| |
Reaction
Name | Accession Name /
Accession No. | Pathway Name /
Pathway No. | Kf | Kb | Kd | tau | Reagents |
| 1 | CaM_act_CaMKII | BCM
Accession No. 96 | bcm
Pathway No. 1118 | 0.1
(uM^-1 s^-1) | 0.1
(s^-1) | Kd(bf) = 1(uM) | - | Substrate:
Ca4.CaM
CaMKII
Products:
act_CaMKII
|
| 2 | dephosp_CaMKIII | CaMKIII
Accession No. 90 | Shared_Object_
CaMKIII
Pathway No. 1093 | 0.07
(s^-1) | 0
(s^-1) | - | - | Substrate:
CaMKIII*
Products:
CaMKIII
|
| 3 | CaMKIII_bind_
CaM-Ca4 | CaMKIII
Accession No. 90 | Shared_Object_
CaMKIII
Pathway No. 1093 | 99
(uM^-1 s^-1) | 0.09
(s^-1) | Kd(bf) = 0.0009(uM) | - | Substrate:
CaM-Ca4
CaMKIII
Products:
CaMKIII_CaM-Ca4
|
| 4 | CaMKII-bind-CaM | Ajay_Bhalla_
2004_Feedback_
Tuning
Accession No. 78 | CaMKII
Pathway No. 357 | 49.9995
(uM^-1 s^-1) | 5
(s^-1) | Kd(bf) = 0.1(uM) | - | Substrate:
CaM-Ca4
CaMKII
Products:
CaMKII-CaM
|
| This is tricky. There is some cooperativity here arising from interactions between the subunits of the CAMKII holoenzyme. However, the stoichiometry is 1. Kb/Kf = 6e4 #/cell. Rate is fast (see Hanson et al Neuron 12 943-956 1994) so lets say kb = 10. This gives kf = 1.6667e-4 H&S AnnRev Biochem 92 give tau for dissoc as 0.2 sec at low Ca, 0.4 at high. Low Ca = 100 nM = physiol. | | 5 | CaMKII-bind-CaM | Ajay_Bhalla_
2004_PKM_MKP3_
Tuning
Accession No. 77 | CaMKII
Pathway No. 339 | 49.9995
(uM^-1 s^-1) | 5
(s^-1) | Kd(bf) = 0.1(uM) | - | Substrate:
CaM-Ca4
CaMKII
Products:
CaMKII-CaM
|
| This is tricky. There is some cooperativity here arising from interactions between the subunits of the CAMKII holoenzyme. However, the stoichiometry is 1. Kb/Kf = 6e4 #/cell. Rate is fast (see Hanson et al Neuron 12 943-956 1994) so lets say kb = 10. This gives kf = 1.6667e-4 H&S AnnRev Biochem 92 give tau for dissoc as 0.2 sec at low Ca, 0.4 at high. Low Ca = 100 nM = physiol. | | 6 | CaMKII-bind-CaM | Ajay_Bhalla_
2004_PKM_Tuning
Accession No. 76 | CaMKII
Pathway No. 322 | 49.9995
(uM^-1 s^-1) | 5
(s^-1) | Kd(bf) = 0.1(uM) | - | Substrate:
CaM-Ca4
CaMKII
Products:
CaMKII-CaM
|
| This is tricky. There is some cooperativity here arising from interactions between the subunits of the CAMKII holoenzyme. However, the stoichiometry is 1. Kb/Kf = 6e4 #/cell. Rate is fast (see Hanson et al Neuron 12 943-956 1994) so lets say kb = 10. This gives kf = 1.6667e-4 H&S AnnRev Biochem 92 give tau for dissoc as 0.2 sec at low Ca, 0.4 at high. Low Ca = 100 nM = physiol. | | 7 | Stoch_Basal_
CaMKII_PSD | AMPAR_CaMKII_
weak_coupling
Accession No. 65 | CaMKII_PSD
Pathway No. 292 | 1
(s^-1) | 1
(s^-1) | Keq = 1(uM) | 0.5sec | Substrate:
basal_CaMKII_
PSD_control
Products:
basal_CaMKII_
PSD
|
| This reaction comes into play when stochastic calculations are used. If we do not have a stochastic step here then the levels of basal_CaMKII_PSD are just a fixed number, which is probably not a good representation of stochasticity. Having a reaction for the basal activity ensures that the basal activity too exhibits some fluctuations. | | 8 | CaMKII-diss-CaM | AMPAR_CaMKII_
weak_coupling
Accession No. 65 | CaMKII_PSD
Pathway No. 292 | 5
(s^-1) | 0
(uM^-1 s^-1) | - | - | Substrate:
CaMKII-CaM-PSD
Products:
CaM-Ca4-PSD
CaMKII-PSD
|
| 9 | CaMKII-bind-CaM-
PSD | AMPAR_CaMKII_
weak_coupling
Accession No. 65 | CaMKII_PSD
Pathway No. 292 | 49.9998
(uM^-1 s^-1) | 0
(s^-1) | - | - | Substrate:
CaMKII-PSD
CaM-Ca4-PSD
Products:
CaMKII-CaM-PSD
|
| 10 | CaMKII-thr286-bi
nd-CaM-PSD | AMPAR_CaMKII_
weak_coupling
Accession No. 65 | CaMKII_PSD
Pathway No. 292 | 1000.02
(uM^-1 s^-1) | 0.1
(s^-1) | Kd(bf) = 0.0001(uM) | - | Substrate:
CaMKII-thr286-PS
D
CaM-Ca4-PSD
Products:
CaMKII-thr286-Ca
M-PSD
|
