|
Enter a Search String | | Special character and space not allowed in the query term.
Search string should be at least 2 characters long. |
Pathway List for cam | Default ordering is done according to Pathway Name.Table header can be used for changing the default ordering.
  indicates that ordering is done according to ascending or descending order.
Entries are color tagged depending on Network  or Pathway  |
| |
Pathway Name
Pathway No. | Accession Name
Accession No. | Accession
Type | Pathway statistics | cam statistics | Source
Entry Date | | 1 | CaM
Pathway No. 81 | Synaptic_
Network
Accession No. 16 | Network | Molecule = 4
Enzyme = 0
Reaction = 5
| Molecule = 1
Enzyme = 0
Reaction = 0
| Bhalla US and Iyengar R. Science (1999) 283(5400):381-7. ( peer-reviewed publication )/
2001-12-12 00:00:00 | | | #137Related Pathway:
14, 27, 107, 122, 146, 160, 173, 203, 217, 236, 246, 259, 265, 273, 283, 323, 340, 358, 368, 373, 379, 386, 392
398, 405, 411, 418, 423, 428, 434, 440, 446, 452, 458, 464, 470, 476, 482, 488, 494, 500, 506, 512, 518, 524, 530, 537
543, 549, 555, 561, 568, 573, 579, 585, 591, 597, 603, 609, 615, 621, 627, 633, 639, 645, 651, 657, 663, 669, 675, 681
688, 695, 701, 706, 712, 718, 724, 730, 736, 742, 748, 754, 760, 766, 772, 778, 784, 790, 796, 802, 808, 814, 820, 826
832, 838, 844, 850, 856, 862, 868, 874, 880, 886, 892, 898, 904, 910, 916, 924, 930, 936, 942, 948, 954, 961, 967, 973
979, 985, 991, 997, 1002, 1008, 1014, 1021, 1026, 1032, 1038, 1044, 1050, 1056, 1062, 1068, 1094 | | | This is the basic Ca-binding-to-CaM model with the addition of neurogranin as a CaM se
questering molecule. Main data sources are Forsen et al 1986 Calcium and Cell funciton VI 113_
157 Drabikowski and Brzeska 1982 JBC 257(19):11584-11590 Martin et al 1985 Eur J Biochem 151(3)
:543-550 Stemmer and Klee 1994 Biochem 33:6859-6866 Data is pretty thorough. The Neurogranin in
fo is from several sources esp Huang et al 1993 ABB 305(2):570-580 Gerendasy et al 1994 JBC 269
(35) 22420-22426 is not very quantitative | | | This pathway is part of accession 16 and is completely specified in the file acc16.g.
There is no separate files for just this pathway. |
| Format | File | | Native Format (GENESIS format) | acc16.g | | GENESIS Format (Annotated version) | Anno_acc16.g |
| | 2 | CaM
Pathway No. 122 | Osc_Ca_
IP3metabolism
Accession No. 24 | Network | Molecule = 4
Enzyme = 0
Reaction = 3
| Molecule = 1
Enzyme = 0
Reaction = 0
| Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316. ( peer-reviewed publication )/
2002-01-08 00:00:00 | | | #137Related Pathway:
14, 27, 81, 107, 146, 160, 173, 203, 217, 236, 246, 259, 265, 273, 283, 323, 340, 358, 368, 373, 379, 386, 392, 398
405, 411, 418, 423, 428, 434, 440, 446, 452, 458, 464, 470, 476, 482, 488, 494, 500, 506, 512, 518, 524, 530, 537, 543
549, 555, 561, 568, 573, 579, 585, 591, 597, 603, 609, 615, 621, 627, 633, 639, 645, 651, 657, 663, 669, 675, 681, 688
695, 701, 706, 712, 718, 724, 730, 736, 742, 748, 754, 760, 766, 772, 778, 784, 790, 796, 802, 808, 814, 820, 826, 832
838, 844, 850, 856, 862, 868, 874, 880, 886, 892, 898, 904, 910, 916, 924, 930, 936, 942, 948, 954, 961, 967, 973, 979
985, 991, 997, 1002, 1008, 1014, 1021, 1026, 1032, 1038, 1044, 1050, 1056, 1062, 1068, 1094 | | | This is the basic Ca-binding-to-CaM model. Main data sources are Forsen et al 1986 Calcium and Cell funciton VI 113_157 Drabikowski and Brzeska 1982 JBC 257(19):11584-11590 Martin et al 1985 Eur J Biochem 151(3):543-550 Stemmer and Klee 1994 Biochem 33:6859-6866 Data is pretty thorough. | | | This pathway is part of accession 24 and is completely specified in the file acc24.g.
