| |
Pathway Name
Pathway No. | Accession Name
Accession No. | Accession
Type | Pathway statistics | plcbeta statistics | Source
Entry Date |
| 1 | PLCbeta
Pathway No. 350 | Ajay_Bhalla_
2004_Feedback_
Tuning
Accession No. 78 | Network | Molecule = 6
Enzyme = 2
Reaction = 7
| Molecule = 0
Enzyme = 0
Reaction = 0
| Ajay SM, Bhalla US. Eur J Neurosci. 2004 Nov;20(10):2671-80. ( Peer-reviewed publication )/
2006-12-12 00:00:00 |
| | #12Related Pathway:
4, 22, 67, 73, 112, 126, 151, 164, 209, 315, 332 |
| | Group for PLC beta |
| | This pathway is part of accession 78 and is completely specified in the file acc78.g.
There is no separate files for just this pathway. |
|
| 2 | PLCbeta
Pathway No. 332 | Ajay_Bhalla_
2004_PKM_MKP3_
Tuning
Accession No. 77 | Network | Molecule = 6
Enzyme = 2
Reaction = 7
| Molecule = 0
Enzyme = 0
Reaction = 0
| Ajay SM, Bhalla US. Eur J Neurosci. 2004 Nov;20(10):2671-80 ( Peer-reviewed publication )/
2006-12-12 00:00:00 |
| | #12Related Pathway:
4, 22, 67, 73, 112, 126, 151, 164, 209, 315, 350 |
| | Group for PLC beta |
| | This pathway is part of accession 77 and is completely specified in the file acc77.g.
There is no separate files for just this pathway. |
|
| 3 | PLCbeta
Pathway No. 315 | Ajay_Bhalla_
2004_PKM_Tuning
Accession No. 76 | Network | Molecule = 6
Enzyme = 2
Reaction = 7
| Molecule = 0
Enzyme = 0
Reaction = 0
| Ajay SM, Bhalla US. Eur J Neurosci. 2004 Nov;20(10):2671-80. ( Peer-reviewed publication )/
2006-12-12 00:00:00 |
| | #12Related Pathway:
4, 22, 67, 73, 112, 126, 151, 164, 209, 332, 350 |
| | Group for PLC beta |
| | This pathway is part of accession 76 and is completely specified in the file acc76.g.
There is no separate files for just this pathway. |
|
| 4 | PLCbeta
Pathway No. 209 | MAPK_network_
2003
Accession No. 50 | Network | Molecule = 6
Enzyme = 2
Reaction = 7
| Molecule = 0
Enzyme = 0
Reaction = 0
| Bhalla US Biophys J. 2004 Aug;87(2):745-53. ( peer-reviewed publication )/
2003-04-28 00:00:00 |
| | #12Related Pathway:
4, 22, 67, 73, 112, 126, 151, 164, 315, 332, 350 |
| | Group for PLC beta |
| | This pathway is part of accession 50 and is completely specified in the file acc50.g.
There is no separate files for just this pathway. |
|
| 5 | PLCbeta
Pathway No. 164 | Osc_Ca_
IP3metabolism
Accession No. 32 | Network | Molecule = 7
Enzyme = 4
Reaction = 7
| Molecule = 0
Enzyme = 0
Reaction = 0
| Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316. ( peer-reviewed publication )/
2002-04-03 00:00:00 |
| | #12Related Pathway:
4, 22, 67, 73, 112, 126, 151, 209, 315, 332, 350 |
| | PhospholipaseC beta. This model incorporates Ca and Gq regulation of PLCbeta that generates four separat
e active forms of the enzyme: PLC, PLC-Gq, PLC-Ca and PLC-Ca-Gq. GAP activity of PLC has been included. Primary re
fs: Sternweis et al 1992 Phil Trans R Soc Lond, Smrcka et al 1991 Science 251:804-807, Biddlecome et al 1996 JBC 2
71: 7999-8007 |
| | This pathway is part of accession 32 and is completely specified in the file acc32.g.
