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Accession
No.
NameSource /
Entry Date
Species /
Tissue
Cell CompartmentMethodology /
Model Implementation
52
  • EGFR_Signaling_
    pathway
  • Quantification of Short Term Signaling by the EGFR Kholodenko et al, The J Biol Chem. , Vol 274, No. 42, Issue of October 15, pp. 30169 - 30181, 1999. ( peer-reviewed publication ) /
     2003-05-17 00:00:00
    Harlan Sprague Dawley rat; mammalian /
    Hepatocytes
    Cell membrane + cytosolQualitative /
    Mathematically equivalent
    97excBhalla US.PLoS Comput Biol 2021 Nov 29;17(11):e1009621. /
     2022-09-30 15:13:55
    Generic /
    cytosolFit to elementary ODE model /
    HillTau implementation
    98exc2ndOrderBhalla US.PLoS Comput Biol 2021 Nov 29;17(11):e1009621. /
     2022-09-30 17:52:22
    Generic /
    cytosolFit to elementary ODE model /
    HillTau implementation
    101
  • exc_tau_
    baseline
  • Bhalla US.PLoS Comput Biol 2021 Nov 29;17(11):e1009621. /
     2022-09-30 22:10:56
    Generic /
    cytosolFit to elementary ODE model /
    HillTau implementation
    104fb_inhibBhalla US.PLoS Comput Biol 2021 Nov 29;17(11):e1009621. /
     2022-09-30 22:16:21
    Generic /
    cytosolAbstract phenomenological model /
    HillTau implementation
    1fig2_egfrBhalla US and Iyengar R. Science (1999) 283(5400):381-7. ( peer-reviewed publication ) /
     2001-11-07 00:00:00
    Generic mammalian /
    Brain
    Surface - NucleusQuantitative match to experiments, Hypothetical /
    Exact GENESIS implementation
    2fig3_CaMKIIBhalla US and Iyengar R. Science (1999) 283(5400):381-7. ( peer-reviewed publication ) /
     2001-11-07 00:00:00
    Generic mammalian /
    Neuronal
    SynapseQuantitative match to experiments, Qualitative /
    Exact GENESIS implementation
    3fig4_synapseBhalla US and Iyengar R. Science (1999) 283(5400):381-7. ( peer-reviewed publication ) /
     2001-11-07 00:00:00
    Generic mammalian /
    Neuronal
    SynapseQuantitative match to experiments, Qualitative, Hypothetical /
    Exact GENESIS implementation
    103gainBhalla US.PLoS Comput Biol 2021 Nov 29;17(11):e1009621. /
     2022-09-30 22:14:44
    Generic /
    cytosolFit to elementary ODE model /
    HillTau implementation
    73HomoArginineAbu-Soud HM et al. Biochemistry. 1999 Sep 21;38(38):12446-51. ( Peer-reviewed publication ) /
     2006-08-07 00:00:00
    human /
    Kidney cell expressing the rat brain nNOS
    CytosolQuantitative match to experiments /
    Exact GENESIS implementation
    30
  • Huang_Ferrell_
    MAPK
  • Huang CY and Ferrell JE Jr. Proc Natl Acad Sci U S A. (1996) 93(19):10078-83 ( peer-reviewed publication ) /
     2002-01-31 00:00:00
    Xenopus /
    Oocytes extract
    CytosolQuantitative match to experiments /
    Approximate implementation
    100inhBhalla US.PLoS Comput Biol 2021 Nov 29;17(11):e1009621. /
     2022-09-30 22:08:48
    Generic /
    cytosolFit to elementary ODE model /
    HillTau implementation
    66
  • Jak-Stat_
    Pathway
  • Yamada S et al. FEBS Letters 2003 Jan 16;534(1-3):190-6. ( Peer-reviewed publication ) /
     2006-02-13 00:00:00
    mouse /
    Liver
    Cytosol, NucleusQuantitative match to experiments /
    Exact GENESIS implementation
    105kholodenkoBhalla US.PLoS Comput Biol 2021 Nov 29;17(11):e1009621. /
     2022-09-30 22:18:08
    Xenopus /
    Oocyte extract
    cytosolFit to ODE model and experiments /
