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Default ordering is done according to Pathway Name.Table header can be used for changing the default ordering. indicates that ordering is done according to ascending or descending order.Entries are color tagged depending on Network or Pathway ![]() |
Pathway Name![]() Pathway No. | Accession Name Accession No. | Accession Type | Pathway statistics | pla2 statistics | Source Entry Date | ||||||||||||||||
| 21 | PLA2 Pathway No. 21 | fig4_synapse Accession No. 3 | Network | Molecule = 8 Enzyme = 5 Reaction = 7 | Molecule = 0 Enzyme = 0 Reaction = 0 | Bhalla US and Iyengar R. Science (1999) 283(5400):381-7. ( peer-reviewed publication )/ 2001-11-07 00:00:00 | |||||||||||||||
| Related Pathway: 3, 36, 57, 62, 72, 183, 208, 314, 331, 349, 365, 920, 922, 933, 939, 945, 951, 957, 964, 970, 976, 982, 988, 994 1000, 1005, 1011, 1017, 1023, 1029, 1035, 1041, 1047, 1053, 1059, 1065 | |||||||||||||||||||||
| This is the composite model of 4 kinases: PKC, MAPK, PKA and CaMKII and numerous regulatory pathways involved in synaptic signaling. From Bhalla US and Iyengar R. Science (1999) 283(5400):381-7.This model comes from figure 4 of that paper. Demonstration script files for generating the figures in the paper, including figure 4, are available here. | |||||||||||||||||||||
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| 22 | PLA2 Pathway No. 36 | mkp1_feedback_ effects Accession No. 4 | Network | Molecule = 8 Enzyme = 5 Reaction = 7 | Molecule = 0 Enzyme = 0 Reaction = 0 | Bhalla US et al. Science (2002) 297(5583):1018-23. ( peer-reviewed publication )/ 2001-11-07 00:00:00 | |||||||||||||||
| Related Pathway: 3, 21, 57, 62, 72, 183, 208, 314, 331, 349, 365, 920, 922, 933, 939, 945, 951, 957, 964, 970, 976, 982, 988, 994 1000, 1005, 1011, 1017, 1023, 1029, 1035, 1041, 1047, 1053, 1059, 1065 | |||||||||||||||||||||
| Main source of data: Leslie and Channon BBA 1045 (1990) pp 261-270. Fig 6 is Ca curve. Fig 4a is PIP2 curve. Fig 4b is DAG curve. Also see Wijkander and Sundler JBC 202 (1991) pp873-880; Diez and Mong JBC 265(24) p14654; Leslie JBC 266(17) (1991) pp11366-11371 Many inputs activate PLA2. In this model I simply take each combination of stimuli as binding to PLA2 to give a unique enzymatic activity. The Km and Vmax of these active complexes is scaled according to the relative activation reported in the papers above. | |||||||||||||||||||||
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| 23 | PLA2 Pathway No. 57 | 3d_fold_model Accession No. 8 | Network | Molecule = 8 Enzyme = 5 Reaction = 7 | Molecule = 0 Enzyme = 0 Reaction = 0 | Bhalla US and Iyengar R. Science (1999) 283(5400):381-7. ( peer-reviewed publication )/ 2001-11-08 00:00:00 | |||||||||||||||
| Related Pathway: 3, 21, 36, 62, 72, 183, 208, 314, 331, 349, 365, 920, 922, 933, 939, 945, 951, 957, 964, 970, 976, 982, 988, 994 1000, 1005, 1011, 1017, 1023, 1029, 1035, 1041, 1047, 1053, 1059, 1065 | |||||||||||||||||||||
