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Result: 21 - 34 of 34 rows are displayed Previous of 2  Next

Pathway List for CamKII

Default ordering is done according to Pathway Name.Table header can be used for changing the default ordering.
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Entries are color tagged depending on Network  or Pathway 
#19#19#1#19#19#19#1#19#1#19#1#19#1#1
  Pathway Name
Pathway No.		Accession Name
Accession No.		Accession
Type		Pathway statisticsCamKII statisticsSource
Entry Date
21 CaMKII
Pathway No. 145		 NonOsc_Ca_
IP3metabolism
Accession No. 31		NetworkMolecule = 10
Enzyme   = 13
Reaction  = 3
Molecule = 8
Enzyme   = 8
Reaction  = 1
 Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316. ( peer-reviewed publication )/
2002-04-03 00:00:00
   Related Pathway: 
13, 26, 80, 106, 121, 159, 174, 202, 216, 235, 245, 258, 264, 272, 282, 322, 339, 357
    Main reference here is the review by Hanson and Schulman, Ann Rev Biochem 1992 vol 61 pp 559-601. Most of the mechanistic details and a few constants are derived from there. Many kinetics are from Hanson and Schulman JBC 267:24 17216-17224 1992. The enzymes look a bit complicated. Actually it is just 3 reactions for different sites, by 4 states of CaMKII, defined by the phosphorylation state. This model approximates the fact that the enzyme is actually present as a decamer/dodecamer. It does so by treating the autophosphorylation reactions as being independent of the concentration of CaMKII. Also the rates for the autophosphorylation steps have been scaled to fit this approximation.
   
This pathway is part of accession 31 and is completely specified in the file acc31.g.
There is no separate files for just this pathway.
FormatFile
Native Format (GENESIS format)    acc31.g   
GENESIS Format (Annotated version)    Anno_acc31.g   
22 CaMKII
Pathway No. 159		 Osc_Ca_
IP3metabolism
Accession No. 32		NetworkMolecule = 10
Enzyme   = 13
Reaction  = 3
Molecule = 8
Enzyme   = 8
Reaction  = 1
 Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316. ( peer-reviewed publication )/
2002-04-03 00:00:00
   Related Pathway: 
13, 26, 80, 106, 121, 145, 174, 202, 216, 235, 245, 258, 264, 272, 282, 322, 339, 357
    Main reference here is the review by Hanson and Schulman, Ann Rev Biochem 1992 vol 61 pp 559-601. Most of the mechanistic details and a few constants are derived from there. Many kinetics are from Hanson and Schulman JBC 267:24 17216-17224 1992. The enzymes look a bit complicated. Actually it is just 3 reactions for different sites, by 4 states of CaMKII, defined by the phosphorylation state. This model approximates the fact that the enzyme is actually present as a decamer/dodecamer. It does so by treating the autophosphorylation reactions as being independent of the concentration of CaMKII. Also the rates for the autophosphorylation steps have been scaled to fit this approximation.
   
This pathway is part of accession 32 and is completely specified in the file acc32.g.
There is no separate files for just this pathway.
FormatFile
Native Format (GENESIS format)    acc32.g   
GENESIS Format (Annotated version)    Anno_acc32.g   
23 
  • Shared_Object_
    CaMKII_noPKA_
    model3
    Pathway No. 257
    		•  CaMKII_noPKA_
    model3
    Accession No. 62    		NetworkMolecule = 33
    Enzyme   = 28
    Reaction  = 13
    		Molecule = 14
    Enzyme   = 3
    Reaction  = 4
    		Hayer A, Bhalla US PLoS PLoS Comput Biol. 2005 Jul;1(2):137-54. Epub 2005 Jul 29. ( Peer-reviewed publication )/
    2005-07-19 00:00:00
       Related Pathway: ------
        This is the model of CaMKII bistability, model 3. It exhibits bistability in CaMKII activation due to autophosphorylation at the PSD and local saturation of PP1. This version of model 3 does not include the full PKA regulatory pathway, and instead has a predefined initial amount of active PKA.
       