There is no separate files for just this pathway. |
| Format | File | | Native Format (GENESIS format) | acc24.g | | GENESIS Format (Annotated version) | Anno_acc24.g |
| | 3 | CaM
Pathway No. 160 | Osc_Ca_
IP3metabolism
Accession No. 32 | Network | Molecule = 4
Enzyme = 0
Reaction = 3
| Molecule = 1
Enzyme = 0
Reaction = 0
| Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316. ( peer-reviewed publication )/
2002-04-03 00:00:00 | | | #137Related Pathway:
14, 27, 81, 107, 122, 146, 173, 203, 217, 236, 246, 259, 265, 273, 283, 323, 340, 358, 368, 373, 379, 386, 392, 398
405, 411, 418, 423, 428, 434, 440, 446, 452, 458, 464, 470, 476, 482, 488, 494, 500, 506, 512, 518, 524, 530, 537, 543
549, 555, 561, 568, 573, 579, 585, 591, 597, 603, 609, 615, 621, 627, 633, 639, 645, 651, 657, 663, 669, 675, 681, 688
695, 701, 706, 712, 718, 724, 730, 736, 742, 748, 754, 760, 766, 772, 778, 784, 790, 796, 802, 808, 814, 820, 826, 832
838, 844, 850, 856, 862, 868, 874, 880, 886, 892, 898, 904, 910, 916, 924, 930, 936, 942, 948, 954, 961, 967, 973, 979
985, 991, 997, 1002, 1008, 1014, 1021, 1026, 1032, 1038, 1044, 1050, 1056, 1062, 1068, 1094 | | | This is the basic Ca-binding-to-CaM model. Main data sources are Forsen et al 1986 Calcium and Cell funciton VI 113_157 Drabikowski and Brzeska 1982 JBC 257(19):11584-11590 Martin et al 1985 Eur J Biochem 151(3):543-550 Stemmer and Klee 1994 Biochem 33:6859-6866 Data is pretty thorough. | | | This pathway is part of accession 32 and is completely specified in the file acc32.g.
There is no separate files for just this pathway. |
| Format | File | | Native Format (GENESIS format) | acc32.g | | GENESIS Format (Annotated version) | Anno_acc32.g |
| | 4 | CaM
Pathway No. 107 | NonOsc_Ca_
IP3metabolism
Accession No. 23 | Network | Molecule = 4
Enzyme = 0
Reaction = 3
| Molecule = 1
Enzyme = 0
Reaction = 0
| Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316. ( peer-reviewed publication )/
2002-01-07 00:00:00 | | | #137Related Pathway:
14, 27, 81, 122, 146, 160, 173, 203, 217, 236, 246, 259, 265, 273, 283, 323, 340, 358, 368, 373, 379, 386, 392, 398
405, 411, 418, 423, 428, 434, 440, 446, 452, 458, 464, 470, 476, 482, 488, 494, 500, 506, 512, 518, 524, 530, 537, 543
549, 555, 561, 568, 573, 579, 585, 591, 597, 603, 609, 615, 621, 627, 633, 639, 645, 651, 657, 663, 669, 675, 681, 688
695, 701, 706, 712, 718, 724, 730, 736, 742, 748, 754, 760, 766, 772, 778, 784, 790, 796, 802, 808, 814, 820, 826, 832
838, 844, 850, 856, 862, 868, 874, 880, 886, 892, 898, 904, 910, 916, 924, 930, 936, 942, 948, 954, 961, 967, 973, 979
985, 991, 997, 1002, 1008, 1014, 1021, 1026, 1032, 1038, 1044, 1050, 1056, 1062, 1068, 1094 | | | This is the basic Ca-binding-to-CaM model. Main data sources are Forsen S.et al (1986) in Calcium and Cell function, volume 6 (Cheung, W. Y., ed.) pp.112-157, Academic Press, New York and Drabikowski W. et al, J Biol Chem. 1982 Oct 10;257(19):11584-90 and Martin SR et al Eur J Biochem. 1985 Sep 16;151(3):543-50 and Stemmer PM, Klee CB Biochemistry. 1994 Jun 7;33(22):6859-66 Data is pretty thorough. | | | This pathway is part of accession 23 and is completely specified in the file acc23.g.
There is no separate files for just this pathway. |
| Format | File | | Native Format (GENESIS format) | acc23.g | | GENESIS Format (Annotated version) | Anno_acc23.g |
| | 5 | CaM
Pathway No. 146 | NonOsc_Ca_
IP3metabolism
Accession No. 31 | Network | Molecule = 4
Enzyme = 0
Reaction = 3
| Molecule = 1
Enzyme = 0
Reaction = 0
| Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316. ( peer-reviewed publication )/
2002-04-03 00:00:00 | | | #137Related Pathway:
14, 27, 81, 107, 122, 160, 173, 203, 217, 236, 246, 259, 265, 273, 283, 323, 340, 358, 368, 373, 379, 386, 392, 398
405, 411, 418, 423, 428, 434, 440, 446, 452, 458, 464, 470, 476, 482, 488, 494, 500, 506, 512, 518, 524, 530, 537, 543
549, 555, 561, 568, 573, 579, 585, 591, 597, 603, 609, 615, 621, 627, 633, 639, 645, 651, 657, 663, 669, 675, 681, 688
695, 701, 706, 712, 718, 724, 730, 736, 742, 748, 754, 760, 766, 772, 778, 784, 790, 796, 802, 808, 814, 820, 826, 832
838, 844, 850, 856, 862, 868, 874, 880, 886, 892, 898, 904, 910, 916, 924, 930, 936, 942, 948, 954, 961, 967, 973, 979
985, 991, 997, 1002, 1008, 1014, 1021, 1026, 1032, 1038, 1044, 1050, 1056, 1062, 1068, 1094 | | | This is the basic Ca-binding-to-CaM model. Main data sources are Forsen et al 1986 Calcium and Cell funciton VI 113_157 Drabikowski and Brzeska 1982 JBC 257(19):11584-11590 Martin et al 1985 Eur J Biochem 151(3):543-550 Stemmer and Klee 1994 Biochem 33:6859-6866 Data is pretty thorough. | | | This pathway is part of accession 31 and is completely specified in the file acc31.g.
