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Pathway List for cam

Default ordering is done according to Pathway Name.Table header can be used for changing the default ordering.
indicates that ordering is done according to ascending or descending order.
Entries are color tagged depending on Network  or Pathway 
  Pathway Name
Pathway No.
Accession Name
Accession No.
Accession
Type
Pathway statisticscam statisticsSource
Entry Date
1 CaM
Pathway No. 14
 fig3_CaMKII

Accession No. 2
NetworkMolecule = 4
Enzyme   = 0
Reaction  = 5
Molecule = 1
Enzyme   = 0
Reaction  = 0
Bhalla US and Iyengar R. Science (1999) 283(5400):381-7. ( peer-reviewed publication )/
2001-11-07
   Related Pathway: 
2781107122146160173203217236246259265273283323340358368373379386392
398405411418423428434440446452458464470476482488494500506512518524530537
543549555561568573579585591597603609615621627633639645651657663669675681
688695701706712718724730736742748754760766772778784790796802808814820826
832838844850856862868874880886892898904910916924930936942948954961967973
97998599199710021008101410211026103210381044105010561062106810941109
    This is the model file for figure 3 from Bhalla US and Iyengar R. Science (1999) 283(5400):381-7. It is a model of the Ca activation of CaMKII and other CaM-activated enzymes. It includes the regulatory phosphatases PP1 and PP2B (Calcineurin) acting on CaMKII and also includes CaM-activated adenylyl cyclase and PKA in the synapse.
Demonstration script files for generating the figures in the paper, including figure 3, are available here.
   
This pathway is part of accession 2 and is completely specified in the file acc2.g.
There is no separate files for just this pathway.
FormatFile
Native Format (GENESIS format)    acc2.g   
GENESIS Format (Annotated version)    Anno_acc2.g   
2 CaM
Pathway No. 27
 fig4_synapse

Accession No. 3
NetworkMolecule = 4
Enzyme   = 0
Reaction  = 5
Molecule = 1
Enzyme   = 0
Reaction  = 0
Bhalla US and Iyengar R. Science (1999) 283(5400):381-7. ( peer-reviewed publication )/
2001-11-07
   Related Pathway: 
1481107122146160173203217236246259265273283323340358368373379386392
398405411418423428434440446452458464470476482488494500506512518524530537
543549555561568573579585591597603609615621627633639645651657663669675681
688695701706712718724730736742748754760766772778784790796802808814820826
832838844850856862868874880886892898904910916924930936942948954961967973
97998599199710021008101410211026103210381044105010561062106810941109
    This is the composite model of 4 kinases: PKC, MAPK, PKA and CaMKII and numerous regulatory pathways involved in synaptic signaling. From Bhalla US and Iyengar R. Science (1999) 283(5400):381-7.This model comes from figure 4 of that paper.
Demonstration script files for generating the figures in the paper, including figure 4, are available here.
   
This pathway is part of accession 3 and is completely specified in the file acc3.g.
There is no separate files for just this pathway.
FormatFile
Native Format (GENESIS format)    acc3.g   
GENESIS Format (Annotated version)    Anno_acc3.g   
3 CaM
Pathway No. 81
 Synaptic_
Network

Accession No. 16
NetworkMolecule = 4
Enzyme   = 0
Reaction  = 5
Molecule = 1
Enzyme   = 0
Reaction  = 0
Bhalla US and Iyengar R. Science (1999) 283(5400):381-7. ( peer-reviewed publication )/
2001-12-12
   Related Pathway: 
1427107122146160173203217236246259265273283323340358368373379386392
398405411418423428434440446452458464470476482488494500506512518524530537
543549555561568573579585591597603609615621627633639645651657663669675681
688695701706712718724730736742748754760766772778784790796802808814820826
832838844850856862868874880886892898904910916924930936942948954961967973
97998599199710021008101410211026103210381044105010561062106810941109
    This is the basic Ca-binding-to-CaM model with the addition of neurogranin as a CaM se questering molecule. Main data sources are Forsen et al 1986 Calcium and Cell funciton VI 113_ 157 Drabikowski and Brzeska 1982 JBC 257(19):11584-11590 Martin et al 1985 Eur J Biochem 151(3) :543-550 Stemmer and Klee 1994 Biochem 33:6859-6866 Data is pretty thorough. The Neurogranin in fo is from several sources esp Huang et al 1993 ABB 305(2):570-580 Gerendasy et al 1994 JBC 269 (35) 22420-22426 is not very quantitative
   