    This pathway is part of accession 62 and is completely specified in the file acc62.g.
    There is no separate files for just this pathway.
    FormatFile
    Native Format (GENESIS format)    acc62.g   
    MATLAB format    acc62.m   
    SBML format    acc62.xml   
    24 CaMKII
    Pathway No. 258    		 CaMKII_noPKA_
    model3
    Accession No. 62    		NetworkMolecule = 8
    Enzyme   = 4
    Reaction  = 2
    		Molecule = 7
    Enzyme   = 4
    Reaction  = 1
    		Hayer A, Bhalla US PLoS PLoS Comput Biol. 2005 Jul;1(2):137-54. Epub 2005 Jul 29. ( Peer-reviewed publication )/
    2005-07-19 00:00:00
       Related Pathway: 
    13, 26, 80, 106, 121, 145, 159, 174, 202, 216, 235, 245, 264, 272, 282, 322, 339, 357
        Main reference here is the review by Hanson and Schulman, Ann Rev Biochem 1992 vol 61 pp 559-601. Most of the mechanistic details and a few constants are derived from there. Many kinetics are from Hanson and Schulman JBC 267:24 17216-17224 1992. The enzs look a terrible mess. Actually it is just 3 reactions for diff sites, by 4 states of CaMKII, defined by the phosph state.
       
    This pathway is part of accession 62 and is completely specified in the file acc62.g.
    There is no separate files for just this pathway.
    FormatFile
    Native Format (GENESIS format)    acc62.g   
    MATLAB format    acc62.m   
    SBML format    acc62.xml   
    25 CaMKII
    Pathway No. 235    		 AMPAR_traff_
    model0
    Accession No. 59    		NetworkMolecule = 25
    Enzyme   = 24
    Reaction  = 10
    		Molecule = 21
    Enzyme   = 22
    Reaction  = 5
    		Hayer A, Bhalla US PLoS Comput Biol. 2005 Jul;1(2):137-54. Epub 2005 Jul 29. ( Peer-reviewed publication )/
    2005-07-19 00:00:00
       Related Pathway: 
    13, 26, 80, 106, 121, 145, 159, 174, 202, 216, 245, 258, 264, 272, 282, 322, 339, 357
        Main reference here is the review by Hanson and Schulman, Ann Rev Biochem 1992 vol 61 pp 559-601. Most of the mechanistic details and a few constants are derived from there. Many kinetics are from Hanson and Schulman JBC 267:24 17216-17224 1992. The enzs look a terrible mess. Actually it is just 3 reactions for diff sites, by 4 states of CaMKII, defined by the phosph state.
       
    This pathway is part of accession 59 and is completely specified in the file acc59.g.
    There is no separate files for just this pathway.
    FormatFile
    Native Format (GENESIS format)    acc59.g   
    MATLAB format    acc59.m   
    SBML format    acc59.xml   
    26 CaMKII
    Pathway No. 245    		 AMPAR_traff_
    model1
    Accession No. 60    		NetworkMolecule = 25
    Enzyme   = 24
    Reaction  = 10
    		Molecule = 21
    Enzyme   = 22
    Reaction  = 5
    		Hayer A, Bhalla US PLoS Comput Biol. 2005 Jul;1(2):137-54. Epub 2005 Jul 29. ( Peer-reviewed publication )/
    2005-07-19 00:00:00
       Related Pathway: 
    13, 26, 80, 106, 121, 145, 159, 174, 202, 216, 235, 258, 264, 272, 282, 322, 339, 357
        Main reference here is the review by Hanson and Schulman, Ann Rev Biochem 1992 vol 61 pp 559-601. Most of the mechanistic details and a few constants are derived from there. Many kinetics are from Hanson and Schulman JBC 267:24 17216-17224 1992. The enzs look a terrible mess. Actually it is just 3 reactions for diff sites, by 4 states of CaMKII, defined by the phosph state.
       
    This pathway is part of accession 60 and is completely specified in the file acc60.g.
    There is no separate files for just this pathway.
    FormatFile
    Native Format (GENESIS format)    acc60.g   
    MATLAB format    acc60.m   
    SBML format    acc60.xml   
    27 
  • Shared_Object_
    CaMKII_model3
    Pathway No. 263
    		•  CaMKII_model3

    Accession No. 63    		NetworkMolecule = 36
    Enzyme   = 30
    Reaction  = 14
    		Molecule = 14
    Enzyme   = 3
    Reaction  = 4
    		Hayer A, Bhalla US PLoS Comput Biol. 2005 Jul;1(2):137-54. Epub 2005 Jul 29. ( Peer-reviewed publication )/
    2005-07-19 00:00:00
       Related Pathway: ------
        This is the complete model of CaMKII bistability, model 3. It exhibits bistability in CaMKII activation due to autophosphorylation at the PSD and local saturation of PP1. This version of model 3 includes PKA regulatory input. This has little effect on the deterministic calculations, but the PKA pathway introduces a lot of noise which causes a difference in stochastic runs.
       
