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Result: 1 - 20 of 54 rows are displayed Previous of 3  Next

Reaction List for CamKII

Entries are grouped according to Reaction Name and they are alternately color coded using  and  color.
Further ordering can be done to the table header.  indicates that ordering is done according to ascending or descending order.
Keq is calculated only for first order reactions.
Kd is calculated only for second order reactions. [nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules]
  Reaction
Name		Accession Name / 
Accession No.		Pathway Name / 
Pathway No.		KfKbKdtauReagents
1 CaMKII-bind-CaM
  • Synaptic_
    Network
    Accession No. 16
    		• CaMKII

    Pathway No. 80    		49.9998
    (uM^-1 s^-1)    		5
    (s^-1)    		Kd(bf) = 0.1(uM)-  Substrate:
     CaM-Ca4
     CaMKII

     Products:
     CaMKII-CaM
      This is tricky. There is some cooperativity here arising from interactions between the subunits of the CAMKII holoenzyme. However, the stoichiometry is 1. Kd = 0.1 uM. Rate is fast (see Hanson et al Neuron 12 943-956 1994) Hanson and Schulman 1992 AnnRev Biochem 61:559-601 give tau for dissoc as 0.2 sec at low Ca, 0.4 at high. Low Ca = 100 nM = physiol.
    2 CaMKII-bind-CaM
  • Osc_Ca_
    IP3metabolism
    Accession No. 24
    		• CaMKII

    Pathway No. 121    		49.9998
    (uM^-1 s^-1)    		5
    (s^-1)    		Kd(bf) = 0.1(uM)-  Substrate:
     CaM-Ca4
     CaMKII

     Products:
     CaMKII-CaM
      This is tricky. There is some cooperativity here arising from interactions between the subunits of the CAMKII holoenzyme. However, the stoichiometry is 1. Kd = 0.1 uM. Rate is fast (see Hanson et al Neuron 12 943-956 1994) Hanson and Schulman 1992 AnnRev Biochem 61:559-601 give tau for dissoc as 0.2 sec at low Ca, 0.4 at high. Low Ca = 100 nM = physiol.
    3 CaMKII-bind-CaM
  • Osc_Ca_
    IP3metabolism
    Accession No. 32
    		• CaMKII

    Pathway No. 159    		49.9998
    (uM^-1 s^-1)    		5
    (s^-1)    		Kd(bf) = 0.1(uM)-  Substrate:
     CaM-Ca4
     CaMKII

     Products:
     CaMKII-CaM
      This is tricky. There is some cooperativity here arising from interactions between the subunits of the CAMKII holoenzyme. However, the stoichiometry is 1. Kd = 0.1 uM. Rate is fast (see Hanson et al Neuron 12 943-956 1994) Hanson and Schulman 1992 AnnRev Biochem 61:559-601 give tau for dissoc as 0.2 sec at low Ca, 0.4 at high. Low Ca = 100 nM = physiol.
    4 CaMKII-bind-CaM
  • NonOsc_Ca_
    IP3metabolism
    Accession No. 23
    		• CaMKII

    Pathway No. 106    		49.9998
    (uM^-1 s^-1)    		5
    (s^-1)    		Kd(bf) = 0.1(uM)-  Substrate:
     CaM-Ca4
     CaMKII

     Products:
     CaMKII-CaM
      This is tricky. There is some cooperativity here arising from interactions between the subunits of the CAMKII holoenzyme. However, the stoichiometry is 1. Kd = 0.1 uM. Rate is fast (see Hanson et al Neuron 12 943-956 1994) Hanson and Schulman 1992 AnnRev Biochem 61:559-601 give tau for dissoc as 0.2 sec at low Ca, 0.4 at high. Low Ca = 100 nM = physiol.
    5 CaMKII-bind-CaM
  • NonOsc_Ca_
    IP3metabolism
    Accession No. 31
    		• CaMKII

    Pathway No. 145    		49.9998
    (uM^-1 s^-1)    		5
    (s^-1)    		Kd(bf) = 0.1(uM)-  Substrate:
     CaM-Ca4
     CaMKII

