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Accession
No.
NameSource /
Entry Date
Species /
Tissue
Cell CompartmentMethodology /
Model Implementation
46
  • MAPK_Asthagiri_
    enz_fb
  • Asthagiri AR and Lauffenburger DA. Biotechnol Prog. (2001) 17(2):227-39. ( peer-reviewed publication ). /
     2003-02-22 00:00:00
    Chinese hamster (Cricetulus griseus); mammalian /
    Ovary - CHO cell line
    Surface + cytosolQualitative /
    Approximate implementation
    44
  • MAPK_Asthagiri_
    no_fb
  • Asthagiri AR and Lauffenburger DA. Biotechnol Prog. (2001) 17(2):227-39. ( peer-reviewed publication ). /
     2003-02-22 00:00:00
    Chinese hamster (Cricetulus griseus); mammalian /
    Ovary - CHO cell line
    Surface, cytosolQuantitative match to experiments, Qualitative /
    Mathematically equivalent
    45
  • MAPK_Asthagiri_
    adapt_fb
  • Asthagiri AR and Lauffenburger DA. Biotechnol Prog. (2001) 17(2):227-39. ( peer-reviewed publication ). /
     2003-02-22 00:00:00
    Chinese hamster (Cricetulus griseus); mammalian /
    Ovary - CHO cell line
    Surface, cytosolQuantitative match to experiments, Qualitative /
    Mathematically equivalent
    13PLCbeta1In-house  /
     2001-11-12 00:00:00
    Bovine; Mammalian /
    Brain - Neuronal; expressed in E.coli
    Cell MembraneQualitative /
    Exact GENESIS implementation
    25cAMP_pathwayBhalla US Methods Enzymol. 2002;345:3-23). ( peer-reviewed publication ) /
     2002-01-12 00:00:00
    Generic mammalian /
    Brain - Neuronal
    Cell membrane + CytosolQuantitative match to experiments, Qualitative /
    Exact GENESIS implementation
    57ChemotaxisBray et al. Mol.Biol.Cell (1993) 4(5): 469-482. ( peer-reviewed publication ) /
     2003-06-10 00:00:00
    E. Coli /
    -
    Cell membrane + cytosolQualitative /
    Mathematically equivalent
    55ChemotaxisBray et al. Mol.Biol.Cell (1993) 4(5): 469-482. ( peer-reviewed publication ) /
     2003-06-10 00:00:00
    E. Coli /
    -
    Cell membrane + cytosolQuantitative match to experiments /
    Mathematically equivalent
    52
  • EGFR_Signaling_
    pathway
  • Quantification of Short Term Signaling by the EGFR Kholodenko et al, The J Biol Chem. , Vol 274, No. 42, Issue of October 15, pp. 30169 - 30181, 1999. ( peer-reviewed publication ) /
     2003-05-17 00:00:00
    Harlan Sprague Dawley rat; mammalian /
    Hepatocytes
    Cell membrane + cytosolQualitative /
    Mathematically equivalent
    26PKC_turnoverIn-house  /
     2002-01-22 00:00:00
    Generic mammalian /
    Brain - Neuronal
    Cell membrane +CytosolQuantitative match to experiments, Qualitative /
    Exact GENESIS implementation
    91
  • Protein_
    synthesis
  • Jain P, and Bhalla, U.S. PLoS Comput Biol. 2009 Feb;5(2). ( Peer-reviewed publication ) /
     2009-02-12 00:00:00
    General Mammalian /
    -
    Cell membrane, CytosolQuantitative match to experiments, Hypothetical /
    Exact GENESIS implementation
    96BCMBhalla PLoS Comput Biol 2021 (peer reviewed publication) /
     2022-05-19 00:00:00
    General Mammalian /
    Neuronal
    Cell membrane/cytosolQualitative /
    Reduced ODE model
    108bcm_bistableBhalla US. PLoS Comput Biol 2021 Nov 29;17(11):e1009621.  /
     2022-09-30 23:49:58