This pathway is part of accession 16 and is completely specified in the file acc16.g.
There is no separate files for just this pathway.
FormatFile
Native Format (GENESIS format)    acc16.g   
GENESIS Format (Annotated version)    Anno_acc16.g   
4 CaM
Pathway No. 107
 NonOsc_Ca_
IP3metabolism

Accession No. 23
NetworkMolecule = 4
Enzyme   = 0
Reaction  = 3
Molecule = 1
Enzyme   = 0
Reaction  = 0
Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316. ( peer-reviewed publication )/
2002-01-07
   Related Pathway: 
142781122146160173203217236246259265273283323340358368373379386392398
405411418423428434440446452458464470476482488494500506512518524530537543
549555561568573579585591597603609615621627633639645651657663669675681688
695701706712718724730736742748754760766772778784790796802808814820826832
838844850856862868874880886892898904910916924930936942948954961967973979
98599199710021008101410211026103210381044105010561062106810941109
    This is the basic Ca-binding-to-CaM model. Main data sources are Forsen S.et al (1986) in Calcium and Cell function, volume 6 (Cheung, W. Y., ed.) pp.112-157, Academic Press, New York and Drabikowski W. et al, J Biol Chem. 1982 Oct 10;257(19):11584-90 and Martin SR et al Eur J Biochem. 1985 Sep 16;151(3):543-50 and Stemmer PM, Klee CB Biochemistry. 1994 Jun 7;33(22):6859-66 Data is pretty thorough.
   
This pathway is part of accession 23 and is completely specified in the file acc23.g.
There is no separate files for just this pathway.
FormatFile
Native Format (GENESIS format)    acc23.g   
GENESIS Format (Annotated version)    Anno_acc23.g   
5 CaM
Pathway No. 122
 Osc_Ca_
IP3metabolism

Accession No. 24
NetworkMolecule = 4
Enzyme   = 0
Reaction  = 3
Molecule = 1
Enzyme   = 0
Reaction  = 0
Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316. ( peer-reviewed publication )/
2002-01-08
   Related Pathway: 
142781107146160173203217236246259265273283323340358368373379386392398
405411418423428434440446452458464470476482488494500506512518524530537543
549555561568573579585591597603609615621627633639645651657663669675681688
695701706712718724730736742748754760766772778784790796802808814820826832
838844850856862868874880886892898904910916924930936942948954961967973979
98599199710021008101410211026103210381044105010561062106810941109
    This is the basic Ca-binding-to-CaM model. Main data sources are Forsen et al 1986 Calcium and Cell funciton VI 113_157 Drabikowski and Brzeska 1982 JBC 257(19):11584-11590 Martin et al 1985 Eur J Biochem 151(3):543-550 Stemmer and Klee 1994 Biochem 33:6859-6866 Data is pretty thorough.
   
