| |
Reaction
Name | Accession Name /
Accession No. | Pathway Name /
Pathway No. | Kf | Kb | Kd | tau | Reagents |
| 1 | CaMKII-bind-CaM | CaMKII
Accession No. 33 | CaMKII
Pathway No. 174 | 0.2
(uM^-1 s^-1) | 2700
(s^-1) | Kd(bf) = 13500(uM) | - | Substrate:
CaM
CaMKII
Products:
CaMKII-CaM
|
| 2 | CaMKII-bind-CaMC
a | CaMKII
Accession No. 33 | CaMKII
Pathway No. 174 | 0.8
(uM^-1 s^-1) | 2700
(s^-1) | Kd(bf) = 3375.0084(uM) | - | Substrate:
CaMCa
CaMKII
Products:
CAMKII-CaMCa
|
| 3 | CaMKII-bind-CaMC
a2 | CaMKII
Accession No. 33 | CaMKII
Pathway No. 174 | 2
(uM^-1 s^-1) | 2250
(s^-1) | Kd(bf) = 1125(uM) | - | Substrate:
CaMCa2
CaMKII
Products:
CaMKII-CaMCa2
|
| 4 | CaMKII-CaMCa3-bi
nd-Ca | CaMKII
Accession No. 33 | CaMKII
Pathway No. 174 | 100.004
(uM^-1 s^-1) | 100
(s^-1) | Kd(bf) = 1(uM) | - | Substrate:
CaMKII-CaMCa3
Ca
Products:
CaMKII-CaMCa4
|
| 5 | CaMKII-bind-CaMC
a3 | CaMKII
Accession No. 33 | CaMKII
Pathway No. 174 | 100.004
(uM^-1 s^-1) | 22.5
(s^-1) | Kd(bf) = 0.225(uM) | - | Substrate:
CaMCa3
CaMKII
Products:
CaMKII-CaMCa3
|
| 6 | CaMKII-CaMCa-bin
d-Ca | CaMKII
Accession No. 33 | CaMKII
Pathway No. 174 | 100.004
(uM^-1 s^-1) | 20
(s^-1) | Kd(bf) = 0.2(uM) | - | Substrate:
CAMKII-CaMCa
Ca
Products:
CaMKII-CaMCa2
|
| 7 | CaMKII-CaM-bind-
Ca | CaMKII
Accession No. 33 | CaMKII
Pathway No. 174 | 4
(uM^-1 s^-1) | 20
(s^-1) | Kd(bf) = 5(uM) | - | Substrate:
CaMKII-CaM
Ca
Products:
CAMKII-CaMCa
|
| 8 | CaMKII-bind-CaM | fig3_CaMKII
Accession No. 2 | CaMKII
Pathway No. 13 | 49.9998
(uM^-1 s^-1) | 5
(s^-1) | Kd(bf) = 0.1(uM) | - | Substrate:
CaM-Ca4
CaMKII
Products:
CaMKII-CaM
|
| 9 | CaMKII-bind-CaM | fig4_synapse
Accession No. 3 | CaMKII
Pathway No. 26 | 49.9998
(uM^-1 s^-1) | 5
(s^-1) | Kd(bf) = 0.1(uM) | - | Substrate:
CaM-Ca4
CaMKII
Products:
CaMKII-CaM
|
| 10 | CaMKII-bind-CaM | Synaptic_
Network
Accession No. 16 | CaMKII
Pathway No. 80 | 49.9998
(uM^-1 s^-1) | 5
(s^-1) | Kd(bf) = 0.1(uM) | - | Substrate:
CaM-Ca4
CaMKII
Products:
CaMKII-CaM
|
| This is tricky. There is some cooperativity here arising from interactions between the subunits of the CAMKII holoenzyme. However, the stoichiometry is 1. Kd = 0.1 uM. Rate is fast (see Hanson et al Neuron 12 943-956 1994) Hanson and Schulman 1992 AnnRev Biochem 61:559-601 give tau for dissoc as 0.2 sec at low Ca, 0.4 at high. Low Ca = 100 nM = physiol. | | 11 | CaMKII-bind-CaM | NonOsc_Ca_
IP3metabolism
Accession No. 23 | CaMKII
Pathway No. 106 | 49.9998
(uM^-1 s^-1) | 5
(s^-1) | Kd(bf) = 0.1(uM) | - | Substrate:
CaM-Ca4
CaMKII
Products:
CaMKII-CaM
|