| Mail source of data: Leslie and Channon BBA 1045 (1990) pp 261-270. Fig 6 is Ca curve. Fig 4a is PIP2 curve. Fig 4b is DAG curve. Also see Wijkander and Sundler JBC 202 (1991) pp873-880; Diez and Mong JBC 265(24) p14654; Leslie JBC 266(17) (1991) pp11366-11371 | |||||||||||||||||||||
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| 24 | PLA2 Pathway No. 62 | MAPK_MKP1_ oscillation Accession No. 9 | Network | Molecule = 8 Enzyme = 5 Reaction = 7 | Molecule = 0 Enzyme = 0 Reaction = 0 | Bhalla US, Iyengar R. Chaos (2001) 11(1):221-226. ( peer-reviewed publication )/ 2001-11-08 00:00:00 | |||||||||||||||
| Related Pathway: 3, 21, 36, 57, 72, 183, 208, 314, 331, 349, 365, 920, 922, 933, 939, 945, 951, 957, 964, 970, 976, 982, 988, 994 1000, 1005, 1011, 1017, 1023, 1029, 1035, 1041, 1047, 1053, 1059, 1065 | |||||||||||||||||||||
| Mail source of data: Leslie and Channon BBA 1045 (1990) pp 261-270. Fig 6 is Ca curve. Fig 4a is PIP2 c urve. Fig 4b is DAG curve. Also see Wijkander and Sundler JBC 202 (1991) pp873-880; Diez and Mong JBC 265(24) p 14654; Leslie JBC 266(17) (1991) pp11366-11371 | |||||||||||||||||||||
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| 25 | PLA2 Pathway No. 72 | Synaptic_ Network Accession No. 16 | Network | Molecule = 8 Enzyme = 5 Reaction = 7 | Molecule = 0 Enzyme = 0 Reaction = 0 | Bhalla US and Iyengar R. Science (1999) 283(5400):381-7. ( peer-reviewed publication )/ 2001-12-12 00:00:00 | |||||||||||||||
| Related Pathway: 3, 21, 36, 57, 62, 183, 208, 314, 331, 349, 365, 920, 922, 933, 939, 945, 951, 957, 964, 970, 976, 982, 988, 994 1000, 1005, 1011, 1017, 1023, 1029, 1035, 1041, 1047, 1053, 1059, 1065 | |||||||||||||||||||||
| Main source of data: Leslie and Channon BBA 1045 (1990) pp 261-270. Fig 6 is Ca curve. Fig 4a is PIP2 curve. Fig 4b is DAG curve. Also see Wijkander and Sundler JBC 202 (1991) pp873-880; Diez and Mong JBC 265(24) p14654; Leslie JBC 266(17) (1991) pp11366-11371 Many inputs activate PLA2. In this model I simply take each combination of stimuli as binding to PLA2 to give a unique enzymatic activity. The Km and Vmax of these active complexes is scaled according to the relative activation reported in the papers above. | |||||||||||||||||||||
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| 26 | PLA2 Pathway No. 183 | MAPK-bistability -fig1c Accession No. 35 | Network | Molecule = 8 Enzyme = 5 Reaction = 7 | Molecule = 0 Enzyme = 0 Reaction = 0 | Bhalla US et al. Science (2002) 297(5583):1018-23 ( peer-reviewed publication )./ 2002-11-07 00:00:00 | |||||||||||||||
| Related Pathway: 3, 21, 36, 57, 62, 72, 208, 314, 331, 349, 365, 920, 922, 933, 939, 945, 951, 957, 964, 970, 976, 982, 988, 994, 1000 1005, 1011, 1017, 1023, 1029, 1035, 1041, 1047, 1053, 1059, 1065 | |||||||||||||||||||||
| Main source of data: Leslie and Channon BBA 1045 (1990) pp 261-270. Fig 6 is Ca curve. Fig 4a is PIP2 curve. Fig 4b is DAG curve. Also see Wijkander and Sundler JBC 202 (1991) pp873-880; Diez and Mong JBC 265(24) p14654; Leslie JBC 266(17) (1991) pp11366-11371 Many inputs activate PLA2. In this model I simply take each combination of stimuli as binding to PLA2 to give a unique enzymatic activity. The Km and Vmax of these active complexes is scaled according to the relative activation reported in the papers above. | |||||||||||||||||||||