    Generic /
    cytosolAbstract phenomenological model /
    HillTau implementation
    43
  • CDK2-CyclinA_
    activation_
    improved
  • Morris MC. et al. J Biol Chem. (2002) 277(26):23847-53. ( peer-reviewed publication ) /
     2003-01-11 00:00:00
    Human, Xenopus /
    Expressed in E.coli
    CytosolQuantitative match to experiments /
    Exact GENESIS implementation
    105kholodenkoBhalla US.PLoS Comput Biol 2021 Nov 29;17(11):e1009621. /
     2022-09-30 22:18:08
    Xenopus /
    Oocyte extract
    cytosolFit to ODE model and experiments /
    HillTau implementation
    104fb_inhibBhalla US.PLoS Comput Biol 2021 Nov 29;17(11):e1009621. /
     2022-09-30 22:16:21
    Generic /
    cytosolAbstract phenomenological model /
    HillTau implementation
    103gainBhalla US.PLoS Comput Biol 2021 Nov 29;17(11):e1009621. /
     2022-09-30 22:14:44
    Generic /
    cytosolFit to elementary ODE model /
    HillTau implementation
    101
  • exc_tau_
    baseline
  • Bhalla US.PLoS Comput Biol 2021 Nov 29;17(11):e1009621. /
     2022-09-30 22:10:56
    Generic /
    cytosolFit to elementary ODE model /
    HillTau implementation
    102modifierBhalla US.PLoS Comput Biol 2021 Nov 29;17(11):e1009621. /
     2022-09-30 22:13:03
    Generic /
    cytosolFit to elementary ODE model /
    HillTau implementation
    106bistableBhalla US.PLoS Comput Biol 2021 Nov 29;17(11):e1009621. /
     2022-09-30 22:20:03
    Generic /
    cytosolAbstract phenomenological model /
    HillTau implementation
    68RepressilatorElowitz MB, Leibler S., Nature. 2000 Jan 20;403(6767):335-8. ( Peer-reviewed publication ) /
     2006-02-13 00:00:00
    E. Coli /
    E.coli Expression, Transposon, Lambda phage
    CytosolQualitative /
    Exact GENESIS implementation
    71RasGTPasePhillips RA et al Biochemistry. 2003 Apr 8;42(13):3956-65. ( Peer-reviewed publication ) /
     2006-05-12 00:00:00
    General Mammalian /
    E.coli Expression system
    CytosolQualitative /
    Exact GENESIS implementation
    72L-ArginineAbu-Soud HM et al. Biochemistry. 1999 Sep 21;38(38):12446-51. ( Peer-reviewed publication ) /
     2006-08-07 00:00:00
    Human /
    Kidney cell expressing the rat brain nNOS
    CytosolQuantitative match to experiments /
    Exact GENESIS implementation
    73HomoArginineAbu-Soud HM et al. Biochemistry. 1999 Sep 21;38(38):12446-51. ( Peer-reviewed publication ) /
     2006-08-07 00:00:00
    human /
    Kidney cell expressing the rat brain nNOS
    CytosolQuantitative match to experiments /
    Exact GENESIS implementation
    74NMArginineAbu-Soud HM et al. Biochemistry. 1999 Sep 21;38(38):12446-51. ( Peer-reviewed publication ) /
     2006-08-07 00:00:00
    human /
    Kidney cell expressing the rat brain nNOS
    CytosolQuantitative match to experiments /
    Exact GENESIS implementation
    75NOHArginineAbu-Soud HM et al. Biochemistry. 1999 Sep 21;38(38):12446-51. ( Peer-reviewed publication ) /
     2006-08-07 00:00:00
    human /
    Kidney cell expressing the rat brain nNOS
    CytosolQuantitative match to experiments /
    Exact GENESIS implementation
    97excBhalla US.PLoS Comput Biol 2021 Nov 29;17(11):e1009621. /
     2022-09-30 15:13:55
    Generic /
    cytosolFit to elementary ODE model /
