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Default ordering is done according to Pathway Name.Table header can be used for changing the default ordering. indicates that ordering is done according to ascending or descending order.Entries are color tagged depending on Network or Pathway ![]() |
| Pathway Name Pathway No. | Accession Name![]() Accession No. | Accession Type | Pathway statistics | sos statistics | Source Entry Date | ||||||||||||||
| 1 | Sos Pathway No. 78 | Synaptic_ Network Accession No. 16 | Network | Molecule = 5 Enzyme = 0 Reaction = 4 | Molecule = 1 Enzyme = 0 Reaction = 0 | Bhalla US and Iyengar R. Science (1999) 283(5400):381-7. ( peer-reviewed publication )/ 2001-12-12 00:00:00 | |||||||||||||
| Related Pathway: 9, 33, 180, 214, 233, 320, 337, 355, 1107 | |||||||||||||||||||
| This represents the mSos protein and the Grb2 adapter protein involved in Ras activation. This module provides for input from RTKs as well as feedback inhibition from MAPK, although the latter is not implemented in this specific model. | |||||||||||||||||||
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| 2 | Sos Pathway No. 1107 | mTOR_pathway Accession No. 92 | Network | Molecule = 4 Enzyme = 0 Reaction = 4 | Molecule = 1 Enzyme = 0 Reaction = 0 | Jain P, and Bhalla, U.S. PLoS Comput Biol. 2009 Feb;5(2). ( Peer-reviewed publication )/ 2009-02-13 00:00:00 | |||||||||||||
| Related Pathway: 9, 33, 78, 180, 214, 233, 320, 337, 355 | |||||||||||||||||||
| This model consists of various sub-modules. They are as follows: 1) BDNF receptor signaling 2) AKT signaling 3) 4E-BP model 4) S6 Kinase model 5) CaMKIII model 6) Protein synthesis model 7) CaM 8) PKC 9) MAPK model. | |||||||||||||||||||
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| 3 | Sos Pathway No. 33 | mkp1_feedback_ effects Accession No. 4 | Network | Molecule = 5 Enzyme = 0 Reaction = 4 | Molecule = 1 Enzyme = 0 Reaction = 0 | Bhalla US et al. Science (2002) 297(5583):1018-23. ( peer-reviewed publication )/ 2001-11-07 00:00:00 | |||||||||||||
| Related Pathway: 9, 78, 180, 214, 233, 320, 337, 355, 1107 | |||||||||||||||||||
| This represents the mSos protein and the Grb2 adapter protein involved in Ras activation. This module provides for input from RTKs as well as feedback inhibition from MAPK, although the latter is not implemented in this specific model. | |||||||||||||||||||
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| 4 | Sos Pathway No. 214 | MAPK_network_ 2003 Accession No. 50 | Network | Molecule = 5 Enzyme = 0 Reaction = 4 | Molecule = 1 Enzyme = 0 Reaction = 0 | Bhalla US Biophys J. 2004 Aug;87(2):745-53. ( peer-reviewed publication )/ 2003-04-28 00:00:00 | |||||||||||||
| Related Pathway: 9, 33, 78, 180, 233, 320, 337, 355, 1107 | |||||||||||||||||||
| This is a network model of many pathways present at the neuronal synapse. The network has properties of temporal tuning as well as steady-state computational properties. In its default form the network is bistable.Bhalla US Biophys J. 2004 Aug;87(2):745-53 | |||||||||||||||||||
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| 5 | Sos Pathway No. 180 | MAPK-bistability -fig1c Accession No. 35 | Network | Molecule = 5 Enzyme = 0 Reaction = 4 | Molecule = 1 Enzyme = 0 Reaction = 0 | Bhalla US et al. Science (2002) 297(5583):1018-23 ( peer-reviewed publication )./ 2002-11-07 00:00:00 | |||||||||||||