This pathway is part of accession 24 and is completely specified in the file acc24.g.
There is no separate files for just this pathway.
FormatFile
Native Format (GENESIS format)    acc24.g   
GENESIS Format (Annotated version)    Anno_acc24.g   
6 CaM
Pathway No. 146
 NonOsc_Ca_
IP3metabolism

Accession No. 31
NetworkMolecule = 4
Enzyme   = 0
Reaction  = 3
Molecule = 1
Enzyme   = 0
Reaction  = 0
Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316. ( peer-reviewed publication )/
2002-04-03
   Related Pathway: 
142781107122160173203217236246259265273283323340358368373379386392398
405411418423428434440446452458464470476482488494500506512518524530537543
549555561568573579585591597603609615621627633639645651657663669675681688
695701706712718724730736742748754760766772778784790796802808814820826832
838844850856862868874880886892898904910916924930936942948954961967973979
98599199710021008101410211026103210381044105010561062106810941109
    This is the basic Ca-binding-to-CaM model. Main data sources are Forsen et al 1986 Calcium and Cell funciton VI 113_157 Drabikowski and Brzeska 1982 JBC 257(19):11584-11590 Martin et al 1985 Eur J Biochem 151(3):543-550 Stemmer and Klee 1994 Biochem 33:6859-6866 Data is pretty thorough.
   
This pathway is part of accession 31 and is completely specified in the file acc31.g.
There is no separate files for just this pathway.
FormatFile
Native Format (GENESIS format)    acc31.g   
GENESIS Format (Annotated version)    Anno_acc31.g   
7 CaM
Pathway No. 160
 Osc_Ca_
IP3metabolism

Accession No. 32
NetworkMolecule = 4
Enzyme   = 0
Reaction  = 3
Molecule = 1
Enzyme   = 0
Reaction  = 0
Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316. ( peer-reviewed publication )/
2002-04-03
   Related Pathway: 
142781107122146173203217236246259265273283323340358368373379386392398
405411418423428434440446452458464470476482488494500506512518524530537543
549555561568573579585591597603609615621627633639645651657663669675681688
695701706712718724730736742748754760766772778784790796802808814820826832
838844850856862868874880886892898904910916924930936942948954961967973979
98599199710021008101410211026103210381044105010561062106810941109
    This is the basic Ca-binding-to-CaM model. Main data sources are Forsen et al 1986 Calcium and Cell funciton VI 113_157 Drabikowski and Brzeska 1982 JBC 257(19):11584-11590 Martin et al 1985 Eur J Biochem 151(3):543-550 Stemmer and Klee 1994 Biochem 33:6859-6866 Data is pretty thorough.
   
This pathway is part of accession 32 and is completely specified in the file acc32.g.
There is no separate files for just this pathway.
FormatFile
Native Format (GENESIS format)    acc32.g   
GENESIS Format (Annotated version)    Anno_acc32.g   
8 CaM
Pathway No. 173
 CaMKII

Accession No. 33
NetworkMolecule = 5
Enzyme   = 0
Reaction  = 4
Molecule = 1
Enzyme   = 0
Reaction  = 0
William R. Holmes J Comput Neurosci. (2000) 8(1):65-85 ( peer-reviewed publication )/
2002-08-21
   Related Pathway: 
142781107122146160203217236246259265273283323340358368373379386392398
405411418423428434440446452458464470476482488494500506512518524530537543
549555561568573579585591597603609615621627633639645651657663669675681688
695701706712718724730736742748754760766772778784790796802808814820826832
838844850856862868874880886892898904910916924930936942948954961967973979
98599199710021008101410211026103210381044105010561062106810941109
    This is a deterministic, point kinetics approximation to the dendritic spine CaMKII model described in William R. Holmes J Comput Neurosci. (2000) 8(1):65-85. Rates are the same but the responses differ somewhat because this model does not include the stochastic and diffusive calculations of the original.
   