There is no separate files for just this pathway. |
| Format | File | | Native Format (GENESIS format) | acc31.g | | GENESIS Format (Annotated version) | Anno_acc31.g |
| | 6 | CaM
Pathway No. 217 | MAPK_network_
2003
Accession No. 50 | Network | Molecule = 4
Enzyme = 0
Reaction = 5
| Molecule = 1
Enzyme = 0
Reaction = 0
| Bhalla US Biophys J. 2004 Aug;87(2):745-53. ( peer-reviewed publication )/
2003-04-28 00:00:00 | | | #137Related Pathway:
14, 27, 81, 107, 122, 146, 160, 173, 203, 236, 246, 259, 265, 273, 283, 323, 340, 358, 368, 373, 379, 386, 392, 398
405, 411, 418, 423, 428, 434, 440, 446, 452, 458, 464, 470, 476, 482, 488, 494, 500, 506, 512, 518, 524, 530, 537, 543
549, 555, 561, 568, 573, 579, 585, 591, 597, 603, 609, 615, 621, 627, 633, 639, 645, 651, 657, 663, 669, 675, 681, 688
695, 701, 706, 712, 718, 724, 730, 736, 742, 748, 754, 760, 766, 772, 778, 784, 790, 796, 802, 808, 814, 820, 826, 832
838, 844, 850, 856, 862, 868, 874, 880, 886, 892, 898, 904, 910, 916, 924, 930, 936, 942, 948, 954, 961, 967, 973, 979
985, 991, 997, 1002, 1008, 1014, 1021, 1026, 1032, 1038, 1044, 1050, 1056, 1062, 1068, 1094 | | | This is a network model of many pathways present at the neuronal synapse. The network has properties of temporal tuning as well as steady-state computational properties. In its default form the network is bistable.Bhalla US Biophys J. 2004 Aug;87(2):745-53 | | | | | 7 | CaM
Pathway No. 27 | fig4_synapse
Accession No. 3 | Network | Molecule = 4
Enzyme = 0
Reaction = 5
| Molecule = 1
Enzyme = 0
Reaction = 0
| Bhalla US and Iyengar R. Science (1999) 283(5400):381-7. ( peer-reviewed publication )/
2001-11-07 00:00:00 | | | #137Related Pathway:
14, 81, 107, 122, 146, 160, 173, 203, 217, 236, 246, 259, 265, 273, 283, 323, 340, 358, 368, 373, 379, 386, 392
398, 405, 411, 418, 423, 428, 434, 440, 446, 452, 458, 464, 470, 476, 482, 488, 494, 500, 506, 512, 518, 524, 530, 537
543, 549, 555, 561, 568, 573, 579, 585, 591, 597, 603, 609, 615, 621, 627, 633, 639, 645, 651, 657, 663, 669, 675, 681
688, 695, 701, 706, 712, 718, 724, 730, 736, 742, 748, 754, 760, 766, 772, 778, 784, 790, 796, 802, 808, 814, 820, 826
832, 838, 844, 850, 856, 862, 868, 874, 880, 886, 892, 898, 904, 910, 916, 924, 930, 936, 942, 948, 954, 961, 967, 973
979, 985, 991, 997, 1002, 1008, 1014, 1021, 1026, 1032, 1038, 1044, 1050, 1056, 1062, 1068, 1094 | | | This is the composite model of 4 kinases: PKC, MAPK, PKA and CaMKII and numerous regulatory pathways involved in synaptic signaling. From Bhalla US and Iyengar R. Science (1999) 283(5400):381-7.This model comes from figure 4 of that paper.
Demonstration script files for generating the figures in the paper, including figure 4, are available here. | | | This pathway is part of accession 3 and is completely specified in the file acc3.g.
