| |
Reaction
Name | Accession Name /
Accession No. | Pathway Name /
Pathway No. | Kf | Kb | Kd | tau | Reagents |
| 21 | CaMKII-bind-CaM | Synaptic_
Network
Accession No. 16 | CaMKII
Pathway No. 80 | 49.9998
(uM^-1 s^-1) | 5
(s^-1) | Kd(bf) = 0.1(uM) | - | Substrate:
CaM-Ca4
CaMKII
Products:
CaMKII-CaM
|
| This is tricky. There is some cooperativity here arising from interactions between the subunits of the CAMKII holoenzyme. However, the stoichiometry is 1. Kd = 0.1 uM. Rate is fast (see Hanson et al Neuron 12 943-956 1994) Hanson and Schulman 1992 AnnRev Biochem 61:559-601 give tau for dissoc as 0.2 sec at low Ca, 0.4 at high. Low Ca = 100 nM = physiol. | | 22 | CaMKII-bind-CaM | NonOsc_Ca_
IP3metabolism
Accession No. 23 | CaMKII
Pathway No. 106 | 49.9998
(uM^-1 s^-1) | 5
(s^-1) | Kd(bf) = 0.1(uM) | - | Substrate:
CaM-Ca4
CaMKII
Products:
CaMKII-CaM
|
| This is tricky. There is some cooperativity here arising from interactions between the subunits of the CAMKII holoenzyme. However, the stoichiometry is 1. Kd = 0.1 uM. Rate is fast (see Hanson et al Neuron 12 943-956 1994) Hanson and Schulman 1992 AnnRev Biochem 61:559-601 give tau for dissoc as 0.2 sec at low Ca, 0.4 at high. Low Ca = 100 nM = physiol. | | 23 | CaMKII-bind-CaM | Osc_Ca_
IP3metabolism
Accession No. 24 | CaMKII
Pathway No. 121 | 49.9998
(uM^-1 s^-1) | 5
(s^-1) | Kd(bf) = 0.1(uM) | - | Substrate:
CaM-Ca4
CaMKII
Products:
CaMKII-CaM
|
| This is tricky. There is some cooperativity here arising from interactions between the subunits of the CAMKII holoenzyme. However, the stoichiometry is 1. Kd = 0.1 uM. Rate is fast (see Hanson et al Neuron 12 943-956 1994) Hanson and Schulman 1992 AnnRev Biochem 61:559-601 give tau for dissoc as 0.2 sec at low Ca, 0.4 at high. Low Ca = 100 nM = physiol. | | 24 | CaMKII-bind-CaM | NonOsc_Ca_
IP3metabolism
Accession No. 31 | CaMKII
Pathway No. 145 | 49.9998
(uM^-1 s^-1) | 5
(s^-1) | Kd(bf) = 0.1(uM) | - | Substrate:
CaM-Ca4
CaMKII
Products:
CaMKII-CaM
|
| This is tricky. There is some cooperativity here arising from interactions between the subunits of the CAMKII holoenzyme. However, the stoichiometry is 1. Kd = 0.1 uM. Rate is fast (see Hanson et al Neuron 12 943-956 1994) Hanson and Schulman 1992 AnnRev Biochem 61:559-601 give tau for dissoc as 0.2 sec at low Ca, 0.4 at high. Low Ca = 100 nM = physiol. | | 25 | CaMKII-bind-CaM | Osc_Ca_
IP3metabolism
Accession No. 32 | CaMKII
Pathway No. 159 | 49.9998
(uM^-1 s^-1) | 5
(s^-1) | Kd(bf) = 0.1(uM) | - | Substrate:
CaM-Ca4
CaMKII
Products:
CaMKII-CaM
|
| This is tricky. There is some cooperativity here arising from interactions between the subunits of the CAMKII holoenzyme. However, the stoichiometry is 1. Kd = 0.1 uM. Rate is fast (see Hanson et al Neuron 12 943-956 1994) Hanson and Schulman 1992 AnnRev Biochem 61:559-601 give tau for dissoc as 0.2 sec at low Ca, 0.4 at high. Low Ca = 100 nM = physiol. | | 26 | CaMKII-CaMCa-bin
d-Ca | CaMKII
Accession No. 33 | CaMKII
Pathway No. 174 | 100.004
(uM^-1 s^-1) | 20
(s^-1) | Kd(bf) = 0.2(uM) | - | Substrate:
CAMKII-CaMCa
Ca
Products:
CaMKII-CaMCa2
|
| 27 | CaMKII-bind-CaM | CaMKII
Accession No. 33 | CaMKII
Pathway No. 174 | 0.2
(uM^-1 s^-1) | 2700
(s^-1) | Kd(bf) = 13500(uM) | - | Substrate:
CaM
CaMKII
Products:
CaMKII-CaM
|
| 28 | CaMKII-bind-CaMC
a | CaMKII
Accession No. 33 | CaMKII
Pathway No. 174 | 0.8
(uM^-1 s^-1) | 2700
(s^-1) | Kd(bf) = 3375.0084(uM) | - | Substrate:
CaMCa
CaMKII
Products:
CAMKII-CaMCa
|
