NCBS Home page
Accession List
Pathway List
Search
Authorized Users
Help
News archives

Accession Type:
Network
Ajay_Bhalla_
2007_Bistable
Shared_Object_
Ajay_Bhalla_
2007_Bistable
PKC
PLA2
MAPK
 Molecule
 Enzyme
Ras
CaM

Enter a Search String

Special character and space not allowed in the query term. Search string should be at least 2 characters long.
Search in: Search for Match By

Parameters for MAPK (Pathway Number 366)

Pathway Layout

Pathway Basic Parameters

Pathway NameMAPK
Pathway Entry Number 366
Accession Number 79
Accession Name Ajay_Bhalla_2007_Bistable
Species Rat
Tissue Hippocampal CA1
CellCompartmentDendrite
Related Pathways 6, 24, 35, 56, 61, 75, 139, 142, 182, 193, 211, 230, 317, 335, 352, 371, 377, 384, 390, 396, 402, 403, 409, 415, 421, 432, 438, 444, 450, 456, 462, 468, 474, 480, 486, 492, 498, 504, 510, 516, 522, 528, 535, 541, 547, 553, 559, 565, 571, 577, 583, 589, 595, 601, 607, 613, 619, 625, 631, 637, 643, 649, 655, 661, 667, 673, 679, 686, 692, 699, 704, 710, 716, 722, 728, 734, 740, 746, 752, 758, 764, 770, 776, 782, 788, 794, 800, 806, 812, 818, 824, 830, 836, 842, 848, 854, 860, 866, 872, 878, 884, 890, 896, 902, 908, 914, 921, 928, 934, 940, 946, 952, 958, 960, 965, 971, 977, 983, 989, 995, 1006, 1012, 1018, 1024, 1030, 1036, 1042, 1048, 1054, 1060, 1066
Notes  This is a model of ERKII signaling which is bistable due to feedback. The feedback occurs through ERKII phosphorylation of phospholipase A2 (PLA2), leading to increased production of arachidonic acid (AA), which activates protein kinase C (PKC) which activates c-Raf which is upstream of ERKII.
The model is a highly simplified variant of more detailed bistable models of MAPK signaling (Bhalla US, Iyengar R. Science. 1999 Jan 15;283(5400):381-7, Ajay SM, Bhalla US. Eur J Neurosci. 2004 Nov;20(10):2671-80)

Statistics

Reactions
10
6
0

Conversion format

This pathway is part of accession 79 and is completely specified in the file acc79.g.
There is no separate files for just this pathway.
FormatFile
Native Format (GENESIS format)    acc79.g   
MATLAB format    acc79.m   
SBML format    acc79.xml   


Pathway Detail   Molecule List   Enzyme List  Reaction List  

Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
This Copyright is applied to ensure that the contents of this database remain freely available. Please see FAQ for details.