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| 27 | PLA2 Pathway No. 208 | MAPK_network_ 2003 Accession No. 50 | Network | Molecule = 8 Enzyme = 5 Reaction = 7 | Molecule = 0 Enzyme = 0 Reaction = 0 | Bhalla US Biophys J. 2004 Aug;87(2):745-53. ( peer-reviewed publication )/ 2003-04-28 00:00:00 | |||||||||||||||
| Related Pathway: 3, 21, 36, 57, 62, 72, 183, 314, 331, 349, 365, 920, 922, 933, 939, 945, 951, 957, 964, 970, 976, 982, 988, 994, 1000 1005, 1011, 1017, 1023, 1029, 1035, 1041, 1047, 1053, 1059, 1065 | |||||||||||||||||||||
| Mail source of data: Leslie CC, Channon JY. Biochim Biophys Acta. 1990 Aug 6;1045(3):261-70. Fig 6 is Ca curve. Fig 4a is PIP2 curve. Fig 4b is DAG curve. Also see Wijkander J and Sundler R JBC 202 (1991) pp873-880; Diez and Mong JBC 265(24) p14654; Leslie CC J Biol Chem. 1991 Jun 15;266(17):11366-71. | |||||||||||||||||||||
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| 28 | PLA2 Pathway No. 314 | Ajay_Bhalla_ 2004_PKM_Tuning Accession No. 76 | Network | Molecule = 8 Enzyme = 5 Reaction = 7 | Molecule = 0 Enzyme = 0 Reaction = 0 | Ajay SM, Bhalla US. Eur J Neurosci. 2004 Nov;20(10):2671-80. ( Peer-reviewed publication )/ 2006-12-12 00:00:00 | |||||||||||||||
| Related Pathway: 3, 21, 36, 57, 62, 72, 183, 208, 331, 349, 365, 920, 922, 933, 939, 945, 951, 957, 964, 970, 976, 982, 988, 994, 1000 1005, 1011, 1017, 1023, 1029, 1035, 1041, 1047, 1053, 1059, 1065 | |||||||||||||||||||||
| Mail source of data: Leslie and Channon BBA 1045 (1990) pp 261-270. Fig 6 is Ca curve. Fig 4a is PIP2 curve. Fig 4b is DAG curve. Also see Wijkander and Sundler JBC 202 (1991) pp873-880; Diez and Mong JBC 265(24) p14654; Leslie JBC 266(17) (1991) pp11366-11371 | |||||||||||||||||||||
| 29 | PLA2 Pathway No. 3 | fig2_egfr Accession No. 1 | Network | Molecule = 8 Enzyme = 5 Reaction = 7 | Molecule = 0 Enzyme = 0 Reaction = 0 | Bhalla US and Iyengar R. Science (1999) 283(5400):381-7. ( peer-reviewed publication )/ 2001-11-07 00:00:00 | |||||||||||||||
| Related Pathway: 21, 36, 57, 62, 72, 183, 208, 314, 331, 349, 365, 920, 922, 933, 939, 945, 951, 957, 964, 970, 976, 982, 988, 994 1000, 1005, 1011, 1017, 1023, 1029, 1035, 1041, 1047, 1053, 1059, 1065 | |||||||||||||||||||||
| This network was used to generate figure 2 in Bhalla US and Iyengar R. Science (1999) 283(5400):381-7. It consists of the MAPK cascade in a feedback loop with PKC, and receives input from the EGFR in the synapse. Demonstration script files for generating the figures in the paper, including figure 2, are available here. | |||||||||||||||||||||
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| 30 | PLA2 Pathway No. 349 | Ajay_Bhalla_ 2004_Feedback_ Tuning Accession No. 78 | Network | Molecule = 8 Enzyme = 5 Reaction = 7 | Molecule = 0 Enzyme = 0 Reaction = 0 | Ajay SM, Bhalla US. Eur J Neurosci. 2004 Nov;20(10):2671-80. ( Peer-reviewed publication )/ 2006-12-12 00:00:00 | |||||||||||||||