     Products:
     CaMKII-CaM
      This is tricky. There is some cooperativity here arising from interactions between the subunits of the CAMKII holoenzyme. However, the stoichiometry is 1. Kd = 0.1 uM. Rate is fast (see Hanson et al Neuron 12 943-956 1994) Hanson and Schulman 1992 AnnRev Biochem 61:559-601 give tau for dissoc as 0.2 sec at low Ca, 0.4 at high. Low Ca = 100 nM = physiol.
    6 CaMKII-bind-CaM
  • MAPK_network_
    2003
    Accession No. 50
    		• CaMKII

    Pathway No. 216    		49.9998
    (uM^-1 s^-1)    		5
    (s^-1)    		Kd(bf) = 0.1(uM)-  Substrate:
     CaM-Ca4
     CaMKII

     Products:
     CaMKII-CaM
      This is tricky. There is some cooperativity here arising from interactions between the subunits of the CAMKII holoenzyme. However, the stoichiometry is 1. Kb/Kf = 6e4 #/cell. Rate is fast (see Hanson et al Neuron 12 943-956 1994) so lets say kb = 10. This gives kf = 1.6667e-4 H&S AnnRev Biochem 92 give tau for dissoc as 0.2 sec at low Ca, 0.4 at high. Low Ca = 100 nM = physiol.
    7 CaMKII-bind-CaMfig4_synapse

    Accession No. 3    		CaMKII

    Pathway No. 26    		49.9998
    (uM^-1 s^-1)    		5
    (s^-1)    		Kd(bf) = 0.1(uM)-  Substrate:
     CaM-Ca4
     CaMKII

     Products:
     CaMKII-CaM
    8 CaMKII-bind-CaMfig3_CaMKII

    Accession No. 2    		CaMKII

    Pathway No. 13    		49.9998
    (uM^-1 s^-1)    		5
    (s^-1)    		Kd(bf) = 0.1(uM)-  Substrate:
     CaM-Ca4
     CaMKII

     Products:
     CaMKII-CaM
    9 CaMKII-bind-CaM
  • CaMKII_noPKA_
    model3
    Accession No. 62
    		• CaMKII

    Pathway No. 258    		49.9997
    (uM^-1 s^-1)    		5
    (s^-1)    		Kd(bf) = 0.1(uM)-  Substrate:
     CaM-Ca4
     CaMKII

     Products:
     CaMKII-CaM
      This is tricky. There is some cooperativity here arising from interactions between the subunits of the CAMKII holoenzyme. However, the stoichiometry is 1. Kb/Kf = 6e4 #/cell. Rate is fast (see Hanson et al Neuron 12 943-956 1994) so lets say kb = 10. This gives kf = 1.6667e-4 H&S AnnRev Biochem 92 give tau for dissoc as 0.2 sec at low Ca, 0.4 at high. Low Ca = 100 nM = physiol.
    10 
  • CaMKII-bind-CaM-
    PSD
  • CaMKII_noPKA_
    model3
    Accession No. 62
  • Shared_Object_
    CaMKII_noPKA_
    model3
    Pathway No. 257
    		• 49.9998
    (uM^-1 s^-1)    		0
    (s^-1)    		--  Substrate:
     CaMKII-PSD
     CaM-Ca4-PSD

     Products:
     CaMKII-CaM-PSD
    11 
  • CaMKII-thr286-bi
    nd-CaM-PSD
  • CaMKII_noPKA_
    model3
    Accession No. 62
  • Shared_Object_
    CaMKII_noPKA_
    model3
    Pathway No. 257
    		• 1000.02
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 0.0001(uM)-  Substrate:
  •  CaMKII-thr286-PS
    D
     CaM-Ca4-PSD

     Products:
  •  CaMKII-thr286-Ca
    M-PSD
    •   Same values as for the main compartment Can the main compartment pool of Ca/CaM be used?
    12 CaMKII-diss-CaM
  • CaMKII_noPKA_
    model3
    Accession No. 62
  • Shared_Object_
    CaMKII_noPKA_
    model3
    Pathway No. 257
    		• 5
    (s^-1)    		0
    (uM^-1 s^-1)    		--  Substrate:
     CaMKII-CaM-PSD