FormatFile
Native Format (GENESIS format)    path173.g   
GENESIS Format (Annotated version)    Anno_path173.g   
9 CaM
Pathway No. 203
 CaMKII_2003

Accession No. 49
NetworkMolecule = 4
Enzyme   = 0
Reaction  = 5
Molecule = 1
Enzyme   = 0
Reaction  = 0
Bhalla US. Biophys J. 2004 Aug;87(2):733-44. ( peer-reviewed publication )./
2003-04-28
   Related Pathway: 
142781107122146160173217236246259265273283323340358368373379386392398
405411418423428434440446452458464470476482488494500506512518524530537543
549555561568573579585591597603609615621627633639645651657663669675681688
695701706712718724730736742748754760766772778784790796802808814820826832
838844850856862868874880886892898904910916924930936942948954961967973979
98599199710021008101410211026103210381044105010561062106810941109
    Model of regulation of CaMKII by Calcium, including parallel excitatory input from CaM and inhibitory input from PP1 as regulated by Calcineurin and PKA. Cell type: neuronal.
Bhalla US. Biophys J. 2004 Aug;87(2):733-44.
   
This pathway is part of accession 49 and is completely specified in the file acc49.g.
There is no separate files for just this pathway.
FormatFile
Native Format (GENESIS format)    acc49.g   
GENESIS Format (Annotated version)    Anno_acc49.g   
MATLAB format    acc49.m   
SBML format    acc49.xml   
10 CaM
Pathway No. 217
 MAPK_network_
2003

Accession No. 50
NetworkMolecule = 4
Enzyme   = 0
Reaction  = 5
Molecule = 1
Enzyme   = 0
Reaction  = 0
Bhalla US Biophys J. 2004 Aug;87(2):745-53. ( peer-reviewed publication )/
2003-04-28
   Related Pathway: 
142781107122146160173203236246259265273283323340358368373379386392398
405411418423428434440446452458464470476482488494500506512518524530537543
549555561568573579585591597603609615621627633639645651657663669675681688
695701706712718724730736742748754760766772778784790796802808814820826832
838844850856862868874880886892898904910916924930936942948954961967973979
98599199710021008101410211026103210381044105010561062106810941109
    This is a network model of many pathways present at the neuronal synapse. The network has properties of temporal tuning as well as steady-state computational properties. In its default form the network is bistable.Bhalla US Biophys J. 2004 Aug;87(2):745-53
   
FormatFile
Native Format (GENESIS format)    path217.g   
GENESIS Format (Annotated version)    Anno_path217.g   
MATLAB format    path217.m   
11 CaM
Pathway No. 236
 AMPAR_traff_
model0

Accession No. 59
NetworkMolecule = 14
Enzyme   = 0
Reaction  = 11
Molecule = 1
Enzyme   = 0
Reaction  = 0
Hayer A, Bhalla US PLoS Comput Biol. 2005 Jul;1(2):137-54. Epub 2005 Jul 29. ( Peer-reviewed publication )/
2005-07-19
   Related Pathway: 
142781107122146160173203217246259265273283323340358368373379386392398
405411418423428434440446452458464470476482488494500506512518524530537543
549555561568573579585591597603609615621627633639645651657663669675681688
695701706712718724730736742748754760766772778784790796802808814820826832
838844850856862868874880886892898904910916924930936942948954961967973979
98599199710021008101410211026103210381044105010561062106810941109
    This is model 0 from Hayer and Bhalla, PLoS Comput Biol 2005. It has a bistable model of AMPAR traffick, plus a non-bistable model of CaMKII. This differs from the reference model (model 1) in that model0 lacks degradation and turno ver reactions for AMPAR.
   
This pathway is part of accession 59 and is completely specified in the file acc59.g.
There is no separate files for just this pathway.
FormatFile
Native Format (GENESIS format)    acc59.g   
MATLAB format    acc59.m   
SBML format    acc59.xml   
12 CaM
Pathway No. 246
 AMPAR_traff_
model1