| This is tricky. There is some cooperativity here arising from interactions between the subunits of the CAMKII holoenzyme. However, the stoichiometry is 1. Kd = 0.1 uM. Rate is fast (see Hanson et al Neuron 12 943-956 1994) Hanson and Schulman 1992 AnnRev Biochem 61:559-601 give tau for dissoc as 0.2 sec at low Ca, 0.4 at high. Low Ca = 100 nM = physiol. | | 12 | CaMKII-bind-CaM | Osc_Ca_
IP3metabolism
Accession No. 24 | CaMKII
Pathway No. 121 | 49.9998
(uM^-1 s^-1) | 5
(s^-1) | Kd(bf) = 0.1(uM) | - | Substrate:
CaM-Ca4
CaMKII
Products:
CaMKII-CaM
|
| This is tricky. There is some cooperativity here arising from interactions between the subunits of the CAMKII holoenzyme. However, the stoichiometry is 1. Kd = 0.1 uM. Rate is fast (see Hanson et al Neuron 12 943-956 1994) Hanson and Schulman 1992 AnnRev Biochem 61:559-601 give tau for dissoc as 0.2 sec at low Ca, 0.4 at high. Low Ca = 100 nM = physiol. | | 13 | CaMKII-bind-CaM | NonOsc_Ca_
IP3metabolism
Accession No. 31 | CaMKII
Pathway No. 145 | 49.9998
(uM^-1 s^-1) | 5
(s^-1) | Kd(bf) = 0.1(uM) | - | Substrate:
CaM-Ca4
CaMKII
Products:
CaMKII-CaM
|
| This is tricky. There is some cooperativity here arising from interactions between the subunits of the CAMKII holoenzyme. However, the stoichiometry is 1. Kd = 0.1 uM. Rate is fast (see Hanson et al Neuron 12 943-956 1994) Hanson and Schulman 1992 AnnRev Biochem 61:559-601 give tau for dissoc as 0.2 sec at low Ca, 0.4 at high. Low Ca = 100 nM = physiol. | | 14 | CaMKII-bind-CaM | Osc_Ca_
IP3metabolism
Accession No. 32 | CaMKII
Pathway No. 159 | 49.9998
(uM^-1 s^-1) | 5
(s^-1) | Kd(bf) = 0.1(uM) | - | Substrate:
CaM-Ca4
CaMKII
Products:
CaMKII-CaM
|
| This is tricky. There is some cooperativity here arising from interactions between the subunits of the CAMKII holoenzyme. However, the stoichiometry is 1. Kd = 0.1 uM. Rate is fast (see Hanson et al Neuron 12 943-956 1994) Hanson and Schulman 1992 AnnRev Biochem 61:559-601 give tau for dissoc as 0.2 sec at low Ca, 0.4 at high. Low Ca = 100 nM = physiol. | | 15 | CaMKII-bind-CaM | CaMKII_2003
Accession No. 49 | CaMKII
Pathway No. 202 | 49.9998
(uM^-1 s^-1) | 5
(s^-1) | Kd(bf) = 0.1(uM) | - | Substrate:
CaM-Ca4
CaMKII
Products:
CaMKII-CaM
|
| This is tricky. There is some cooperativity here arising from interactions between the subunits of the CAMKII holoenzyme. However, the stoichiometry is 1. Kb/Kf = 6e4 #/cell. Rate is fast (see Hanson et al Neuron 12 943-956 1994) so lets say kb = 10. This gives kf = 1.6667e-4 H&S AnnRev Biochem 92 give tau for dissoc as 0.2 sec at low Ca, 0.4 at high. Low Ca = 100 nM = physiol. | | 16 | CaMKII-bind-CaM | MAPK_network_
2003
Accession No. 50 | CaMKII
Pathway No. 216 | 49.9998
(uM^-1 s^-1) | 5
(s^-1) | Kd(bf) = 0.1(uM) | - | Substrate:
CaM-Ca4
CaMKII
Products:
CaMKII-CaM
|
