deph

Enzyme Molecule:
PPhosphatase2A		15.656664.16667explicit E-S complexcraf-1*
craf-1
3 Enzyme Activity:
Deph-thr286

Enzyme Molecule:
PP1-active		5.099070.354explicit E-S complex
  • CaMKII-thr286*-C
    aM
    		• CaMKII-CaM
    4 Enzyme Activity:
    Deph-thr286c

    Enzyme Molecule:
    PP1-active    		5.099070.354explicit E-S complexCaMKII***
    		CaMK-thr306
    5 Enzyme Activity:
    Deph-thr305

    Enzyme Molecule:
    PP1-active    		5.099070.354explicit E-S complexCaMKII***
    		CaMKII-thr286
    6 Enzyme Activity:
    Deph-thr306

    Enzyme Molecule:
    PP1-active    		5.099070.354explicit E-S complexCaMK-thr306
    		CaMKII
    7 Enzyme Activity:
    dephosph-PP1-I*

    Enzyme Molecule:
    CaM(Ca)n-CaNAB    		4.970760.344explicit E-S complexPP1-I1*
    		PP1-I1
    8 Enzyme Activity:
    dephosph_inhib1

    Enzyme Molecule:
    CaM(Ca)n-CaNAB    		4.970760.344explicit E-S complexI1*
    		I1
    9 Enzyme Activity:
    dephosph_
    inhib1_noCaM

    Enzyme Molecule:
    CaNAB-Ca4    		4.970760.0344explicit E-S complexI1*
    		I1
    10 Enzyme Activity:
    dephosph_
    neurogranin

    Enzyme Molecule:
    CaM(Ca)n-CaNAB    		10.0120.673.98507explicit E-S complexneurogranin*
    		neurogranin
    11 Enzyme Activity:
    Deph_thr286b

    Enzyme Molecule:
    PP1-active    		5.099070.354explicit E-S complexCaMKII-thr286
    		CaMKII
    12 Enzyme Activity:
    MAPK*

    Enzyme Molecule:
    MAPK*    		25.641204explicit E-S complexPLA2-cytosolic
    		PLA2*
    13 Enzyme Activity:
    MAPK*-feedback

    Enzyme Molecule:
    MAPK*    		25.641104explicit E-S complexcraf-1*
    		craf-1**
    14 Enzyme Activity:
    MAPKK-deph

    Enzyme Molecule:
    PPhosphatase2A    		15.656664.16667explicit E-S complexMAPKK*
    		MAPKK-ser
    15 Enzyme Activity:
    MAPKK-deph-ser

    Enzyme Molecule:
    PPhosphatase2A    		15.656664.16667explicit E-S complexMAPKK-ser
    		MAPKK
    16 Enzyme Activity:
    MKP1-thr-deph

    Enzyme Molecule:
    MKP-1    		0.066666714explicit E-S complexMAPK*
    		MAPK-tyr
    17 Enzyme Activity:
    MKP1-tyr-deph

    Enzyme Molecule:
    MKP-1    		0.066666714explicit E-S complexMAPK-tyr
    		MAPK
    18 Enzyme Activity:
    phosph-AC2

    Enzyme Molecule:
    PKC-active    		33.333344explicit E-S complexAC2
    		AC2*
    19 Enzyme Activity:
    phosph-PDE

    Enzyme Molecule:
    PKA-active    		7.594explicit E-S complexcAMP-PDE
    		cAMP-PDE*
    20 Enzyme Activity:
    PKA-phosph-GEF

    Enzyme Molecule:
    PKA-active    		7.594explicit E-S complexinact-GEF
    		inact-GEF*
    21 Enzyme Activity:
    PKA-phosph-I1

    Enzyme Molecule:
    PKA-active    		7.594explicit E-S complexI1
    		I1*
    22 Enzyme Activity:
    PKC-act-GEF

    Enzyme Molecule:
    PKC-active    		3.3333344explicit E-S complexinact-GEF
    		GEF*
    23 Enzyme Activity:
    PKC-act-raf

    Enzyme Molecule:
    PKC-active    		66.666744explicit E-S complexcraf-1
    		craf-1*
    24 Enzyme Activity:
    PKC-inact-GAP

    Enzyme Molecule:
    PKC-active    		3.3333344explicit E-S complexGAP
    		GAP*
    25 Enzyme Activity:
    PKC-phosph-neuro
    granin

    Enzyme Molecule:
    PKC-active    		28.62750.584.03448explicit E-S complexneurogranin
    		neurogranin*
    26 Enzyme Activity:
    PKC-phosph-ng-Ca
    M

    Enzyme Molecule:
    PKC-active    		28.59480.354explicit E-S complexneurogranin-CaM
    		CaM
    neurogranin*
    27 Enzyme Activity:
    PP2A-dephosph-I1

    Enzyme Molecule:
    PP2A    		7.8282864.16667explicit E-S complexI1*
    		I1
    28 Enzyme Activity:
    PP2A-dephosph-PP
    1-I*

    Enzyme Molecule:
    PP2A    		7.8282864.16667explicit E-S complexPP1-I1*
    		PP1-I1


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