| Related Pathway: 9, 33, 78, 214, 233, 320, 337, 355, 1107 | |||||||||||||||||||
| This represents the mSos protein and the Grb2 adapter protein involved in Ras activation. This module provides for input from RTKs as well as feedback inhibition from MAPK, although the latter is not implemented in this specific model. | |||||||||||||||||||
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| 6 | Sos Pathway No. 9 | fig2_egfr Accession No. 1 | Network | Molecule = 5 Enzyme = 0 Reaction = 4 | Molecule = 1 Enzyme = 0 Reaction = 0 | Bhalla US and Iyengar R. Science (1999) 283(5400):381-7. ( peer-reviewed publication )/ 2001-11-07 00:00:00 | |||||||||||||
| Related Pathway: 33, 78, 180, 214, 233, 320, 337, 355, 1107 | |||||||||||||||||||
| This network was used to generate figure 2 in Bhalla US and Iyengar R. Science (1999) 283(5400):381-7. It consists of the MAPK cascade in a feedback loop with PKC, and receives input from the EGFR in the synapse. Demonstration script files for generating the figures in the paper, including figure 2, are available here. | |||||||||||||||||||
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| 7 | Sos Pathway No. 233 | EGFR_MAPK Accession No. 58 | Network | Molecule = 5 Enzyme = 0 Reaction = 4 | Molecule = 1 Enzyme = 0 Reaction = 0 | Bhalla US. Biophys J. (2004) 87(2):745-53. ( peer-reviewed publication )/ 2004-01-14 00:00:00 | |||||||||||||
| Related Pathway: 9, 33, 78, 180, 214, 320, 337, 355, 1107 | |||||||||||||||||||
| Model of MAPK activation by EGFR in the synapse. Demonstration programs using this model are available here. Primary citation:Bhalla US. Biophys J. (2004) 87(2):745-53. | |||||||||||||||||||
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| 8 | Sos Pathway No. 320 | Ajay_Bhalla_ 2004_PKM_Tuning Accession No. 76 | Network | Molecule = 5 Enzyme = 0 Reaction = 4 | Molecule = 1 Enzyme = 0 Reaction = 0 | Ajay SM, Bhalla US. Eur J Neurosci. 2004 Nov;20(10):2671-80. ( Peer-reviewed publication )/ 2006-12-12 00:00:00 | |||||||||||||
| Related Pathway: 9, 33, 78, 180, 214, 233, 337, 355, 1107 | |||||||||||||||||||
| This model is taken from the Ajay SM, Bhalla US. Eur J Neurosci. 2004 Nov;20(10):2671-80. This is the reference feedforward model from Figure 8a. | |||||||||||||||||||
| 9 | Sos Pathway No. 337 | Ajay_Bhalla_ 2004_PKM_MKP3_ Tuning Accession No. 77 | Network | Molecule = 5 Enzyme = 0 Reaction = 4 | Molecule = 1 Enzyme = 0 Reaction = 0 | Ajay SM, Bhalla US. Eur J Neurosci. 2004 Nov;20(10):2671-80 ( Peer-reviewed publication )/ 2006-12-12 00:00:00 | |||||||||||||
| Related Pathway: 9, 33, 78, 180, 214, 233, 320, 355, 1107 | |||||||||||||||||||
| This model is based on Ajay SM, Bhalla US. Eur J Neurosci. 2004 Nov;20(10):2671-80. This is the feedforward model with MPK3 from figure 8a. | |||||||||||||||||||
| 10 | Sos Pathway No. 355 | Ajay_Bhalla_ 2004_Feedback_ Tuning Accession No. 78 | Network | Molecule = 5 Enzyme = 0 Reaction = 4 | Molecule = 1 Enzyme = 0 Reaction = 0 | Ajay SM, Bhalla US. Eur J Neurosci. 2004 Nov;20(10):2671-80. ( Peer-reviewed publication )/ 2006-12-12 00:00:00 | |||||||||||||
| Related Pathway: 9, 33, 78, 180, 214, 233, 320, 337, 1107 | |||||||||||||||||||
| This model is taken from Ajay SM, Bhalla US. Eur J Neurosci. 2004 Nov;20(10):2671-80. This is the feedback model from Figure 8a. | |||||||||||||||||||
indicates that ordering is done according to ascending or descending order.
or Pathway 