Accession No. 60
NetworkMolecule = 14
Enzyme   = 0
Reaction  = 11
Molecule = 1
Enzyme   = 0
Reaction  = 0
Hayer A, Bhalla US PLoS Comput Biol. 2005 Jul;1(2):137-54. Epub 2005 Jul 29. ( Peer-reviewed publication )/
2005-07-19
   Related Pathway: 
142781107122146160173203217236259265273283323340358368373379386392398
405411418423428434440446452458464470476482488494500506512518524530537543
549555561568573579585591597603609615621627633639645651657663669675681688
695701706712718724730736742748754760766772778784790796802808814820826832
838844850856862868874880886892898904910916924930936942948954961967973979
98599199710021008101410211026103210381044105010561062106810941109
    This is the basic model of AMPAR trafficking bistability. It is based on Hayer and Bhalla, PLoS Comput. Biol. 2005. It includes the degradation and turnover of AMPARs. The CaMKII portion of the model is not bistable.
   
This pathway is part of accession 60 and is completely specified in the file acc60.g.
There is no separate files for just this pathway.
FormatFile
Native Format (GENESIS format)    acc60.g   
MATLAB format    acc60.m   
SBML format    acc60.xml   
13 CaM
Pathway No. 259
 CaMKII_noPKA_
model3

Accession No. 62
NetworkMolecule = 2
Enzyme   = 0
Reaction  = 5
Molecule = 1
Enzyme   = 0
Reaction  = 0
Hayer A, Bhalla US PLoS PLoS Comput Biol. 2005 Jul;1(2):137-54. Epub 2005 Jul 29. ( Peer-reviewed publication )/
2005-07-19
   Related Pathway: 
142781107122146160173203217236246265273283323340358368373379386392398
405411418423428434440446452458464470476482488494500506512518524530537543
549555561568573579585591597603609615621627633639645651657663669675681688
695701706712718724730736742748754760766772778784790796802808814820826832
838844850856862868874880886892898904910916924930936942948954961967973979
98599199710021008101410211026103210381044105010561062106810941109
    This is the model of CaMKII bistability, model 3. It exhibits bistability in CaMKII activation due to autophosphorylation at the PSD and local saturation of PP1. This version of model 3 does not include the full PKA regulatory pathway, and instead has a predefined initial amount of active PKA.
   
This pathway is part of accession 62 and is completely specified in the file acc62.g.
There is no separate files for just this pathway.
FormatFile
Native Format (GENESIS format)    acc62.g   
MATLAB format    acc62.m   
SBML format    acc62.xml   
14 CaM
Pathway No. 265
 CaMKII_model3

Accession No. 63
NetworkMolecule = 2
Enzyme   = 0
Reaction  = 5
Molecule = 1
Enzyme   = 0
Reaction  = 0
Hayer A, Bhalla US PLoS Comput Biol. 2005 Jul;1(2):137-54. Epub 2005 Jul 29. ( Peer-reviewed publication )/
2005-07-19
   Related Pathway: 
142781107122146160173203217236246259273283323340358368373379386392398
405411418423428434440446452458464470476482488494500506512518524530537543
549555561568573579585591597603609615621627633639645651657663669675681688
695701706712718724730736742748754760766772778784790796802808814820826832
838844850856862868874880886892898904910916924930936942948954961967973979
98599199710021008101410211026103210381044105010561062106810941109
    This is the complete model of CaMKII bistability, model 3. It exhibits bistability in CaMKII activation due to autophosphorylation at the PSD and local saturation of PP1. This version of model 3 includes PKA regulatory input. This has little effect on the deterministic calculations, but the PKA pathway introduces a lot of noise which causes a difference in stochastic runs.
   