    HillTau implementation
    29Kierzek_LacZKierzek AM. et al. J Biol Chem. (2001) 276(11):8165-72. ( peer-reviewed publication ) /
     2002-01-28 00:00:00
    E. Coli /
    -
    InternalQualitative /
    Approximate implementation
    18Kuroda_GCKuroda S. et al. J Neurosci. (2001) 21(15):5693-702. ( peer-reviewed publication ) /
     2001-12-24 00:00:00
    Generic mammalian /
    Neuronal
    SynapseQuantitative match to experiments /
    Exact GENESIS implementation
    72L-ArginineAbu-Soud HM et al. Biochemistry. 1999 Sep 21;38(38):12446-51. ( Peer-reviewed publication ) /
     2006-08-07 00:00:00
    Human /
    Kidney cell expressing the rat brain nNOS
    CytosolQuantitative match to experiments /
    Exact GENESIS implementation
    36luciferaseL. Yu. Brovko et al 1994, Biochemistry (Moscow) 59(2):195-201, 1994 ( peer-reviewed publication ). /
     2002-12-12 00:00:00
    E. Coli /
    -
    CytosolQualitative /
    Approximate implementation
    85
  • Mammalian_cell_
    cycle
  • Novak B,Tyson JJ. J Theor Biol. 2004 Oct 21;230(4):563-79. ( Peer-reviewed publication ) /
     2006-12-21 00:00:00
    General Mammalian /
    -
    NucleusQuantitative match to experiments /
    Approximate implementation
    35
  • MAPK-bistability
    -fig1c
  • Bhalla US et al. Science (2002) 297(5583):1018-23 ( peer-reviewed publication ). /
     2002-11-07 00:00:00
    Generic mammalian /
    NIH 3T3 Expression
    Surface - NucleusQuantitative match to experiments, Qualitative /
    Exact GENESIS implementation
    45
  • MAPK_Asthagiri_
    adapt_fb
  • Asthagiri AR and Lauffenburger DA. Biotechnol Prog. (2001) 17(2):227-39. ( peer-reviewed publication ). /
     2003-02-22 00:00:00
    Chinese hamster (Cricetulus griseus); mammalian /
    Ovary - CHO cell line
    Surface, cytosolQuantitative match to experiments, Qualitative /
    Mathematically equivalent
    46
  • MAPK_Asthagiri_
    enz_fb
  • Asthagiri AR and Lauffenburger DA. Biotechnol Prog. (2001) 17(2):227-39. ( peer-reviewed publication ). /
     2003-02-22 00:00:00
    Chinese hamster (Cricetulus griseus); mammalian /
    Ovary - CHO cell line
    Surface + cytosolQualitative /
    Approximate implementation
    44
  • MAPK_Asthagiri_
    no_fb
  • Asthagiri AR and Lauffenburger DA. Biotechnol Prog. (2001) 17(2):227-39. ( peer-reviewed publication ). /
     2003-02-22 00:00:00
    Chinese hamster (Cricetulus griseus); mammalian /
    Ovary - CHO cell line
    Surface, cytosolQuantitative match to experiments, Qualitative /
    Mathematically equivalent
    9
  • MAPK_MKP1_
    oscillation
  • Bhalla US, Iyengar R. Chaos (2001) 11(1):221-226. ( peer-reviewed publication ) /
     2001-11-08 00:00:00
    Generic mammalian /
    NIH 3T3 Expression
    Surface - NucleusQualitative /
    Exact GENESIS implementation
    50
  • MAPK_network_
    2003
  • Bhalla US Biophys J. 2004 Aug;87(2):745-53. ( peer-reviewed publication ) /
     2003-04-28 00:00:00
    Generic mammalian /
    Brain - Neuronal
    SynapseQualitative /
    Exact GENESIS implementation
    27MAPK_oscBoris N. Kholodenko Eur J Biochem. (2000) 267(6):1583-8). ( peer-reviewed publication ) /
     2002-01-22 00:00:00
    Xenopus /
    Oocyte extract
    CytosolHypothetical /
    Mathematically equivalent
    4
  • mkp1_feedback_
    effects
  • Bhalla US et al. Science (2002) 297(5583):1018-23. ( peer-reviewed publication ) /