| Related Pathway: 3, 21, 36, 57, 62, 72, 183, 208, 314, 331, 365, 920, 922, 933, 939, 945, 951, 957, 964, 970, 976, 982, 988, 994, 1000 1005, 1011, 1017, 1023, 1029, 1035, 1041, 1047, 1053, 1059, 1065 | |||||||||||||||||||||
| Mail source of data: Leslie and Channon BBA 1045 (1990) pp 261-270. Fig 6 is Ca curve. Fig 4a is PIP2 curve. Fig 4b is DAG curve. Also see Wijkander and Sundler JBC 202 (1991) pp873-880; Diez and Mong JBC 265(24) p14654; Leslie JBC 266(17) (1991) pp11366-11371 | |||||||||||||||||||||
| 31 | PLA2 Pathway No. 365 | Ajay_Bhalla_ 2007_Bistable Accession No. 79 | Network | Molecule = 8 Enzyme = 5 Reaction = 7 | Molecule = 0 Enzyme = 0 Reaction = 0 | Ajay_Bhalla_bistable_model. HFSP Journal. 2007 May;1(1):1-87/ 2006-12-08 00:00:00 | |||||||||||||||
| Related Pathway: 3, 21, 36, 57, 62, 72, 183, 208, 314, 331, 349, 920, 922, 933, 939, 945, 951, 957, 964, 970, 976, 982, 988, 994, 1000 1005, 1011, 1017, 1023, 1029, 1035, 1041, 1047, 1053, 1059, 1065 | |||||||||||||||||||||
| Mail source of data: Leslie and Channon BBA 1045 (1990) pp 261-270. Fig 6 is Ca curve. Fig 4a is PIP2 curve. Fig 4b is DAG curve. Also see Wijkander and Sundler JBC 202 (1991) pp873-880; Diez and Mong JBC 265(24) p14654; Leslie JBC 266(17) (1991) pp11366-11371 | |||||||||||||||||||||
| 32 | PLA2 Pathway No. 920 | Ajay_Bhalla_ 2007_ReacDiff3 Accession No. 84 | Network | Molecule = 8 Enzyme = 5 Reaction = 7 | Molecule = 0 Enzyme = 0 Reaction = 0 | Ajay_Bhalla_bistable_model. HFSP Journal. 2007 May;1(1):1-87/ 2006-12-08 00:00:00 | |||||||||||||||
| Related Pathway: 3, 21, 36, 57, 62, 72, 183, 208, 314, 331, 349, 365, 922, 933, 939, 945, 951, 957, 964, 970, 976, 982, 988, 994, 1000 1005, 1011, 1017, 1023, 1029, 1035, 1041, 1047, 1053, 1059, 1065 | |||||||||||||||||||||
| Mail source of data: Leslie and Channon BBA 1045 (1990) pp 261-270. Fig 6 is Ca curve. Fig 4a is PIP2 curve. Fig 4b is DAG curve. Also see Wijkander and Sundler JBC 202 (1991) pp873-880; Diez and Mong JBC 265(24) p14654; Leslie JBC 266(17) (1991) pp11366-11371 | |||||||||||||||||||||
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| 33 | PLA2 Pathway No. 922 | Ajay_Bhalla_ 2007_ReacDiff3 Accession No. 84 | Network | Molecule = 8 Enzyme = 5 Reaction = 7 | Molecule = 0 Enzyme = 0 Reaction = 0 | Ajay_Bhalla_bistable_model. HFSP Journal. 2007 May;1(1):1-87/ 2006-12-08 00:00:00 | |||||||||||||||
| Related Pathway: 3, 21, 36, 57, 62, 72, 183, 208, 314, 331, 349, 365, 920, 933, 939, 945, 951, 957, 964, 970, 976, 982, 988, 994, 1000 1005, 1011, 1017, 1023, 1029, 1035, 1041, 1047, 1053, 1059, 1065 | |||||||||||||||||||||
| Mail source of data: Leslie and Channon BBA 1045 (1990) pp 261-270. Fig 6 is Ca curve. Fig 4a is PIP2 curve. Fig 4b is DAG curve. Also see Wijkander and Sundler JBC 202 (1991) pp873-880; Diez and Mong JBC 265(24) p14654; Leslie JBC 266(17) (1991) pp11366-11371 | |||||||||||||||||||||
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| 34 | PLA2 Pathway No. 933 | Ajay_Bhalla_ 2007_ReacDiff3 Accession No. 84 | Network | Molecule = 8 Enzyme = 5 Reaction = 7 | Molecule = 0 Enzyme = 0 Reaction = 0 | Ajay_Bhalla_bistable_model. HFSP Journal. 2007 May;1(1):1-87/ 2006-12-08 00:00:00 | |||||||||||||||