There is no separate files for just this pathway. |
| Format | File | | Native Format (GENESIS format) | acc3.g | | GENESIS Format (Annotated version) | Anno_acc3.g |
| | 8 | CaM
Pathway No. 14 | fig3_CaMKII
Accession No. 2 | Network | Molecule = 4
Enzyme = 0
Reaction = 5
| Molecule = 1
Enzyme = 0
Reaction = 0
| Bhalla US and Iyengar R. Science (1999) 283(5400):381-7. ( peer-reviewed publication )/
2001-11-07 00:00:00 | | | #137Related Pathway:
27, 81, 107, 122, 146, 160, 173, 203, 217, 236, 246, 259, 265, 273, 283, 323, 340, 358, 368, 373, 379, 386, 392
398, 405, 411, 418, 423, 428, 434, 440, 446, 452, 458, 464, 470, 476, 482, 488, 494, 500, 506, 512, 518, 524, 530, 537
543, 549, 555, 561, 568, 573, 579, 585, 591, 597, 603, 609, 615, 621, 627, 633, 639, 645, 651, 657, 663, 669, 675, 681
688, 695, 701, 706, 712, 718, 724, 730, 736, 742, 748, 754, 760, 766, 772, 778, 784, 790, 796, 802, 808, 814, 820, 826
832, 838, 844, 850, 856, 862, 868, 874, 880, 886, 892, 898, 904, 910, 916, 924, 930, 936, 942, 948, 954, 961, 967, 973
979, 985, 991, 997, 1002, 1008, 1014, 1021, 1026, 1032, 1038, 1044, 1050, 1056, 1062, 1068, 1094 | | | This is the model file for figure 3 from Bhalla US and Iyengar R. Science (1999) 283(5400):381-7. It is a model of the Ca activation of CaMKII and other CaM-activated enzymes. It includes the regulatory phosphatases PP1 and PP2B (Calcineurin) acting on CaMKII and also includes CaM-activated adenylyl cyclase and PKA in the synapse.
Demonstration script files for generating the figures in the paper, including figure 3, are available here. | | | This pathway is part of accession 2 and is completely specified in the file acc2.g.
There is no separate files for just this pathway. |
| Format | File | | Native Format (GENESIS format) | acc2.g | | GENESIS Format (Annotated version) | Anno_acc2.g |
| | 9 | CaM
Pathway No. 259 | CaMKII_noPKA_
model3
Accession No. 62 | Network | Molecule = 2
Enzyme = 0
Reaction = 5
| Molecule = 1
Enzyme = 0
Reaction = 0
| Hayer A, Bhalla US PLoS PLoS Comput Biol. 2005 Jul;1(2):137-54. Epub 2005 Jul 29. ( Peer-reviewed publication )/
2005-07-19 00:00:00 | | | #137Related Pathway:
14, 27, 81, 107, 122, 146, 160, 173, 203, 217, 236, 246, 265, 273, 283, 323, 340, 358, 368, 373, 379, 386, 392, 398
405, 411, 418, 423, 428, 434, 440, 446, 452, 458, 464, 470, 476, 482, 488, 494, 500, 506, 512, 518, 524, 530, 537, 543
549, 555, 561, 568, 573, 579, 585, 591, 597, 603, 609, 615, 621, 627, 633, 639, 645, 651, 657, 663, 669, 675, 681, 688
695, 701, 706, 712, 718, 724, 730, 736, 742, 748, 754, 760, 766, 772, 778, 784, 790, 796, 802, 808, 814, 820, 826, 832
838, 844, 850, 856, 862, 868, 874, 880, 886, 892, 898, 904, 910, 916, 924, 930, 936, 942, 948, 954, 961, 967, 973, 979
985, 991, 997, 1002, 1008, 1014, 1021, 1026, 1032, 1038, 1044, 1050, 1056, 1062, 1068, 1094 | | | This is the model of CaMKII bistability, model 3. It exhibits bistability in CaMKII activation due to autophosphorylation at the PSD and local saturation of PP1. This version of model 3 does not include the full PKA regulatory pathway, and instead has a predefined initial amount of active PKA. | | | This pathway is part of accession 62 and is completely specified in the file acc62.g.
There is no separate files for just this pathway. |
| | 10 | CaM
Pathway No. 265 | CaMKII_model3
Accession No. 63 | Network | Molecule = 2
Enzyme = 0
Reaction = 5
| Molecule = 1
Enzyme = 0
Reaction = 0
| Hayer A, Bhalla US PLoS Comput Biol. 2005 Jul;1(2):137-54. Epub 2005 Jul 29. ( Peer-reviewed publication )/
2005-07-19 00:00:00 | | | #137Related Pathway:
14, 27, 81, 107, 122, 146, 160, 173, 203, 217, 236, 246, 259, 273, 283, 323, 340, 358, 368, 373, 379, 386, 392, 398
405, 411, 418, 423, 428, 434, 440, 446, 452, 458, 464, 470, 476, 482, 488, 494, 500, 506, 512, 518, 524, 530, 537, 543
549, 555, 561, 568, 573, 579, 585, 591, 597, 603, 609, 615, 621, 627, 633, 639, 645, 651, 657, 663, 669, 675, 681, 688
695, 701, 706, 712, 718, 724, 730, 736, 742, 748, 754, 760, 766, 772, 778, 784, 790, 796, 802, 808, 814, 820, 826, 832
838, 844, 850, 856, 862, 868, 874, 880, 886, 892, 898, 904, 910, 916, 924, 930, 936, 942, 948, 954, 961, 967, 973, 979
985, 991, 997, 1002, 1008, 1014, 1021, 1026, 1032, 1038, 1044, 1050, 1056, 1062, 1068, 1094 | | | This is the complete model of CaMKII bistability, model 3. It exhibits bistability in CaMKII activation due to autophosphorylation at the PSD and local saturation of PP1. This version of model 3 includes PKA regulatory input. This has little effect on the deterministic calculations, but the PKA pathway introduces a lot of noise which causes a difference in stochastic runs. | | | This pathway is part of accession 63 and is completely specified in the file acc63.g.