This pathway is part of accession 63 and is completely specified in the file acc63.g.
There is no separate files for just this pathway.
FormatFile
Native Format (GENESIS format)    acc63.g   
MATLAB format    acc63.m   
SBML format    acc63.xml   
15 CaM
Pathway No. 273
 AMPAR_CaMKII_
strong_coupling

Accession No. 64
NetworkMolecule = 8
Enzyme   = 0
Reaction  = 9
Molecule = 1
Enzyme   = 0
Reaction  = 0
Hayer A, Bhalla US PLoS Comput Biol. 2005 Jul;1(2):137-54. Epub 2005 Jul 29. ( Peer-reviewed publication )/
2005-07-19
   Related Pathway: 
142781107122146160173203217236246259265283323340358368373379386392398
405411418423428434440446452458464470476482488494500506512518524530537543
549555561568573579585591597603609615621627633639645651657663669675681688
695701706712718724730736742748754760766772778784790796802808814820826832
838844850856862868874880886892898904910916924930936942948954961967973979
98599199710021008101410211026103210381044105010561062106810941109
    This is a model of tight coupling between the AMPAR trafficking bistability, and the CaMKII autophosphorylation bistability. In this model, the CaMKII activity is self sustaining only when AMPAR is turned on. Further, CaMKII turns on when AMPAR is turned on.
   
This pathway is part of accession 64 and is completely specified in the file acc64.g.
There is no separate files for just this pathway.
FormatFile
Native Format (GENESIS format)    acc64.g   
MATLAB format    acc64.m   
SBML format    acc64.xml   
16 CaM
Pathway No. 283
 AMPAR_CaMKII_
weak_coupling

Accession No. 65
NetworkMolecule = 8
Enzyme   = 0
Reaction  = 9
Molecule = 1
Enzyme   = 0
Reaction  = 0
Hayer A, Bhalla US PLoS Comput Biol. 2005 Jul;1(2):137-54. Epub 2005 Jul 29. ( Peer-reviewed publication )/
2005-07-21
   Related Pathway: 
142781107122146160173203217236246259265273323340358368373379386392398
405411418423428434440446452458464470476482488494500506512518524530537543
549555561568573579585591597603609615621627633639645651657663669675681688
695701706712718724730736742748754760766772778784790796802808814820826832
838844850856862868874880886892898904910916924930936942948954961967973979
98599199710021008101410211026103210381044105010561062106810941109
    This is a model of weak coupling between the AMPAR traffikcing bistability, and the CaMKII autophosphorylation bistability. In this model, there are three stable states: Both off, AMPAR on, or both on. The fourth possible state: CaMKII on but AMPAR off, is not truly stable, since over the course of hours the AMPAR also turns on.
   
This pathway is part of accession 65 and is completely specified in the file acc65.g.
There is no separate files for just this pathway.
FormatFile
Native Format (GENESIS format)    acc65.g   
MATLAB format    acc65.m   
SBML format    acc65.xml   
17 CaM
Pathway No. 323
 Ajay_Bhalla_
2004_PKM_Tuning

Accession No. 76
NetworkMolecule = 4
Enzyme   = 0
Reaction  = 5
Molecule = 1
Enzyme   = 0
Reaction  = 0
Ajay SM, Bhalla US. Eur J Neurosci. 2004 Nov;20(10):2671-80. ( Peer-reviewed publication )/
2006-12-12
   Related Pathway: 
142781107122146160173203217236246259265273283340358368373379386392398
405411418423428434440446452458464470476482488494500506512518524530537543
549555561568573579585591597603609615621627633639645651657663669675681688
695701706712718724730736742748754760766772778784790796802808814820826832
838844850856862868874880886892898904910916924930936942948954961967973979
98599199710021008101410211026103210381044105010561062106810941109
    This model is taken from the Ajay SM, Bhalla US. Eur J Neurosci. 2004 Nov;20(10):2671-80. This is the reference feedforward model from Figure 8a.
   