| 29 | CaMKII-bind-CaMC
a2 | CaMKII
Accession No. 33 | CaMKII
Pathway No. 174 | 2
(uM^-1 s^-1) | 2250
(s^-1) | Kd(bf) = 1125(uM) | - | Substrate:
CaMCa2
CaMKII
Products:
CaMKII-CaMCa2
|
| 30 | CaMKII-bind-CaMC
a3 | CaMKII
Accession No. 33 | CaMKII
Pathway No. 174 | 100.004
(uM^-1 s^-1) | 22.5
(s^-1) | Kd(bf) = 0.225(uM) | - | Substrate:
CaMCa3
CaMKII
Products:
CaMKII-CaMCa3
|
| 31 | CaMKII-CaMCa2-bi
nd-Ca | CaMKII
Accession No. 33 | CaMKII
Pathway No. 174 | 100.004
(uM^-1 s^-1) | 2
(s^-1) | Kd(bf) = 0.02(uM) | - | Substrate:
CaMKII-CaMCa2
Ca
Products:
CaMKII-CaMCa3
|
| 32 | CaMKII-CaMCa3-bi
nd-Ca | CaMKII
Accession No. 33 | CaMKII
Pathway No. 174 | 100.004
(uM^-1 s^-1) | 100
(s^-1) | Kd(bf) = 1(uM) | - | Substrate:
CaMKII-CaMCa3
Ca
Products:
CaMKII-CaMCa4
|
| 33 | CaMKII-bind-CaMC
a4 | CaMKII
Accession No. 33 | CaMKII
Pathway No. 174 | 100.004
(uM^-1 s^-1) | 4.5
(s^-1) | Kd(bf) = 0.045(uM) | - | Substrate:
CaMCa4
CaMKII
Products:
CaMKII-CaMCa4
|
| 34 | CaMKII-CaM-bind-
Ca | CaMKII
Accession No. 33 | CaMKII
Pathway No. 174 | 4
(uM^-1 s^-1) | 20
(s^-1) | Kd(bf) = 5(uM) | - | Substrate:
CaMKII-CaM
Ca
Products:
CAMKII-CaMCa
|
| 35 | CaMKII-bind-CaM | CaMKII_2003
Accession No. 49 | CaMKII
Pathway No. 202 | 49.9998
(uM^-1 s^-1) | 5
(s^-1) | Kd(bf) = 0.1(uM) | - | Substrate:
CaM-Ca4
CaMKII
Products:
CaMKII-CaM
|
| This is tricky. There is some cooperativity here arising from interactions between the subunits of the CAMKII holoenzyme. However, the stoichiometry is 1. Kb/Kf = 6e4 #/cell. Rate is fast (see Hanson et al Neuron 12 943-956 1994) so lets say kb = 10. This gives kf = 1.6667e-4 H&S AnnRev Biochem 92 give tau for dissoc as 0.2 sec at low Ca, 0.4 at high. Low Ca = 100 nM = physiol. | | 36 | CaMKII-bind-CaM | MAPK_network_
2003
Accession No. 50 | CaMKII
Pathway No. 216 | 49.9998
(uM^-1 s^-1) | 5
(s^-1) | Kd(bf) = 0.1(uM) | - | Substrate:
CaM-Ca4
CaMKII
Products:
CaMKII-CaM
|
| This is tricky. There is some cooperativity here arising from interactions between the subunits of the CAMKII holoenzyme. However, the stoichiometry is 1. Kb/Kf = 6e4 #/cell. Rate is fast (see Hanson et al Neuron 12 943-956 1994) so lets say kb = 10. This gives kf = 1.6667e-4 H&S AnnRev Biochem 92 give tau for dissoc as 0.2 sec at low Ca, 0.4 at high. Low Ca = 100 nM = physiol. | | 37 | CaMKII-bind-CaM | AMPAR_traff_
model0
Accession No. 59 | CaMKII
Pathway No. 235 | 49.9997
(uM^-1 s^-1) | 5
(s^-1) | Kd(bf) = 0.1(uM) | - | Substrate:
CaM-Ca4
CaMKII
Products:
CaMKII-CaM
|
| This is tricky. There is some cooperativity here arising from interactions between the subunits of the CAMKII holoenzyme. However, the stoichiometry is 1. Kb/Kf = 6e4 #/cell. Rate is fast (see Hanson et al Neuron 12 943-956 1994) so lets say kb = 10. This gives kf = 1.6667e-4 H&S AnnRev Biochem 92 give tau for dissoc as 0.2 sec at low Ca, 0.4 at high. Low Ca = 100 nM = physiol. | | 38 | Stoch_Basal_
CaMKII_PSD | AMPAR_traff_
model0
Accession No. 59 | CaMKII
Pathway No. 235 | 1
(s^-1) | 1
(s^-1) | Keq = 1(uM) | 0.5sec | Substrate:
basal_CaMKII_
PSD_control
Products:
basal_CaMKII_
PSD
|
| 39 | CaMKII-diss-CaM | AMPAR_traff_
model0
Accession No. 59 | CaMKII
Pathway No. 235 | 5
(s^-1) | 0
(uM^-1 s^-1) | - | - | Substrate:
CaMKII-CaM-PSD
Products:
CaM-Ca4-PSD
CaMKII-PSD
|
| 40 | CaMKII-bind-CaM-
PSD | AMPAR_traff_
model0
Accession No. 59 | CaMKII
Pathway No. 235 | 49.9998
(uM^-1 s^-1) | 0
(s^-1) | - | - | Substrate:
CaMKII-PSD
CaM-Ca4-PSD
Products:
CaMKII-CaM-PSD
|
and 
color.