    This pathway is part of accession 63 and is completely specified in the file acc63.g.
    There is no separate files for just this pathway.
    FormatFile
    Native Format (GENESIS format)    acc63.g   
    MATLAB format    acc63.m   
    SBML format    acc63.xml   
    28 CaMKII
    Pathway No. 264    		 CaMKII_model3

    Accession No. 63    		NetworkMolecule = 8
    Enzyme   = 4
    Reaction  = 2
    		Molecule = 7
    Enzyme   = 4
    Reaction  = 1
    		Hayer A, Bhalla US PLoS Comput Biol. 2005 Jul;1(2):137-54. Epub 2005 Jul 29. ( Peer-reviewed publication )/
    2005-07-19 00:00:00
       Related Pathway: 
    13, 26, 80, 106, 121, 145, 159, 174, 202, 216, 235, 245, 258, 272, 282, 322, 339, 357
        Main reference here is the review by Hanson and Schulman, Ann Rev Biochem 1992 vol 61 pp 559-601. Most of the mechanistic details and a few constants are derived from there. Many kinetics are from Hanson and Schulman JBC 267:24 17216-17224 1992. The enzs look a terrible mess. Actually it is just 3 reactions for diff sites, by 4 states of CaMKII, defined by the phosph state.
       
    This pathway is part of accession 63 and is completely specified in the file acc63.g.
    There is no separate files for just this pathway.
    FormatFile
    Native Format (GENESIS format)    acc63.g   
    MATLAB format    acc63.m   
    SBML format    acc63.xml   
    29 
  • Shared_Object_
    AMPAR_CaMKII_
    strong_coupling
    Pathway No. 271
    		•  AMPAR_CaMKII_
    strong_coupling
    Accession No. 64    		NetworkMolecule = 51
    Enzyme   = 148
    Reaction  = 16
    		Molecule = 14
    Enzyme   = 19
    Reaction  = 4
    		Hayer A, Bhalla US PLoS Comput Biol. 2005 Jul;1(2):137-54. Epub 2005 Jul 29. ( Peer-reviewed publication )/
    2005-07-19 00:00:00
       Related Pathway: ------
        This is a model of tight coupling between the AMPAR trafficking bistability, and the CaMKII autophosphorylation bistability. In this model, the CaMKII activity is self sustaining only when AMPAR is turned on. Further, CaMKII turns on when AMPAR is turned on.
       
    This pathway is part of accession 64 and is completely specified in the file acc64.g.
    There is no separate files for just this pathway.
    FormatFile
    Native Format (GENESIS format)    acc64.g   
    MATLAB format    acc64.m   
    SBML format    acc64.xml   
    30 CaMKII
    Pathway No. 272    		 AMPAR_CaMKII_
    strong_coupling
    Accession No. 64    		NetworkMolecule = 8
    Enzyme   = 4
    Reaction  = 2
    		Molecule = 7
    Enzyme   = 4
    Reaction  = 1
    		Hayer A, Bhalla US PLoS Comput Biol. 2005 Jul;1(2):137-54. Epub 2005 Jul 29. ( Peer-reviewed publication )/
    2005-07-19 00:00:00
       Related Pathway: 
    13, 26, 80, 106, 121, 145, 159, 174, 202, 216, 235, 245, 258, 264, 282, 322, 339, 357
        Main reference here is the review by Hanson and Schulman, Ann Rev Biochem 1992 vol 61 pp 559-601. Most of the mechanistic details and a few constants are derived from there. Many kinetics are from Hanson and Schulman JBC 267:24 17216-17224 1992. The enzs look a terrible mess. Actually it is just 3 reactions for diff sites, by 4 states of CaMKII, defined by the phosph state.
       