    HillTau implementation
    98exc2ndOrderBhalla US.PLoS Comput Biol 2021 Nov 29;17(11):e1009621. /
     2022-09-30 17:52:22
    Generic /
    cytosolFit to elementary ODE model /
    HillTau implementation
    99convBhalla US.PLoS Comput Biol 2021 Nov 29;17(11):e1009621. /
     2022-09-30 17:54:52
    Generic /
    cytosolFit to elementary ODE model /
    HillTau implementation
    100inhBhalla US.PLoS Comput Biol 2021 Nov 29;17(11):e1009621. /
     2022-09-30 22:08:48
    Generic /
    cytosolFit to elementary ODE model /
    HillTau implementation
    42
  • CDK2-CyclinA_
    activation_
    pathway
  • Morris MC. et al. J Biol Chem. (2002) 277(26):23847-53. ( peer-reviewed publication ) /
     2003-01-11 00:00:00
    Human, Xenopus /
    Expressed in E.coli
    CytosolQualitative /
    Exact GENESIS implementation
    12Stuehr_NOS Santolini J. et al. J Biol Chem. (2001) 276(2):1233-43. ( peer-reviewed publication ) /
     2001-11-12 00:00:00
    Generic mammalian /
    Neuronal ; Expressioned in E.coli
    CytosolQuantitative match to experiments /
    Approximate implementation
    15
  • sGC_Stone_
    Marletta
  • Stone JR, Marletta MA. Biochemistry (1996) 35(4):1093-9. ( peer-reviewed publication ) /
     2001-12-12 00:00:00
    Bovine /
    Lungs
    CytosolQuantitative match to experiments /
    Mathematically equivalent
    112conv2ndOrderBhalla US. PLoS Comput Biol 2021 Nov 29;17(11):e1009621.  /
     2022-10-01 00:07:32
    Generic /
    cytosolFit to elementary ODE model /
    HillTau implementation
    111oscBhalla US. PLoS Comput Biol 2021 Nov 29;17(11):e1009621.  /
     2022-10-01 00:05:03
    Generic /
    cytosolAbstract phenomenological model /
    HillTau implementation
    19CondorelliGCCondorelli P, George SC. Biophys J. (2001) 80(5):2110-9). ( peer-reviewed publication  /
     2001-12-25 00:00:00
    Generic mammalian /
    Pulmonary and vascular smooth muscle
    CytosolQuantitative match to experiments /
    Mathematically equivalent
    20
  • NOS_Phosph_
    regulation
  • In-house /
     2001-12-25 00:00:00
    rat; Mammalian /
    Brain - Neuronal; expressed in E.coli
    CytosolQuantitative match to experiments, Qualitative /
    Exact GENESIS implementation
    23
  • NonOsc_Ca_
    IP3metabolism
  • Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316. ( peer-reviewed publication ) /
     2002-01-07 00:00:00
    Generic mammalian /
    Brain - Neuronal
    CytosolQuantitative match to experiments, Qualitative /
    Approximate implementation
    24
  • Osc_Ca_
    IP3metabolism
  • Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316. ( peer-reviewed publication ) /
     2002-01-08 00:00:00
    Generic mammalian /
    Brain - Neuronal
    CytosolQuantitative match to experiments, Qualitative /
    Approximate implementation
    27MAPK_oscBoris N. Kholodenko Eur J Biochem. (2000) 267(6):1583-8). ( peer-reviewed publication ) /
     2002-01-22 00:00:00
    Xenopus /
    Oocyte extract
    CytosolHypothetical /
    Mathematically equivalent
    28
  • CO_activation_
    of_GC
  • In-house  /
     2002-01-22 00:00:00
    Bovine /
    Lungs
    CytosolQuantitative match to experiments, Qualitative /
    Exact GENESIS implementation