| This is tricky. There is some cooperativity here arising from interactions between the subunits of the CAMKII holoenzyme. However, the stoichiometry is 1. Kb/Kf = 6e4 #/cell. Rate is fast (see Hanson et al Neuron 12 943-956 1994) so lets say kb = 10. This gives kf = 1.6667e-4 H&S AnnRev Biochem 92 give tau for dissoc as 0.2 sec at low Ca, 0.4 at high. Low Ca = 100 nM = physiol. | | 17 | CaMKII-bind-CaM | AMPAR_traff_
model0
Accession No. 59 | CaMKII
Pathway No. 235 | 49.9997
(uM^-1 s^-1) | 5
(s^-1) | Kd(bf) = 0.1(uM) | - | Substrate:
CaM-Ca4
CaMKII
Products:
CaMKII-CaM
|
| This is tricky. There is some cooperativity here arising from interactions between the subunits of the CAMKII holoenzyme. However, the stoichiometry is 1. Kb/Kf = 6e4 #/cell. Rate is fast (see Hanson et al Neuron 12 943-956 1994) so lets say kb = 10. This gives kf = 1.6667e-4 H&S AnnRev Biochem 92 give tau for dissoc as 0.2 sec at low Ca, 0.4 at high. Low Ca = 100 nM = physiol. | | 18 | CaMKII-bind-CaM | AMPAR_traff_
model1
Accession No. 60 | CaMKII
Pathway No. 245 | 49.9997
(uM^-1 s^-1) | 5
(s^-1) | Kd(bf) = 0.1(uM) | - | Substrate:
CaM-Ca4
CaMKII
Products:
CaMKII-CaM
|
| This is tricky. There is some cooperativity here arising from interactions between the subunits of the CAMKII holoenzyme. However, the stoichiometry is 1. Kb/Kf = 6e4 #/cell. Rate is fast (see Hanson et al Neuron 12 943-956 1994) so lets say kb = 10. This gives kf = 1.6667e-4 H&S AnnRev Biochem 92 give tau for dissoc as 0.2 sec at low Ca, 0.4 at high. Low Ca = 100 nM = physiol. | | 19 | CaMKII-bind-CaM | CaMKII_noPKA_
model3
Accession No. 62 | CaMKII
Pathway No. 258 | 49.9997
(uM^-1 s^-1) | 5
(s^-1) | Kd(bf) = 0.1(uM) | - | Substrate:
CaM-Ca4
CaMKII
Products:
CaMKII-CaM
|
| This is tricky. There is some cooperativity here arising from interactions between the subunits of the CAMKII holoenzyme. However, the stoichiometry is 1. Kb/Kf = 6e4 #/cell. Rate is fast (see Hanson et al Neuron 12 943-956 1994) so lets say kb = 10. This gives kf = 1.6667e-4 H&S AnnRev Biochem 92 give tau for dissoc as 0.2 sec at low Ca, 0.4 at high. Low Ca = 100 nM = physiol. | | 20 | CaMKII-bind-CaM | CaMKII_model3
Accession No. 63 | CaMKII
Pathway No. 264 | 49.9997
(uM^-1 s^-1) | 5
(s^-1) | Kd(bf) = 0.1(uM) | - | Substrate:
CaM-Ca4
CaMKII
Products:
CaMKII-CaM
|
| This is tricky. There is some cooperativity here arising from interactions between the subunits of the CAMKII holoenzyme. However, the stoichiometry is 1. Kb/Kf = 6e4 #/cell. Rate is fast (see Hanson et al Neuron 12 943-956 1994) so lets say kb = 10. This gives kf = 1.6667e-4 H&S AnnRev Biochem 92 give tau for dissoc as 0.2 sec at low Ca, 0.4 at high. Low Ca = 100 nM = physiol. |
and 
color.
