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Reaction Name | Accession Name / Accession No. | Pathway Name / Pathway No. | Kf | Kb | Kd | tau | Reagents |
1 | CaM_act_CaMKII | BCM
Accession No. 96 | bcm
Pathway No. 1118 | 0.1 (uM^-1 s^-1) | 0.1 (s^-1) | Kd(bf) = 1(uM) | - | Substrate: Ca4.CaM CaMKII
Products: act_CaMKII
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2 | dephosp_CaMKIII | CaMKIII
Accession No. 90 | Shared_Object_ CaMKIII Pathway No. 1093 | 0.07 (s^-1) | 0 (s^-1) | - | - | Substrate: CaMKIII*
Products: CaMKIII
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3 | CaMKIII_bind_ CaM-Ca4 | CaMKIII
Accession No. 90 | Shared_Object_ CaMKIII Pathway No. 1093 | 99 (uM^-1 s^-1) | 0.09 (s^-1) | Kd(bf) = 0.0009(uM) | - | Substrate: CaM-Ca4 CaMKIII
Products: CaMKIII_CaM-Ca4
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4 | CaMKII-bind-CaM | Ajay_Bhalla_ 2004_Feedback_ Tuning Accession No. 78 | CaMKII
Pathway No. 357 | 49.9995 (uM^-1 s^-1) | 5 (s^-1) | Kd(bf) = 0.1(uM) | - | Substrate: CaM-Ca4 CaMKII
Products: CaMKII-CaM
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| This is tricky. There is some cooperativity here arising from interactions between the subunits of the CAMKII holoenzyme. However, the stoichiometry is 1. Kb/Kf = 6e4 #/cell. Rate is fast (see Hanson et al Neuron 12 943-956 1994) so lets say kb = 10. This gives kf = 1.6667e-4 H&S AnnRev Biochem 92 give tau for dissoc as 0.2 sec at low Ca, 0.4 at high. Low Ca = 100 nM = physiol. | 5 | CaMKII-bind-CaM | Ajay_Bhalla_ 2004_PKM_MKP3_ Tuning Accession No. 77 | CaMKII
Pathway No. 339 | 49.9995 (uM^-1 s^-1) | 5 (s^-1) | Kd(bf) = 0.1(uM) | - | Substrate: CaM-Ca4 CaMKII
Products: CaMKII-CaM
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| This is tricky. There is some cooperativity here arising from interactions between the subunits of the CAMKII holoenzyme. However, the stoichiometry is 1. Kb/Kf = 6e4 #/cell. Rate is fast (see Hanson et al Neuron 12 943-956 1994) so lets say kb = 10. This gives kf = 1.6667e-4 H&S AnnRev Biochem 92 give tau for dissoc as 0.2 sec at low Ca, 0.4 at high. Low Ca = 100 nM = physiol. | 6 | CaMKII-bind-CaM | Ajay_Bhalla_ 2004_PKM_Tuning Accession No. 76 | CaMKII
Pathway No. 322 | 49.9995 (uM^-1 s^-1) | 5 (s^-1) | Kd(bf) = 0.1(uM) | - | Substrate: CaM-Ca4 CaMKII
Products: CaMKII-CaM
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| This is tricky. There is some cooperativity here arising from interactions between the subunits of the CAMKII holoenzyme. However, the stoichiometry is 1. Kb/Kf = 6e4 #/cell. Rate is fast (see Hanson et al Neuron 12 943-956 1994) so lets say kb = 10. This gives kf = 1.6667e-4 H&S AnnRev Biochem 92 give tau for dissoc as 0.2 sec at low Ca, 0.4 at high. Low Ca = 100 nM = physiol. | 7 | CaMKII-bind-CaM | AMPAR_CaMKII_ weak_coupling Accession No. 65 | CaMKII
Pathway No. 282 | 49.9997 (uM^-1 s^-1) | 5 (s^-1) | Kd(bf) = 0.1(uM) | - | Substrate: CaM-Ca4 CaMKII
Products: CaMKII-CaM
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| This is tricky. There is some cooperativity here arising from interactions between the subunits of the CAMKII holoenzyme. However, the stoichiometry is 1. Kb/Kf = 6e4 #/cell. Rate is fast (see Hanson et al Neuron 12 943-956 1994) so lets say kb = 10. This gives kf = 1.6667e-4 H&S AnnRev Biochem 92 give tau for dissoc as 0.2 sec at low Ca, 0.4 at high. Low Ca = 100 nM = physiol. | 8 | Stoch_Basal_ CaMKII_PSD | AMPAR_CaMKII_ weak_coupling Accession No. 65 | CaMKII_PSD
Pathway No. 292 | 1 (s^-1) | 1 (s^-1) | Keq = 1(uM) | 0.5sec | Substrate: basal_CaMKII_ PSD_control
Products: basal_CaMKII_ PSD
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| This reaction comes into play when stochastic calculations are used. If we do not have a stochastic step here then the levels of basal_CaMKII_PSD are just a fixed number, which is probably not a good representation of stochasticity. Having a reaction for the basal activity ensures that the basal activity too exhibits some fluctuations. | 9 | CaMKII-diss-CaM | AMPAR_CaMKII_ weak_coupling Accession No. 65 | CaMKII_PSD
Pathway No. 292 | 5 (s^-1) | 0 (uM^-1 s^-1) | - | - | Substrate: CaMKII-CaM-PSD
Products: CaM-Ca4-PSD CaMKII-PSD