    This pathway is part of accession 64 and is completely specified in the file acc64.g.
    There is no separate files for just this pathway.
    FormatFile
    Native Format (GENESIS format)    acc64.g   
    MATLAB format    acc64.m   
    SBML format    acc64.xml   
    31 
  • Shared_Object_
    AMPAR_CaMKII_
    weak_coupling
    Pathway No. 281
    		•  AMPAR_CaMKII_
    weak_coupling
    Accession No. 65    		NetworkMolecule = 30
    Enzyme   = 14
    Reaction  = 8
    		Molecule = 0
    Enzyme   = 0
    Reaction  = 0
    		Hayer A, Bhalla US PLoS Comput Biol. 2005 Jul;1(2):137-54. Epub 2005 Jul 29. ( Peer-reviewed publication )/
    2005-07-21 00:00:00
       Related Pathway: ------
        This is a model of weak coupling between the AMPAR traffikcing bistability, and the CaMKII autophosphorylation bistability. In this model, there are three stable states: Both off, AMPAR on, or both on. The fourth possible state: CaMKII on but AMPAR off, is not truly stable, since over the course of hours the AMPAR also turns on.
       
    This pathway is part of accession 65 and is completely specified in the file acc65.g.
    There is no separate files for just this pathway.
    FormatFile
    Native Format (GENESIS format)    acc65.g   
    MATLAB format    acc65.m   
    SBML format    acc65.xml   
    32 CaMKII
    Pathway No. 282    		 AMPAR_CaMKII_
    weak_coupling
    Accession No. 65    		NetworkMolecule = 11
    Enzyme   = 4
    Reaction  = 2
    		Molecule = 10
    Enzyme   = 4
    Reaction  = 1
    		Hayer A, Bhalla US PLoS Comput Biol. 2005 Jul;1(2):137-54. Epub 2005 Jul 29. ( Peer-reviewed publication )/
    2005-07-21 00:00:00
       Related Pathway: 
    13, 26, 80, 106, 121, 145, 159, 174, 202, 216, 235, 245, 258, 264, 272, 322, 339, 357
        Main reference here is the review by Hanson and Schulman, Ann Rev Biochem 1992 vol 61 pp 559-601. Most of the mechanistic details and a few constants are derived from there. Many kinetics are from Hanson and Schulman JBC 267:24 17216-17224 1992. The enzs look a terrible mess. Actually it is just 3 reactions for diff sites, by 4 states of CaMKII, defined by the phosph state.
       
    This pathway is part of accession 65 and is completely specified in the file acc65.g.
    There is no separate files for just this pathway.
    FormatFile
    Native Format (GENESIS format)    acc65.g   
    MATLAB format    acc65.m   
    SBML format    acc65.xml   
    33 PP1_CaMKII_PSD
    Pathway No. 291    		 AMPAR_CaMKII_
    weak_coupling
    Accession No. 65    		NetworkMolecule = 1
    Enzyme   = 5
    Reaction  = 0
    		Molecule = 1
    Enzyme   = 5
    Reaction  = 0
    		Hayer A, Bhalla US PLoS Comput Biol. 2005 Jul;1(2):137-54. Epub 2005 Jul 29. ( Peer-reviewed publication )/
    2005-07-21 00:00:00
       Related Pathway: ------
        This is a model of weak coupling between the AMPAR traffikcing bistability, and the CaMKII autophosphorylation bistability. In this model, there are three stable states: Both off, AMPAR on, or both on. The fourth possible state: CaMKII on but AMPAR off, is not truly stable, since over the course of hours the AMPAR also turns on.
       
    This pathway is part of accession 65 and is completely specified in the file acc65.g.
    There is no separate files for just this pathway.
    FormatFile
    Native Format (GENESIS format)    acc65.g   
    MATLAB format    acc65.m   
    SBML format    acc65.xml   
    34 CaMKII_PSD
    Pathway No. 292    		 AMPAR_CaMKII_
    weak_coupling
    Accession No. 65    		NetworkMolecule = 14
    Enzyme   = 22
    Reaction  = 8
    		Molecule = 11
    Enzyme   = 19
    Reaction  = 4
    		Hayer A, Bhalla US PLoS Comput Biol. 2005 Jul;1(2):137-54. Epub 2005 Jul 29. ( Peer-reviewed publication )/
    2005-07-21 00:00:00
       Related Pathway: ------
        This is a model of weak coupling between the AMPAR traffikcing bistability, and the CaMKII autophosphorylation bistability. In this model, there are three stable states: Both off, AMPAR on, or both on. The fourth possible state: CaMKII on but AMPAR off, is not truly stable, since over the course of hours the AMPAR also turns on.
       
    This pathway is part of accession 65 and is completely specified in the file acc65.g.
    There is no separate files for just this pathway.
    FormatFile
    Native Format (GENESIS format)    acc65.g   
    MATLAB format    acc65.m   
    SBML format    acc65.xml   
     
    Result: 21 - 34 of 34 rows are displayed Previous of 2  Next


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