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Default ordering is done according to Pathway Name.Table header can be used for changing the default ordering. indicates that ordering is done according to ascending or descending order.Entries are color tagged depending on Network or Pathway ![]() |
| Pathway Name Pathway No. ![]() | Accession Name Accession No. | Accession Type | Pathway statistics | plcbeta statistics | Source Entry Date | ||||||||||||||
| 1 | PLCbeta Pathway No. 350 | Ajay_Bhalla_ 2004_Feedback_ Tuning Accession No. 78 | Network | Molecule = 6 Enzyme = 2 Reaction = 7 | Molecule = 0 Enzyme = 0 Reaction = 0 | Ajay SM, Bhalla US. Eur J Neurosci. 2004 Nov;20(10):2671-80. ( Peer-reviewed publication )/ 2006-12-12 00:00:00 | |||||||||||||
| Related Pathway: 4, 22, 67, 73, 112, 126, 151, 164, 209, 315, 332 | |||||||||||||||||||
| Group for PLC beta | |||||||||||||||||||
| 2 | PLCbeta Pathway No. 332 | Ajay_Bhalla_ 2004_PKM_MKP3_ Tuning Accession No. 77 | Network | Molecule = 6 Enzyme = 2 Reaction = 7 | Molecule = 0 Enzyme = 0 Reaction = 0 | Ajay SM, Bhalla US. Eur J Neurosci. 2004 Nov;20(10):2671-80 ( Peer-reviewed publication )/ 2006-12-12 00:00:00 | |||||||||||||
| Related Pathway: 4, 22, 67, 73, 112, 126, 151, 164, 209, 315, 350 | |||||||||||||||||||
| Group for PLC beta | |||||||||||||||||||
| 3 | PLCbeta Pathway No. 315 | Ajay_Bhalla_ 2004_PKM_Tuning Accession No. 76 | Network | Molecule = 6 Enzyme = 2 Reaction = 7 | Molecule = 0 Enzyme = 0 Reaction = 0 | Ajay SM, Bhalla US. Eur J Neurosci. 2004 Nov;20(10):2671-80. ( Peer-reviewed publication )/ 2006-12-12 00:00:00 | |||||||||||||
| Related Pathway: 4, 22, 67, 73, 112, 126, 151, 164, 209, 332, 350 | |||||||||||||||||||
| Group for PLC beta | |||||||||||||||||||
| 4 | PLCbeta Pathway No. 209 | MAPK_network_ 2003 Accession No. 50 | Network | Molecule = 6 Enzyme = 2 Reaction = 7 | Molecule = 0 Enzyme = 0 Reaction = 0 | Bhalla US Biophys J. 2004 Aug;87(2):745-53. ( peer-reviewed publication )/ 2003-04-28 00:00:00 | |||||||||||||
| Related Pathway: 4, 22, 67, 73, 112, 126, 151, 164, 315, 332, 350 | |||||||||||||||||||
| Group for PLC beta | |||||||||||||||||||
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| 5 | PLCbeta Pathway No. 164 | Osc_Ca_ IP3metabolism Accession No. 32 | Network | Molecule = 7 Enzyme = 4 Reaction = 7 | Molecule = 0 Enzyme = 0 Reaction = 0 | Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316. ( peer-reviewed publication )/ 2002-04-03 00:00:00 | |||||||||||||
| Related Pathway: 4, 22, 67, 73, 112, 126, 151, 209, 315, 332, 350 | |||||||||||||||||||
| PhospholipaseC beta. This model incorporates Ca and Gq regulation of PLCbeta that generates four separat e active forms of the enzyme: PLC, PLC-Gq, PLC-Ca and PLC-Ca-Gq. GAP activity of PLC has been included. Primary re fs: Sternweis et al 1992 Phil Trans R Soc Lond, Smrcka et al 1991 Science 251:804-807, Biddlecome et al 1996 JBC 2 71: 7999-8007 | |||||||||||||||||||
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| 6 | PLCbeta Pathway No. 151 | NonOsc_Ca_ IP3metabolism Accession No. 31 | Network | Molecule = 7 Enzyme = 4 Reaction = 7 | Molecule = 0 Enzyme = 0 Reaction = 0 | Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316. ( peer-reviewed publication )/ 2002-04-03 00:00:00 | |||||||||||||
| Related Pathway: 4, 22, 67, 73, 112, 126, 164, 209, 315, 332, 350 | |||||||||||||||||||
| PhospholipaseC beta. This model incorporates Ca and Gq regulation of PLCbeta that generates four separate active forms of the enzyme: PLC, PLC-Gq, PLC-Ca and PLC-Ca-Gq. GAP activity of PLC has been included. Primary refs: Sternweis et al 1992 Phil Trans R Soc Lond, Smrcka et al 1991 Science 251:804-807, Biddlecome et al 1996 JBC 271: 7999-8007 | |||||||||||||||||||
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| 7 | PLCbeta Pathway No. 126 | Osc_Ca_ IP3metabolism Accession No. 24 | Network | Molecule = 7 Enzyme = 4 Reaction = 7 | Molecule = 0 Enzyme = 0 Reaction = 0 | Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316. ( peer-reviewed publication )/ 2002-01-08 00:00:00 | |||||||||||||
| Related Pathway: 4, 22, 67, 73, 112, 151, 164, 209, 315, 332, 350 | |||||||||||||||||||
| PhospholipaseC beta. This model incorporates Ca and Gq regulation of PLCbeta that generates four separate active forms of the enzyme: PLC, PLC-Gq, PLC-Ca and PLC-Ca-Gq. GAP activity of PLC has been included. Primary refs: Sternweis et al 1992 Phil Trans R Soc Lond, Smrcka et al 1991 Science 251:804-807, Biddlecome et al 1996 JBC 271: 7999-8007 | |||||||||||||||||||