There is no separate files for just this pathway. |
| | 11 | CaM
Pathway No. 203 | CaMKII_2003
Accession No. 49 | Network | Molecule = 4
Enzyme = 0
Reaction = 5
| Molecule = 1
Enzyme = 0
Reaction = 0
| Bhalla US. Biophys J. 2004 Aug;87(2):733-44. ( peer-reviewed publication )./
2003-04-28 00:00:00 | | | #137Related Pathway:
14, 27, 81, 107, 122, 146, 160, 173, 217, 236, 246, 259, 265, 273, 283, 323, 340, 358, 368, 373, 379, 386, 392, 398
405, 411, 418, 423, 428, 434, 440, 446, 452, 458, 464, 470, 476, 482, 488, 494, 500, 506, 512, 518, 524, 530, 537, 543
549, 555, 561, 568, 573, 579, 585, 591, 597, 603, 609, 615, 621, 627, 633, 639, 645, 651, 657, 663, 669, 675, 681, 688
695, 701, 706, 712, 718, 724, 730, 736, 742, 748, 754, 760, 766, 772, 778, 784, 790, 796, 802, 808, 814, 820, 826, 832
838, 844, 850, 856, 862, 868, 874, 880, 886, 892, 898, 904, 910, 916, 924, 930, 936, 942, 948, 954, 961, 967, 973, 979
985, 991, 997, 1002, 1008, 1014, 1021, 1026, 1032, 1038, 1044, 1050, 1056, 1062, 1068, 1094 | | | Model of regulation of CaMKII by Calcium, including parallel excitatory input from CaM and inhibitory input from PP1 as regulated by Calcineurin and PKA. Cell type: neuronal.
Bhalla US. Biophys J. 2004 Aug;87(2):733-44. | | | This pathway is part of accession 49 and is completely specified in the file acc49.g.
There is no separate files for just this pathway. |
| | 12 | CaM
Pathway No. 1094 | CaMKIII
Accession No. 90 | Network | Molecule = 4
Enzyme = 0
Reaction = 4
| Molecule = 1
Enzyme = 0
Reaction = 0
| Jain P, and Bhalla, U.S. PLoS Comput Biol. 2009 Feb;5(2). ( Peer-reviewed publication )/
2009-02-12 00:00:00 | | | #137Related Pathway:
14, 27, 81, 107, 122, 146, 160, 173, 203, 217, 236, 246, 259, 265, 273, 283, 323, 340, 358, 368, 373, 379, 386, 392
398, 405, 411, 418, 423, 428, 434, 440, 446, 452, 458, 464, 470, 476, 482, 488, 494, 500, 506, 512, 518, 524, 530, 537
543, 549, 555, 561, 568, 573, 579, 585, 591, 597, 603, 609, 615, 621, 627, 633, 639, 645, 651, 657, 663, 669, 675, 681
688, 695, 701, 706, 712, 718, 724, 730, 736, 742, 748, 754, 760, 766, 772, 778, 784, 790, 796, 802, 808, 814, 820, 826
832, 838, 844, 850, 856, 862, 868, 874, 880, 886, 892, 898, 904, 910, 916, 924, 930, 936, 942, 948, 954, 961, 967, 973
979, 985, 991, 997, 1002, 1008, 1014, 1021, 1026, 1032, 1038, 1044, 1050, 1056, 1062, 1068 | | | CaMKIII is activated by Ca2+ and inactivated by S6K. Since CaMKIII inhibits eEF2, the net effect of Ca2+ on elongation is inhibitory and of S6K is excitatory | | | This pathway is part of accession 90 and is completely specified in the file acc90.g.