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10 | CaMKII-bind-CaM- PSD | AMPAR_CaMKII_ weak_coupling Accession No. 65 | CaMKII_PSD
Pathway No. 292 | 49.9998 (uM^-1 s^-1) | 0 (s^-1) | - | - | Substrate: CaMKII-PSD CaM-Ca4-PSD
Products: CaMKII-CaM-PSD
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11 | CaMKII-thr286-bi nd-CaM-PSD | AMPAR_CaMKII_ weak_coupling Accession No. 65 | CaMKII_PSD
Pathway No. 292 | 1000.02 (uM^-1 s^-1) | 0.1 (s^-1) | Kd(bf) = 0.0001(uM) | - | Substrate: CaMKII-thr286-PS D CaM-Ca4-PSD
Products: CaMKII-thr286-Ca M-PSD
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| Same values as for the main compartment Can the main compartment pool of Ca/CaM be used? | 12 | CaMKII-bind-CaM | AMPAR_CaMKII_ strong_coupling Accession No. 64 | CaMKII
Pathway No. 272 | 49.9997 (uM^-1 s^-1) | 5 (s^-1) | Kd(bf) = 0.1(uM) | - | Substrate: CaM-Ca4 CaMKII
Products: CaMKII-CaM
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| This is tricky. There is some cooperativity here arising from interactions between the subunits of the CAMKII holoenzyme. However, the stoichiometry is 1. Kb/Kf = 6e4 #/cell. Rate is fast (see Hanson et al Neuron 12 943-956 1994) so lets say kb = 10. This gives kf = 1.6667e-4 H&S AnnRev Biochem 92 give tau for dissoc as 0.2 sec at low Ca, 0.4 at high. Low Ca = 100 nM = physiol. | 13 | CaMKII-bind-CaM- PSD | AMPAR_CaMKII_ strong_coupling Accession No. 64 | Shared_Object_ AMPAR_CaMKII_ strong_coupling Pathway No. 271 | 49.9998 (uM^-1 s^-1) | 0 (s^-1) | - | - | Substrate: CaMKII-PSD CaM-Ca4-PSD
Products: CaMKII-CaM-PSD
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14 | CaMKII-thr286-bi nd-CaM-PSD | AMPAR_CaMKII_ strong_coupling Accession No. 64 | Shared_Object_ AMPAR_CaMKII_ strong_coupling Pathway No. 271 | 1000.02 (uM^-1 s^-1) | 0.1 (s^-1) | Kd(bf) = 0.0001(uM) | - | Substrate: CaMKII-thr286-PS D CaM-Ca4-PSD
Products: CaMKII-thr286-Ca M-PSD
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| Same values as for the main compartment Can the main compartment pool of Ca/CaM be used? | 15 | CaMKII-diss-CaM | AMPAR_CaMKII_ strong_coupling Accession No. 64 | Shared_Object_ AMPAR_CaMKII_ strong_coupling Pathway No. 271 | 5 (s^-1) | 0 (uM^-1 s^-1) | - | - | Substrate: CaMKII-CaM-PSD
Products: CaM-Ca4-PSD CaMKII-PSD
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16 | Stoch_Basal_ CaMKII_PSD | AMPAR_CaMKII_ strong_coupling Accession No. 64 | Shared_Object_ AMPAR_CaMKII_ strong_coupling Pathway No. 271 | 1 (s^-1) | 1 (s^-1) | Keq = 1(uM) | 0.5sec | Substrate: basal_CaMKII_ PSD_control
Products: basal_CaMKII_ PSD
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17 | CaMKII-bind-CaM | CaMKII_model3
Accession No. 63 | CaMKII
Pathway No. 264 | 49.9997 (uM^-1 s^-1) | 5 (s^-1) | Kd(bf) = 0.1(uM) | - | Substrate: CaM-Ca4 CaMKII
Products: CaMKII-CaM
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| This is tricky. There is some cooperativity here arising from interactions between the subunits of the CAMKII holoenzyme. However, the stoichiometry is 1. Kb/Kf = 6e4 #/cell. Rate is fast (see Hanson et al Neuron 12 943-956 1994) so lets say kb = 10. This gives kf = 1.6667e-4 H&S AnnRev Biochem 92 give tau for dissoc as 0.2 sec at low Ca, 0.4 at high. Low Ca = 100 nM = physiol. | 18 | CaMKII-bind-CaM- PSD | CaMKII_model3
Accession No. 63 | Shared_Object_ CaMKII_model3 Pathway No. 263 | 49.9998 (uM^-1 s^-1) | 0 (s^-1) | - | - | Substrate: CaMKII-PSD CaM-Ca4-PSD
Products: CaMKII-CaM-PSD
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19 | CaMKII-thr286-bi nd-CaM-PSD | CaMKII_model3
Accession No. 63 | Shared_Object_ CaMKII_model3 Pathway No. 263 | 1000.02 (uM^-1 s^-1) | 0.1 (s^-1) | Kd(bf) = 0.0001(uM) | - | Substrate: CaMKII-thr286-PS D CaM-Ca4-PSD
Products: CaMKII-thr286-Ca M-PSD
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| Same values as for the main compartment Can the main compartment pool of Ca/CaM be used? | 20 | CaMKII-diss-CaM | CaMKII_model3
Accession No. 63 | Shared_Object_ CaMKII_model3 Pathway No. 263 | 5 (s^-1) | 0 (uM^-1 s^-1) | - | - | Substrate: CaMKII-CaM-PSD
Products: CaM-Ca4-PSD CaMKII-PSD
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