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Pathway Name Pathway No. | Accession Name Accession No. | Accession Type | Pathway statistics | sos statistics | Source Entry Date |
1 | Sos Pathway No. 9 | fig2_egfr
Accession No. 1 | Network | Molecule = 5 Enzyme = 0 Reaction = 4
| Molecule = 1 Enzyme = 0 Reaction = 0
| Bhalla US and Iyengar R. Science (1999) 283(5400):381-7. ( peer-reviewed publication )/ 2001-11-07 00:00:00 |
| #9Related Pathway: 33, 78, 180, 214, 233, 320, 337, 355 |
| This network was used to generate figure 2 in Bhalla US and Iyengar R. Science (1999) 283(5400):381-7. It consists of the MAPK cascade in a feedback loop with PKC, and receives input from the EGFR in the synapse. Demonstration script files for generating the figures in the paper, including figure 2, are available here. |
| This pathway is part of accession 1 and is completely specified in the file acc1.g. There is no separate files for just this pathway. |
Format | File | Native Format (GENESIS format) | acc1.g | GENESIS Format (Annotated version) | Anno_acc1.g |
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2 | Sos Pathway No. 33 | mkp1_feedback_ effects Accession No. 4 | Network | Molecule = 5 Enzyme = 0 Reaction = 4
| Molecule = 1 Enzyme = 0 Reaction = 0
| Bhalla US et al. Science (2002) 297(5583):1018-23. ( peer-reviewed publication )/ 2001-11-07 00:00:00 |
| #9Related Pathway: 9, 78, 180, 214, 233, 320, 337, 355 |
| This represents the mSos protein and the Grb2 adapter protein involved in Ras activation. This module provides for input from RTKs as well as feedback inhibition from MAPK, although the latter is not implemented in this specific model. |
| This pathway is part of accession 4 and is completely specified in the file acc4.g. There is no separate files for just this pathway. |
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3 | Sos Pathway No. 78 | Synaptic_ Network Accession No. 16 | Network | Molecule = 5 Enzyme = 0 Reaction = 4
| Molecule = 1 Enzyme = 0 Reaction = 0
| Bhalla US and Iyengar R. Science (1999) 283(5400):381-7. ( peer-reviewed publication )/ 2001-12-12 00:00:00 |
| #9Related Pathway: 9, 33, 180, 214, 233, 320, 337, 355 |
| This represents the mSos protein and the Grb2 adapter protein involved in Ras activation. This module provides for input from RTKs as well as feedback inhibition from MAPK, although the latter is not implemented in this specific model. |
| This pathway is part of accession 16 and is completely specified in the file acc16.g. There is no separate files for just this pathway. |
Format | File | Native Format (GENESIS format) | acc16.g | GENESIS Format (Annotated version) | Anno_acc16.g |
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4 | Sos Pathway No. 180 | MAPK-bistability -fig1c Accession No. 35 | Network | Molecule = 5 Enzyme = 0 Reaction = 4
| Molecule = 1 Enzyme = 0 Reaction = 0
| Bhalla US et al. Science (2002) 297(5583):1018-23 ( peer-reviewed publication )./ 2002-11-07 00:00:00 |
| #9Related Pathway: 9, 33, 78, 214, 233, 320, 337, 355 |
| This represents the mSos protein and the Grb2 adapter protein involved in Ras activation. This module provides for input from RTKs as well as feedback inhibition from MAPK, although the latter is not implemented in this specific model. |
| This pathway is part of accession 35 and is completely specified in the file acc35.g. There is no separate files for just this pathway. |
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5 | Sos Pathway No. 214 | MAPK_network_ 2003 Accession No. 50 | Network | Molecule = 5 Enzyme = 0 Reaction = 4
| Molecule = 1 Enzyme = 0 Reaction = 0
| Bhalla US Biophys J. 2004 Aug;87(2):745-53. ( peer-reviewed publication )/ 2003-04-28 00:00:00 |
| #9Related Pathway: 9, 33, 78, 180, 233, 320, 337, 355 |
| This is a network model of many pathways present at the neuronal synapse. The network has properties of temporal tuning as well as steady-state computational properties. In its default form the network is bistable.Bhalla US Biophys J. 2004 Aug;87(2):745-53 |
| This pathway is part of accession 50 and is completely specified in the file acc50.g. There is no separate files for just this pathway. |
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6 | Sos Pathway No. 233 | EGFR_MAPK
Accession No. 58 | Network | Molecule = 5 Enzyme = 0 Reaction = 4
| Molecule = 1 Enzyme = 0 Reaction = 0
| Bhalla US. Biophys J. (2004) 87(2):745-53. ( peer-reviewed publication )/ 2004-01-14 00:00:00 |
| #9Related Pathway: 9, 33, 78, 180, 214, 320, 337, 355 |
| Model of MAPK activation by EGFR in the synapse. Demonstration programs using this model are available here. Primary citation:Bhalla US. Biophys J. (2004) 87(2):745-53. |
| This pathway is part of accession 58 and is completely specified in the file acc58.g. There is no separate files for just this pathway. |
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7 | Sos Pathway No. 320 | Ajay_Bhalla_ 2004_PKM_Tuning Accession No. 76 | Network | Molecule = 5 Enzyme = 0 Reaction = 4
| Molecule = 1 Enzyme = 0 Reaction = 0
| Ajay SM, Bhalla US. Eur J Neurosci. 2004 Nov;20(10):2671-80. ( Peer-reviewed publication )/ 2006-12-12 00:00:00 |
| #9Related Pathway: 9, 33, 78, 180, 214, 233, 337, 355 |
| This model is taken from the Ajay SM, Bhalla US. Eur J Neurosci. 2004 Nov;20(10):2671-80. This is the reference feedforward model from Figure 8a. |
| This pathway is part of accession 76 and is completely specified in the file acc76.g. There is no separate files for just this pathway. |
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8 | Sos Pathway No. 337 | Ajay_Bhalla_ 2004_PKM_MKP3_ Tuning Accession No. 77 | Network | Molecule = 5 Enzyme = 0 Reaction = 4
| Molecule = 1 Enzyme = 0 Reaction = 0
| Ajay SM, Bhalla US. Eur J Neurosci. 2004 Nov;20(10):2671-80 ( Peer-reviewed publication )/ 2006-12-12 00:00:00 |
| #9Related Pathway: 9, 33, 78, 180, 214, 233, 320, 355 |
| This model is based on Ajay SM, Bhalla US. Eur J Neurosci. 2004 Nov;20(10):2671-80. This is the feedforward model with MPK3 from figure 8a. |
| This pathway is part of accession 77 and is completely specified in the file acc77.g. There is no separate files for just this pathway. |
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9 | Sos Pathway No. 355 | Ajay_Bhalla_ 2004_Feedback_ Tuning Accession No. 78 | Network | Molecule = 5 Enzyme = 0 Reaction = 4
| Molecule = 1 Enzyme = 0 Reaction = 0
| Ajay SM, Bhalla US. Eur J Neurosci. 2004 Nov;20(10):2671-80. ( Peer-reviewed publication )/ 2006-12-12 00:00:00 |
| #9Related Pathway: 9, 33, 78, 180, 214, 233, 320, 337 |
| This model is taken from Ajay SM, Bhalla US. Eur J Neurosci. 2004 Nov;20(10):2671-80. This is the feedback model from Figure 8a. |
| This pathway is part of accession 78 and is completely specified in the file acc78.g. There is no separate files for just this pathway. |
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