There is no separate file for just this pathway. |
| Format | File | | Native Format (GENESIS format) | acc90.g |
| | 13 | CaM
Pathway No. 173 | CaMKII
Accession No. 33 | Network | Molecule = 5
Enzyme = 0
Reaction = 4
| Molecule = 1
Enzyme = 0
Reaction = 0
| William R. Holmes J Comput Neurosci. (2000) 8(1):65-85 ( peer-reviewed publication )/
2002-08-21 00:00:00 | | | #137Related Pathway:
14, 27, 81, 107, 122, 146, 160, 203, 217, 236, 246, 259, 265, 273, 283, 323, 340, 358, 368, 373, 379, 386, 392, 398
405, 411, 418, 423, 428, 434, 440, 446, 452, 458, 464, 470, 476, 482, 488, 494, 500, 506, 512, 518, 524, 530, 537, 543
549, 555, 561, 568, 573, 579, 585, 591, 597, 603, 609, 615, 621, 627, 633, 639, 645, 651, 657, 663, 669, 675, 681, 688
695, 701, 706, 712, 718, 724, 730, 736, 742, 748, 754, 760, 766, 772, 778, 784, 790, 796, 802, 808, 814, 820, 826, 832
838, 844, 850, 856, 862, 868, 874, 880, 886, 892, 898, 904, 910, 916, 924, 930, 936, 942, 948, 954, 961, 967, 973, 979
985, 991, 997, 1002, 1008, 1014, 1021, 1026, 1032, 1038, 1044, 1050, 1056, 1062, 1068, 1094 | | | This is a deterministic, point kinetics approximation to the dendritic spine CaMKII model described in William R. Holmes J Comput Neurosci. (2000) 8(1):65-85. Rates are the same but the responses differ somewhat because this model does not include the stochastic and diffusive calculations of the original. | | | | | 14 | CaM
Pathway No. 246 | AMPAR_traff_
model1
Accession No. 60 | Network | Molecule = 14
Enzyme = 0
Reaction = 11
| Molecule = 1
Enzyme = 0
Reaction = 0
| Hayer A, Bhalla US PLoS Comput Biol. 2005 Jul;1(2):137-54. Epub 2005 Jul 29. ( Peer-reviewed publication )/
2005-07-19 00:00:00 | | | #137Related Pathway:
14, 27, 81, 107, 122, 146, 160, 173, 203, 217, 236, 259, 265, 273, 283, 323, 340, 358, 368, 373, 379, 386, 392, 398
405, 411, 418, 423, 428, 434, 440, 446, 452, 458, 464, 470, 476, 482, 488, 494, 500, 506, 512, 518, 524, 530, 537, 543
549, 555, 561, 568, 573, 579, 585, 591, 597, 603, 609, 615, 621, 627, 633, 639, 645, 651, 657, 663, 669, 675, 681, 688
695, 701, 706, 712, 718, 724, 730, 736, 742, 748, 754, 760, 766, 772, 778, 784, 790, 796, 802, 808, 814, 820, 826, 832
838, 844, 850, 856, 862, 868, 874, 880, 886, 892, 898, 904, 910, 916, 924, 930, 936, 942, 948, 954, 961, 967, 973, 979
985, 991, 997, 1002, 1008, 1014, 1021, 1026, 1032, 1038, 1044, 1050, 1056, 1062, 1068, 1094 | | | This is the basic model of AMPAR trafficking bistability. It is based on Hayer and Bhalla, PLoS Comput. Biol. 2005. It includes the degradation and turnover of AMPARs. The CaMKII portion of the model is not bistable. | | | This pathway is part of accession 60 and is completely specified in the file acc60.g.
There is no separate files for just this pathway. |
| | 15 | CaM
Pathway No. 236 | AMPAR_traff_
model0
Accession No. 59 | Network | Molecule = 14
Enzyme = 0
Reaction = 11
| Molecule = 1
Enzyme = 0
Reaction = 0
| Hayer A, Bhalla US PLoS Comput Biol. 2005 Jul;1(2):137-54. Epub 2005 Jul 29. ( Peer-reviewed publication )/
2005-07-19 00:00:00 | | | #137Related Pathway:
14, 27, 81, 107, 122, 146, 160, 173, 203, 217, 246, 259, 265, 273, 283, 323, 340, 358, 368, 373, 379, 386, 392, 398
405, 411, 418, 423, 428, 434, 440, 446, 452, 458, 464, 470, 476, 482, 488, 494, 500, 506, 512, 518, 524, 530, 537, 543
549, 555, 561, 568, 573, 579, 585, 591, 597, 603, 609, 615, 621, 627, 633, 639, 645, 651, 657, 663, 669, 675, 681, 688
695, 701, 706, 712, 718, 724, 730, 736, 742, 748, 754, 760, 766, 772, 778, 784, 790, 796, 802, 808, 814, 820, 826, 832
838, 844, 850, 856, 862, 868, 874, 880, 886, 892, 898, 904, 910, 916, 924, 930, 936, 942, 948, 954, 961, 967, 973, 979
985, 991, 997, 1002, 1008, 1014, 1021, 1026, 1032, 1038, 1044, 1050, 1056, 1062, 1068, 1094 | | | This is model 0 from Hayer and Bhalla, PLoS Comput Biol 2005. It has a bistable model of AMPAR traffick, plus a
non-bistable model of CaMKII. This differs from the reference model (model 1) in that model0 lacks degradation and turno
ver reactions for AMPAR. | | | This pathway is part of accession 59 and is completely specified in the file acc59.g.