This pathway is part of accession 76 and is completely specified in the file acc76.g.
There is no separate files for just this pathway.
FormatFile
Native Format (GENESIS format)    acc76.g   
MATLAB format    acc76.m   
SBML format    acc76.xml   
18 CaM
Pathway No. 340
 Ajay_Bhalla_
2004_PKM_MKP3_
Tuning

Accession No. 77
NetworkMolecule = 4
Enzyme   = 0
Reaction  = 5
Molecule = 1
Enzyme   = 0
Reaction  = 0
Ajay SM, Bhalla US. Eur J Neurosci. 2004 Nov;20(10):2671-80 ( Peer-reviewed publication )/
2006-12-12
   Related Pathway: 
142781107122146160173203217236246259265273283323358368373379386392398
405411418423428434440446452458464470476482488494500506512518524530537543
549555561568573579585591597603609615621627633639645651657663669675681688
695701706712718724730736742748754760766772778784790796802808814820826832
838844850856862868874880886892898904910916924930936942948954961967973979
98599199710021008101410211026103210381044105010561062106810941109
    This model is based on Ajay SM, Bhalla US. Eur J Neurosci. 2004 Nov;20(10):2671-80. This is the feedforward model with MPK3 from figure 8a.
   
This pathway is part of accession 77 and is completely specified in the file acc77.g.
There is no separate files for just this pathway.
FormatFile
Native Format (GENESIS format)    acc77.g   
MATLAB format    acc77.m   
SBML format    acc77.xml   
19 CaM
Pathway No. 358
 Ajay_Bhalla_
2004_Feedback_
Tuning

Accession No. 78
NetworkMolecule = 4
Enzyme   = 0
Reaction  = 5
Molecule = 1
Enzyme   = 0
Reaction  = 0
Ajay SM, Bhalla US. Eur J Neurosci. 2004 Nov;20(10):2671-80. ( Peer-reviewed publication )/
2006-12-12
   Related Pathway: 
142781107122146160173203217236246259265273283323340368373379386392398
405411418423428434440446452458464470476482488494500506512518524530537543
549555561568573579585591597603609615621627633639645651657663669675681688
695701706712718724730736742748754760766772778784790796802808814820826832
838844850856862868874880886892898904910916924930936942948954961967973979
98599199710021008101410211026103210381044105010561062106810941109
    This model is taken from Ajay SM, Bhalla US. Eur J Neurosci. 2004 Nov;20(10):2671-80. This is the feedback model from Figure 8a.
   
This pathway is part of accession 78 and is completely specified in the file acc78.g.
There is no separate files for just this pathway.
FormatFile
Native Format (GENESIS format)    acc78.g   
MATLAB format    acc78.m   
SBML format    acc78.xml   
20 CaM
Pathway No. 368
 Ajay_Bhalla_
2007_Bistable

Accession No. 79
NetworkMolecule = 4
Enzyme   = 0
Reaction  = 3
Molecule = 1
Enzyme   = 0
Reaction  = 0
Ajay_Bhalla_bistable_model. HFSP Journal. 2007 May;1(1):1-87/
2006-12-08
   Related Pathway: 
142781107122146160173203217236246259265273283323340358373379386392398
405411418423428434440446452458464470476482488494500506512518524530537543
549555561568573579585591597603609615621627633639645651657663669675681688
695701706712718724730736742748754760766772778784790796802808814820826832
838844850856862868874880886892898904910916924930936942948954961967973979
98599199710021008101410211026103210381044105010561062106810941109
    This is a model of ERKII signaling which is bistable due to feedback. The feedback occurs through ERKII phosphorylation of phospholipase A2 (PLA2), leading to increased production of arachidonic acid (AA), which activates protein kinase C (PKC) which activates c-Raf which is upstream of ERKII.
The model is a highly simplified variant of more detailed bistable models of MAPK signaling (Bhalla US, Iyengar R. Science. 1999 Jan 15;283(5400):381-7, Ajay SM, Bhalla US. Eur J Neurosci. 2004 Nov;20(10):2671-80)
   
This pathway is part of accession 79 and is completely specified in the file acc79.g.
There is no separate files for just this pathway.
FormatFile
Native Format (GENESIS format)    acc79.g   
MATLAB format    acc79.m   
SBML format    acc79.xml   

 
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Database compilation and code copyright (C) 2005, Upinder S. Bhalla and NCBS/TIFR
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