| Same values as for the main compartment Can the main compartment pool of Ca/CaM be used? | | 11 | CaMKII-bind-CaM | AMPAR_CaMKII_
weak_coupling
Accession No. 65 | CaMKII
Pathway No. 282 | 49.9997
(uM^-1 s^-1) | 5
(s^-1) | Kd(bf) = 0.1(uM) | - | Substrate:
CaM-Ca4
CaMKII
Products:
CaMKII-CaM
|
| This is tricky. There is some cooperativity here arising from interactions between the subunits of the CAMKII holoenzyme. However, the stoichiometry is 1. Kb/Kf = 6e4 #/cell. Rate is fast (see Hanson et al Neuron 12 943-956 1994) so lets say kb = 10. This gives kf = 1.6667e-4 H&S AnnRev Biochem 92 give tau for dissoc as 0.2 sec at low Ca, 0.4 at high. Low Ca = 100 nM = physiol. | | 12 | CaMKII-bind-CaM | AMPAR_CaMKII_
strong_coupling
Accession No. 64 | CaMKII
Pathway No. 272 | 49.9997
(uM^-1 s^-1) | 5
(s^-1) | Kd(bf) = 0.1(uM) | - | Substrate:
CaM-Ca4
CaMKII
Products:
CaMKII-CaM
|
| This is tricky. There is some cooperativity here arising from interactions between the subunits of the CAMKII holoenzyme. However, the stoichiometry is 1. Kb/Kf = 6e4 #/cell. Rate is fast (see Hanson et al Neuron 12 943-956 1994) so lets say kb = 10. This gives kf = 1.6667e-4 H&S AnnRev Biochem 92 give tau for dissoc as 0.2 sec at low Ca, 0.4 at high. Low Ca = 100 nM = physiol. | | 13 | CaMKII-bind-CaM-
PSD | AMPAR_CaMKII_
strong_coupling
Accession No. 64 | Shared_Object_
AMPAR_CaMKII_
strong_coupling
Pathway No. 271 | 49.9998
(uM^-1 s^-1) | 0
(s^-1) | - | - | Substrate:
CaMKII-PSD
CaM-Ca4-PSD
Products:
CaMKII-CaM-PSD
|
| 14 | CaMKII-thr286-bi
nd-CaM-PSD | AMPAR_CaMKII_
strong_coupling
Accession No. 64 | Shared_Object_
AMPAR_CaMKII_
strong_coupling
Pathway No. 271 | 1000.02
(uM^-1 s^-1) | 0.1
(s^-1) | Kd(bf) = 0.0001(uM) | - | Substrate:
CaMKII-thr286-PS
D
CaM-Ca4-PSD
Products:
CaMKII-thr286-Ca
M-PSD
|
| Same values as for the main compartment Can the main compartment pool of Ca/CaM be used? | | 15 | CaMKII-diss-CaM | AMPAR_CaMKII_
strong_coupling
Accession No. 64 | Shared_Object_
AMPAR_CaMKII_
strong_coupling
Pathway No. 271 | 5
(s^-1) | 0
(uM^-1 s^-1) | - | - | Substrate:
CaMKII-CaM-PSD
Products:
CaM-Ca4-PSD
CaMKII-PSD
|
| 16 | Stoch_Basal_
CaMKII_PSD | AMPAR_CaMKII_
strong_coupling
Accession No. 64 | Shared_Object_
AMPAR_CaMKII_
strong_coupling
Pathway No. 271 | 1
(s^-1) | 1
(s^-1) | Keq = 1(uM) | 0.5sec | Substrate:
basal_CaMKII_
PSD_control
Products:
basal_CaMKII_
PSD
|
| 17 | CaMKII-bind-CaM | CaMKII_model3
Accession No. 63 | CaMKII
Pathway No. 264 | 49.9997
(uM^-1 s^-1) | 5
(s^-1) | Kd(bf) = 0.1(uM) | - | Substrate:
CaM-Ca4
CaMKII
Products:
CaMKII-CaM
|
| This is tricky. There is some cooperativity here arising from interactions between the subunits of the CAMKII holoenzyme. However, the stoichiometry is 1. Kb/Kf = 6e4 #/cell. Rate is fast (see Hanson et al Neuron 12 943-956 1994) so lets say kb = 10. This gives kf = 1.6667e-4 H&S AnnRev Biochem 92 give tau for dissoc as 0.2 sec at low Ca, 0.4 at high. Low Ca = 100 nM = physiol. | | 18 | CaMKII-bind-CaM-
PSD | CaMKII_model3
Accession No. 63 | Shared_Object_
CaMKII_model3
Pathway No. 263 | 49.9998
(uM^-1 s^-1) | 0
(s^-1) | - | - | Substrate:
CaMKII-PSD
CaM-Ca4-PSD
Products:
CaMKII-CaM-PSD
|
| 19 | CaMKII-thr286-bi
nd-CaM-PSD | CaMKII_model3
Accession No. 63 | Shared_Object_
CaMKII_model3
Pathway No. 263 | 1000.02
(uM^-1 s^-1) | 0.1
(s^-1) | Kd(bf) = 0.0001(uM) | - | Substrate:
CaMKII-thr286-PS
D
CaM-Ca4-PSD
Products:
CaMKII-thr286-Ca
M-PSD
|
| Same values as for the main compartment Can the main compartment pool of Ca/CaM be used? | | 20 | CaMKII-diss-CaM | CaMKII_model3
Accession No. 63 | Shared_Object_
CaMKII_model3
Pathway No. 263 | 5
(s^-1) | 0
(uM^-1 s^-1) | - | - | Substrate:
CaMKII-CaM-PSD
Products:
CaM-Ca4-PSD
CaMKII-PSD
|
and 
color.