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| 8 | PLCbeta Pathway No. 112 | NonOsc_Ca_ IP3metabolism Accession No. 23 | Network | Molecule = 7 Enzyme = 4 Reaction = 7 | Molecule = 0 Enzyme = 0 Reaction = 0 | Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316. ( peer-reviewed publication )/ 2002-01-07 00:00:00 | |||||||||||||
| Related Pathway: 4, 22, 67, 73, 126, 151, 164, 209, 315, 332, 350 | |||||||||||||||||||
| PhospholipaseC beta. This model incorporates Ca and Gq regulation of PLCbeta that generates four separate active forms of the enzyme: PLC, PLC-Gq, PLC-Ca and PLC-Ca-Gq. GAP activity of PLC has been included. Primary refs: Sternweis et al 1992 Phil Trans R Soc Lond, Smrcka et al 1991 Science 251:804-807, Biddlecome et al 1996 JBC 271: 7999-8007 | |||||||||||||||||||
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| 9 | PLCbeta Pathway No. 73 | Synaptic_ Network Accession No. 16 | Network | Molecule = 6 Enzyme = 2 Reaction = 7 | Molecule = 0 Enzyme = 0 Reaction = 0 | Bhalla US and Iyengar R. Science (1999) 283(5400):381-7. ( peer-reviewed publication )/ 2001-12-12 00:00:00 | |||||||||||||
| Related Pathway: 4, 22, 67, 112, 126, 151, 164, 209, 315, 332, 350 | |||||||||||||||||||
| Phospholipase C beta. This model only incorporates Ca and Gq regulation, though there is evidence to show that many things, from kinase to phosphatidic acid all regulate its activity. There are various subtypes of PLCbeta: 1, 2, 3 and probably more. This version is not specific enough to be subtyped. Primary refs: Homma et al 1988 JBC 263(14):6592 Ryu et al 1987 JBC 262(26):12511 Sternweis et al 1992 Phil Trans Roy Soc Lond and especially Smrcka et al 1991 Science 251:804-807 | |||||||||||||||||||
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| 10 | PLCbeta Pathway No. 67 | PLCbeta1 Accession No. 13 | Pathway | Molecule = 10 Enzyme = 3 Reaction = 4 | Molecule = 1 Enzyme = 0 Reaction = 0 | In-house
/ 2001-11-12 00:00:00 | |||||||||||||
| Related Pathway: 4, 22, 73, 112, 126, 151, 164, 209, 315, 332, 350 | |||||||||||||||||||
| 4 Oct 2001 ---------- Initial version incorporating inputs of Ca, Gq and PA. The PA is still problematic at very high or very low levels of Ca but works OK in the range 0.1 to 1 uM. PA data primarily from Litosch 2000 Biochemistry 39:7736-7743. Gq data primarily from Sternweis et al 1992 Phil Trans Roy Soc Lond B Biol Sci 29;336(1276): 35-41 and Smrcka et al Science 251 804-807 1991. Model parameter specification H. Sridhar 2001. | |||||||||||||||||||
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| 11 | PLCbeta Pathway No. 22 | fig4_synapse Accession No. 3 | Network | Molecule = 6 Enzyme = 2 Reaction = 7 | Molecule = 0 Enzyme = 0 Reaction = 0 | Bhalla US and Iyengar R. Science (1999) 283(5400):381-7. ( peer-reviewed publication )/ 2001-11-07 00:00:00 | |||||||||||||
| Related Pathway: 4, 67, 73, 112, 126, 151, 164, 209, 315, 332, 350 | |||||||||||||||||||
| This is the composite model of 4 kinases: PKC, MAPK, PKA and CaMKII and numerous regulatory pathways involved in synaptic signaling. From Bhalla US and Iyengar R. Science (1999) 283(5400):381-7.This model comes from figure 4 of that paper. Demonstration script files for generating the figures in the paper, including figure 4, are available here. | |||||||||||||||||||
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| 12 | PLCbeta Pathway No. 4 | fig2_egfr Accession No. 1 | Network | Molecule = 6 Enzyme = 2 Reaction = 7 | Molecule = 0 Enzyme = 0 Reaction = 0 | Bhalla US and Iyengar R. Science (1999) 283(5400):381-7. ( peer-reviewed publication )/ 2001-11-07 00:00:00 | |||||||||||||
| Related Pathway: 22, 67, 73, 112, 126, 151, 164, 209, 315, 332, 350 | |||||||||||||||||||
| This network was used to generate figure 2 in Bhalla US and Iyengar R. Science (1999) 283(5400):381-7. It consists of the MAPK cascade in a feedback loop with PKC, and receives input from the EGFR in the synapse. Demonstration script files for generating the figures in the paper, including figure 2, are available here. | |||||||||||||||||||
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indicates that ordering is done according to ascending or descending order.
or Pathway 