     2001-11-07 00:00:00
    Generic mammalian /
    NIH 3T3 Expression
    Surface - nucleusQuantitative match to experiments /
    Exact GENESIS implementation
    102modifierBhalla US.PLoS Comput Biol 2021 Nov 29;17(11):e1009621. /
     2022-09-30 22:13:03
    Generic /
    cytosolFit to elementary ODE model /
    HillTau implementation
    94mRNA synthesisPeer-reviewed publication,Book /
     2014-06-10 00:00:00
    General Mammalian/Neuronal /
    Neuronal
    Surface,Cytosol, NucleusQuantitative match to experiments,Approximate implementation,Qualitative,Qualitative /
    Approximate implementation
    92mTOR_pathwayJain P, and Bhalla, U.S. PLoS Comput Biol. 2009 Feb;5(2). ( Peer-reviewed publication ) /
     2009-02-13 00:00:00
    General Mammalian /
    Neuronal
    DendriticQuantitative match to experiments /
    Approximate implementation
    74NMArginineAbu-Soud HM et al. Biochemistry. 1999 Sep 21;38(38):12446-51. ( Peer-reviewed publication ) /
     2006-08-07 00:00:00
    human /
    Kidney cell expressing the rat brain nNOS
    CytosolQuantitative match to experiments /
    Exact GENESIS implementation
    75NOHArginineAbu-Soud HM et al. Biochemistry. 1999 Sep 21;38(38):12446-51. ( Peer-reviewed publication ) /
     2006-08-07 00:00:00
    human /
    Kidney cell expressing the rat brain nNOS
    CytosolQuantitative match to experiments /
    Exact GENESIS implementation
    23
  • NonOsc_Ca_
    IP3metabolism
  • Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316. ( peer-reviewed publication ) /
     2002-01-07 00:00:00
    Generic mammalian /
    Brain - Neuronal
    CytosolQuantitative match to experiments, Qualitative /
    Approximate implementation
    31
  • NonOsc_Ca_
    IP3metabolism
  • Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316. ( peer-reviewed publication ) /
     2002-04-03 00:00:00
    Generic mammalian /
    Brain - Neuronal
    CytosolQuantitative match to experiments, Qualitative /
    Exact GENESIS implementation
    11NOS_IwanagaIn-house. /
     2001-11-12 00:00:00
    Rat; Mammalian /
    Neuronal; Expression in E.coli
    CytosolQuantitative match to experiments /
    Exact GENESIS implementation
    20
  • NOS_Phosph_
    regulation
  • In-house /
     2001-12-25 00:00:00
    rat; Mammalian /
    Brain - Neuronal; expressed in E.coli
    CytosolQuantitative match to experiments, Qualitative /
    Exact GENESIS implementation
    111oscBhalla US. PLoS Comput Biol 2021 Nov 29;17(11):e1009621.  /
     2022-10-01 00:05:03
    Generic /
    cytosolAbstract phenomenological model /
    HillTau implementation
    32
  • Osc_Ca_
    IP3metabolism
  • Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316. ( peer-reviewed publication ) /
     2002-04-03 00:00:00
    Generic mammalian /
    Brain - Neuronal
    CytosolQuantitative match to experiments, Qualitative /
    Exact GENESIS implementation
    24
  • Osc_Ca_
    IP3metabolism
  • Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316. ( peer-reviewed publication ) /
     2002-01-08 00:00:00
    Generic mammalian /
    Brain - Neuronal
    CytosolQuantitative match to experiments, Qualitative /
    Approximate implementation
    47PKA_2003Bhalla US. (2004) Biophys J. 87(2):733-44. ( peer-reviewed publication ) /
     2003-04-28 00:00:00
    Generic mammalian /
    Generic
    Cytosol + Cell membraneQualitative /
    Exact GENESIS implementation