There is no separate files for just this pathway. |
| | 16 | CaM
Pathway No. 283 | AMPAR_CaMKII_
weak_coupling
Accession No. 65 | Network | Molecule = 8
Enzyme = 0
Reaction = 9
| Molecule = 1
Enzyme = 0
Reaction = 0
| Hayer A, Bhalla US PLoS Comput Biol. 2005 Jul;1(2):137-54. Epub 2005 Jul 29. ( Peer-reviewed publication )/
2005-07-21 00:00:00 | | | #137Related Pathway:
14, 27, 81, 107, 122, 146, 160, 173, 203, 217, 236, 246, 259, 265, 273, 323, 340, 358, 368, 373, 379, 386, 392, 398
405, 411, 418, 423, 428, 434, 440, 446, 452, 458, 464, 470, 476, 482, 488, 494, 500, 506, 512, 518, 524, 530, 537, 543
549, 555, 561, 568, 573, 579, 585, 591, 597, 603, 609, 615, 621, 627, 633, 639, 645, 651, 657, 663, 669, 675, 681, 688
695, 701, 706, 712, 718, 724, 730, 736, 742, 748, 754, 760, 766, 772, 778, 784, 790, 796, 802, 808, 814, 820, 826, 832
838, 844, 850, 856, 862, 868, 874, 880, 886, 892, 898, 904, 910, 916, 924, 930, 936, 942, 948, 954, 961, 967, 973, 979
985, 991, 997, 1002, 1008, 1014, 1021, 1026, 1032, 1038, 1044, 1050, 1056, 1062, 1068, 1094 | | | This is a model of weak coupling between the AMPAR traffikcing bistability, and the CaMKII autophosphorylation bistability. In this model, there are three stable states: Both off, AMPAR on, or both on. The fourth possible state: CaMKII on but AMPAR off, is not truly stable, since over the course of hours the AMPAR also turns on. | | | This pathway is part of accession 65 and is completely specified in the file acc65.g.
There is no separate files for just this pathway. |
| | 17 | CaM
Pathway No. 273 | AMPAR_CaMKII_
strong_coupling
Accession No. 64 | Network | Molecule = 8
Enzyme = 0
Reaction = 9
| Molecule = 1
Enzyme = 0
Reaction = 0
| Hayer A, Bhalla US PLoS Comput Biol. 2005 Jul;1(2):137-54. Epub 2005 Jul 29. ( Peer-reviewed publication )/
2005-07-19 00:00:00 | | | #137Related Pathway:
14, 27, 81, 107, 122, 146, 160, 173, 203, 217, 236, 246, 259, 265, 283, 323, 340, 358, 368, 373, 379, 386, 392, 398
405, 411, 418, 423, 428, 434, 440, 446, 452, 458, 464, 470, 476, 482, 488, 494, 500, 506, 512, 518, 524, 530, 537, 543
549, 555, 561, 568, 573, 579, 585, 591, 597, 603, 609, 615, 621, 627, 633, 639, 645, 651, 657, 663, 669, 675, 681, 688
695, 701, 706, 712, 718, 724, 730, 736, 742, 748, 754, 760, 766, 772, 778, 784, 790, 796, 802, 808, 814, 820, 826, 832
838, 844, 850, 856, 862, 868, 874, 880, 886, 892, 898, 904, 910, 916, 924, 930, 936, 942, 948, 954, 961, 967, 973, 979
985, 991, 997, 1002, 1008, 1014, 1021, 1026, 1032, 1038, 1044, 1050, 1056, 1062, 1068, 1094 | | | This is a model of tight coupling between the AMPAR trafficking bistability, and the CaMKII autophosphorylation bistability. In this model, the CaMKII activity is self sustaining only when AMPAR is turned on. Further, CaMKII turns on when AMPAR is turned on. | | | This pathway is part of accession 64 and is completely specified in the file acc64.g.
There is no separate files for just this pathway. |
| | 18 | CaM
Pathway No. 924 | Ajay_Bhalla_
2007_ReacDiff3
Accession No. 84 | Network | Molecule = 4
Enzyme = 0
Reaction = 3
| Molecule = 1
Enzyme = 0
Reaction = 0
| Ajay_Bhalla_bistable_model. HFSP Journal. 2007 May;1(1):1-87/
2006-12-08 00:00:00 | | | #137Related Pathway:
14, 27, 81, 107, 122, 146, 160, 173, 203, 217, 236, 246, 259, 265, 273, 283, 323, 340, 358, 368, 373, 379, 386, 392
398, 405, 411, 418, 423, 428, 434, 440, 446, 452, 458, 464, 470, 476, 482, 488, 494, 500, 506, 512, 518, 524, 530, 537
543, 549, 555, 561, 568, 573, 579, 585, 591, 597, 603, 609, 615, 621, 627, 633, 639, 645, 651, 657, 663, 669, 675, 681
688, 695, 701, 706, 712, 718, 724, 730, 736, 742, 748, 754, 760, 766, 772, 778, 784, 790, 796, 802, 808, 814, 820, 826
832, 838, 844, 850, 856, 862, 868, 874, 880, 886, 892, 898, 904, 910, 916, 930, 936, 942, 948, 954, 961, 967, 973, 979
985, 991, 997, 1002, 1008, 1014, 1021, 1026, 1032, 1038, 1044, 1050, 1056, 1062, 1068, 1094 | | | This is a 25-compartment reaction-diffusion version of the Ajay_Bhalla_2007_bistable model. The original single-compartment model is repeated 25 times.
In addition, a subset (33 out of 50) molecules can diffuse between compartments. Diffusion is implemented as a reaction between corresponding molecules in neighboring compartments. Here D = 1e-13 m^2/sec (i.e., 0.1 micron^2/sec ) so the kf and kb of this reaction for these 10 micron compartments are both 0.001/sec.