     Products:
     CaM-Ca4-PSD
     CaMKII-PSD
    13 
  • Stoch_Basal_
    CaMKII_PSD
  • CaMKII_noPKA_
    model3
    Accession No. 62
  • Shared_Object_
    CaMKII_noPKA_
    model3
    Pathway No. 257
    		• 1
    (s^-1)    		1
    (s^-1)    		Keq = 1(uM)0.5sec  Substrate:
  •  basal_CaMKII_
    PSD_control

     Products:
  •  basal_CaMKII_
    PSD
    • 14 CaMKII-bind-CaMCaMKII_model3

    Accession No. 63    		CaMKII

    Pathway No. 264    		49.9997
    (uM^-1 s^-1)    		5
    (s^-1)    		Kd(bf) = 0.1(uM)-  Substrate:
     CaM-Ca4
     CaMKII

     Products:
     CaMKII-CaM
      This is tricky. There is some cooperativity here arising from interactions between the subunits of the CAMKII holoenzyme. However, the stoichiometry is 1. Kb/Kf = 6e4 #/cell. Rate is fast (see Hanson et al Neuron 12 943-956 1994) so lets say kb = 10. This gives kf = 1.6667e-4 H&S AnnRev Biochem 92 give tau for dissoc as 0.2 sec at low Ca, 0.4 at high. Low Ca = 100 nM = physiol.
    15 
  • CaMKII-bind-CaM-
    PSD
    		• CaMKII_model3

    Accession No. 63
  • Shared_Object_
    CaMKII_model3
    Pathway No. 263
    		• 49.9998
    (uM^-1 s^-1)    		0
    (s^-1)    		--  Substrate:
     CaMKII-PSD
     CaM-Ca4-PSD

     Products:
     CaMKII-CaM-PSD
    16 
  • CaMKII-thr286-bi
    nd-CaM-PSD
    		• CaMKII_model3

    Accession No. 63
  • Shared_Object_
    CaMKII_model3
    Pathway No. 263
    		• 1000.02
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 0.0001(uM)-  Substrate:
  •  CaMKII-thr286-PS
    D
     CaM-Ca4-PSD

     Products:
  •  CaMKII-thr286-Ca
    M-PSD
    •   Same values as for the main compartment Can the main compartment pool of Ca/CaM be used?
    17 CaMKII-diss-CaMCaMKII_model3

    Accession No. 63
  • Shared_Object_
    CaMKII_model3
    Pathway No. 263
    		• 5
    (s^-1)    		0
    (uM^-1 s^-1)    		--  Substrate:
     CaMKII-CaM-PSD

     Products:
     CaM-Ca4-PSD
     CaMKII-PSD
    18 
  • Stoch_Basal_
    CaMKII_PSD
    		• CaMKII_model3

    Accession No. 63
  • Shared_Object_
    CaMKII_model3
    Pathway No. 263
    		• 1
    (s^-1)    		1
    (s^-1)    		Keq = 1(uM)0.5sec  Substrate:
  •  basal_CaMKII_
    PSD_control

     Products:
  •  basal_CaMKII_
    PSD
    • 19 CaMKII-bind-CaMCaMKII_2003

    Accession No. 49    		CaMKII

    Pathway No. 202    		49.9998
    (uM^-1 s^-1)    		5
    (s^-1)    		Kd(bf) = 0.1(uM)-  Substrate:
     CaM-Ca4
     CaMKII

     Products:
     CaMKII-CaM
      This is tricky. There is some cooperativity here arising from interactions between the subunits of the CAMKII holoenzyme. However, the stoichiometry is 1. Kb/Kf = 6e4 #/cell. Rate is fast (see Hanson et al Neuron 12 943-956 1994) so lets say kb = 10. This gives kf = 1.6667e-4 H&S AnnRev Biochem 92 give tau for dissoc as 0.2 sec at low Ca, 0.4 at high. Low Ca = 100 nM = physiol.
    20 dephosp_CaMKIIICaMKIII

    Accession No. 90
  • Shared_Object_
    CaMKIII
    Pathway No. 1093
    		• 0.07
    (s^-1)    		0
    (s^-1)    		--  Substrate:
     CaMKIII*

     Products:
     CaMKIII
     
    Result: 1 - 20 of 54 rows are displayed Previous of 3  Next


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