| Related Pathway: 3, 21, 36, 57, 62, 72, 183, 208, 314, 331, 349, 365, 920, 922, 939, 945, 951, 957, 964, 970, 976, 982, 988, 994, 1000 1005, 1011, 1017, 1023, 1029, 1035, 1041, 1047, 1053, 1059, 1065 | |||||||||||||||||||||
| Mail source of data: Leslie and Channon BBA 1045 (1990) pp 261-270. Fig 6 is Ca curve. Fig 4a is PIP2 curve. Fig 4b is DAG curve. Also see Wijkander and Sundler JBC 202 (1991) pp873-880; Diez and Mong JBC 265(24) p14654; Leslie JBC 266(17) (1991) pp11366-11371 | |||||||||||||||||||||
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| 35 | PLA2 Pathway No. 939 | Ajay_Bhalla_ 2007_ReacDiff3 Accession No. 84 | Network | Molecule = 8 Enzyme = 5 Reaction = 7 | Molecule = 0 Enzyme = 0 Reaction = 0 | Ajay_Bhalla_bistable_model. HFSP Journal. 2007 May;1(1):1-87/ 2006-12-08 00:00:00 | |||||||||||||||
| Related Pathway: 3, 21, 36, 57, 62, 72, 183, 208, 314, 331, 349, 365, 920, 922, 933, 945, 951, 957, 964, 970, 976, 982, 988, 994, 1000 1005, 1011, 1017, 1023, 1029, 1035, 1041, 1047, 1053, 1059, 1065 | |||||||||||||||||||||
| Mail source of data: Leslie and Channon BBA 1045 (1990) pp 261-270. Fig 6 is Ca curve. Fig 4a is PIP2 curve. Fig 4b is DAG curve. Also see Wijkander and Sundler JBC 202 (1991) pp873-880; Diez and Mong JBC 265(24) p14654; Leslie JBC 266(17) (1991) pp11366-11371 | |||||||||||||||||||||
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| 36 | PLA2 Pathway No. 945 | Ajay_Bhalla_ 2007_ReacDiff3 Accession No. 84 | Network | Molecule = 8 Enzyme = 5 Reaction = 7 | Molecule = 0 Enzyme = 0 Reaction = 0 | Ajay_Bhalla_bistable_model. HFSP Journal. 2007 May;1(1):1-87/ 2006-12-08 00:00:00 | |||||||||||||||
| Related Pathway: 3, 21, 36, 57, 62, 72, 183, 208, 314, 331, 349, 365, 920, 922, 933, 939, 951, 957, 964, 970, 976, 982, 988, 994, 1000 1005, 1011, 1017, 1023, 1029, 1035, 1041, 1047, 1053, 1059, 1065 | |||||||||||||||||||||
| Mail source of data: Leslie and Channon BBA 1045 (1990) pp 261-270. Fig 6 is Ca curve. Fig 4a is PIP2 curve. Fig 4b is DAG curve. Also see Wijkander and Sundler JBC 202 (1991) pp873-880; Diez and Mong JBC 265(24) p14654; Leslie JBC 266(17) (1991) pp11366-11371 | |||||||||||||||||||||
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| 37 | PLA2 Pathway No. 951 | Ajay_Bhalla_ 2007_ReacDiff3 Accession No. 84 | Network | Molecule = 8 Enzyme = 5 Reaction = 7 | Molecule = 0 Enzyme = 0 Reaction = 0 | Ajay_Bhalla_bistable_model. HFSP Journal. 2007 May;1(1):1-87/ 2006-12-08 00:00:00 | |||||||||||||||
| Related Pathway: 3, 21, 36, 57, 62, 72, 183, 208, 314, 331, 349, 365, 920, 922, 933, 939, 945, 957, 964, 970, 976, 982, 988, 994, 1000 1005, 1011, 1017, 1023, 1029, 1035, 1041, 1047, 1053, 1059, 1065 | |||||||||||||||||||||
| Mail source of data: Leslie and Channon BBA 1045 (1990) pp 261-270. Fig 6 is Ca curve. Fig 4a is PIP2 curve. Fig 4b is DAG curve. Also see Wijkander and Sundler JBC 202 (1991) pp873-880; Diez and Mong JBC 265(24) p14654; Leslie JBC 266(17) (1991) pp11366-11371 | |||||||||||||||||||||
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indicates that ordering is done according to ascending or descending order.
or Pathway 