The basal calcium level in this model is held at 95 nM which is rather close to threshold for the flip to the active state. This is necessary to sustain active propagation of activation.
The stimulus file bis6-propgn_D1e-13_FigEF which was used for the model to replicate Figure 4E and 4F from the paper. | | | This pathway is part of accession 84 and is completely specified in the file acc84.g.
There is no separate for just this pathway. |
| | 19 | CaM
Pathway No. 930 | Ajay_Bhalla_
2007_ReacDiff3
Accession No. 84 | Network | Molecule = 4
Enzyme = 0
Reaction = 3
| Molecule = 1
Enzyme = 0
Reaction = 0
| Ajay_Bhalla_bistable_model. HFSP Journal. 2007 May;1(1):1-87/
2006-12-08 00:00:00 | | | #137Related Pathway:
14, 27, 81, 107, 122, 146, 160, 173, 203, 217, 236, 246, 259, 265, 273, 283, 323, 340, 358, 368, 373, 379, 386, 392
398, 405, 411, 418, 423, 428, 434, 440, 446, 452, 458, 464, 470, 476, 482, 488, 494, 500, 506, 512, 518, 524, 530, 537
543, 549, 555, 561, 568, 573, 579, 585, 591, 597, 603, 609, 615, 621, 627, 633, 639, 645, 651, 657, 663, 669, 675, 681
688, 695, 701, 706, 712, 718, 724, 730, 736, 742, 748, 754, 760, 766, 772, 778, 784, 790, 796, 802, 808, 814, 820, 826
832, 838, 844, 850, 856, 862, 868, 874, 880, 886, 892, 898, 904, 910, 916, 924, 936, 942, 948, 954, 961, 967, 973, 979
985, 991, 997, 1002, 1008, 1014, 1021, 1026, 1032, 1038, 1044, 1050, 1056, 1062, 1068, 1094 | | | This is a 25-compartment reaction-diffusion version of the Ajay_Bhalla_2007_bistable model. The original single-compartment model is repeated 25 times.
In addition, a subset (33 out of 50) molecules can diffuse between compartments. Diffusion is implemented as a reaction between corresponding molecules in neighboring compartments. Here D = 1e-13 m^2/sec (i.e., 0.1 micron^2/sec ) so the kf and kb of this reaction for these 10 micron compartments are both 0.001/sec.
The basal calcium level in this model is held at 95 nM which is rather close to threshold for the flip to the active state. This is necessary to sustain active propagation of activation.
The stimulus file bis6-propgn_D1e-13_FigEF which was used for the model to replicate Figure 4E and 4F from the paper. | | | This pathway is part of accession 84 and is completely specified in the file acc84.g.
There is no separate for just this pathway. |
| | 20 | CaM
Pathway No. 936 | Ajay_Bhalla_
2007_ReacDiff3
Accession No. 84 | Network | Molecule = 4
Enzyme = 0
Reaction = 3
| Molecule = 1
Enzyme = 0
Reaction = 0
| Ajay_Bhalla_bistable_model. HFSP Journal. 2007 May;1(1):1-87/
2006-12-08 00:00:00 | | | #137Related Pathway:
14, 27, 81, 107, 122, 146, 160, 173, 203, 217, 236, 246, 259, 265, 273, 283, 323, 340, 358, 368, 373, 379, 386, 392
398, 405, 411, 418, 423, 428, 434, 440, 446, 452, 458, 464, 470, 476, 482, 488, 494, 500, 506, 512, 518, 524, 530, 537
543, 549, 555, 561, 568, 573, 579, 585, 591, 597, 603, 609, 615, 621, 627, 633, 639, 645, 651, 657, 663, 669, 675, 681
688, 695, 701, 706, 712, 718, 724, 730, 736, 742, 748, 754, 760, 766, 772, 778, 784, 790, 796, 802, 808, 814, 820, 826
832, 838, 844, 850, 856, 862, 868, 874, 880, 886, 892, 898, 904, 910, 916, 924, 930, 942, 948, 954, 961, 967, 973, 979
985, 991, 997, 1002, 1008, 1014, 1021, 1026, 1032, 1038, 1044, 1050, 1056, 1062, 1068, 1094 | | | This is a 25-compartment reaction-diffusion version of the Ajay_Bhalla_2007_bistable model. The original single-compartment model is repeated 25 times.
In addition, a subset (33 out of 50) molecules can diffuse between compartments. Diffusion is implemented as a reaction between corresponding molecules in neighboring compartments. Here D = 1e-13 m^2/sec (i.e., 0.1 micron^2/sec ) so the kf and kb of this reaction for these 10 micron compartments are both 0.001/sec.
The basal calcium level in this model is held at 95 nM which is rather close to threshold for the flip to the active state. This is necessary to sustain active propagation of activation.
The stimulus file bis6-propgn_D1e-13_FigEF which was used for the model to replicate Figure 4E and 4F from the paper. | | | This pathway is part of accession 84 and is completely specified in the file acc84.g.
There is no separate for just this pathway. |
|
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
This Copyright is applied to ensure that the contents of this database remain freely available. Please see FAQ for details. |
|