There is no separate files for just this pathway. |
| Format | File | | Native Format (GENESIS format) | acc32.g | | GENESIS Format (Annotated version) | Anno_acc32.g |
|
| 6 | PLCbeta
Pathway No. 151 | NonOsc_Ca_
IP3metabolism
Accession No. 31 | Network | Molecule = 7
Enzyme = 4
Reaction = 7
| Molecule = 0
Enzyme = 0
Reaction = 0
| Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316. ( peer-reviewed publication )/
2002-04-03 00:00:00 |
| | #12Related Pathway:
4, 22, 67, 73, 112, 126, 164, 209, 315, 332, 350 |
| | PhospholipaseC beta. This model incorporates Ca and Gq regulation of PLCbeta that generates four separate active forms of the enzyme: PLC, PLC-Gq, PLC-Ca and PLC-Ca-Gq. GAP activity of PLC has been included. Primary refs: Sternweis et al 1992 Phil Trans R Soc Lond, Smrcka et al 1991 Science 251:804-807, Biddlecome et al 1996 JBC 271: 7999-8007 |
| | This pathway is part of accession 31 and is completely specified in the file acc31.g.
There is no separate files for just this pathway. |
| Format | File | | Native Format (GENESIS format) | acc31.g | | GENESIS Format (Annotated version) | Anno_acc31.g |
|
| 7 | PLCbeta
Pathway No. 126 | Osc_Ca_
IP3metabolism
Accession No. 24 | Network | Molecule = 7
Enzyme = 4
Reaction = 7
| Molecule = 0
Enzyme = 0
Reaction = 0
| Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316. ( peer-reviewed publication )/
2002-01-08 00:00:00 |
| | #12Related Pathway:
4, 22, 67, 73, 112, 151, 164, 209, 315, 332, 350 |
| | PhospholipaseC beta. This model incorporates Ca and Gq regulation of PLCbeta that generates four separate active forms of the enzyme: PLC, PLC-Gq, PLC-Ca and PLC-Ca-Gq. GAP activity of PLC has been included. Primary refs: Sternweis et al 1992 Phil Trans R Soc Lond, Smrcka et al 1991 Science 251:804-807, Biddlecome et al 1996 JBC 271: 7999-8007 |
| | This pathway is part of accession 24 and is completely specified in the file acc24.g.
There is no separate files for just this pathway. |
| Format | File | | Native Format (GENESIS format) | acc24.g | | GENESIS Format (Annotated version) | Anno_acc24.g |
|
| 8 | PLCbeta
Pathway No. 112 | NonOsc_Ca_
IP3metabolism
Accession No. 23 | Network | Molecule = 7
Enzyme = 4
Reaction = 7
| Molecule = 0
Enzyme = 0
Reaction = 0
| Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316. ( peer-reviewed publication )/
2002-01-07 00:00:00 |
| | #12Related Pathway:
4, 22, 67, 73, 126, 151, 164, 209, 315, 332, 350 |
| | PhospholipaseC beta. This model incorporates Ca and Gq regulation of PLCbeta that generates four separate active forms of the enzyme: PLC, PLC-Gq, PLC-Ca and PLC-Ca-Gq. GAP activity of PLC has been included. Primary refs: Sternweis et al 1992 Phil Trans R Soc Lond, Smrcka et al 1991 Science 251:804-807, Biddlecome et al 1996 JBC 271: 7999-8007 |
| | This pathway is part of accession 23 and is completely specified in the file acc23.g.
There is no separate files for just this pathway. |
| Format | File | | Native Format (GENESIS format) | acc23.g | | GENESIS Format (Annotated version) | Anno_acc23.g |
|
| 9 | PLCbeta
Pathway No. 73 | Synaptic_
Network
Accession No. 16 | Network | Molecule = 6
Enzyme = 2
Reaction = 7
| Molecule = 0
Enzyme = 0
Reaction = 0
| Bhalla US and Iyengar R. Science (1999) 283(5400):381-7. ( peer-reviewed publication )/
2001-12-12 00:00:00 |
| | #12Related Pathway:
4, 22, 67, 112, 126, 151, 164, 209, 315, 332, 350 |
| | Phospholipase C beta. This model only incorporates Ca and Gq regulation, though there is evidence to show that many things, from kinase to phosphatidic acid all regulate its activity. There are various subtypes of PLCbeta: 1, 2, 3 and probably more. This version is not specific enough to be subtyped. Primary refs: Homma et al 1988 JBC 263(14):6592 Ryu et al 1987 JBC 262(26):12511 Sternweis et al 1992 Phil Trans Roy Soc Lond and especially Smrcka et al 1991 Science 251:804-807 |
| | This pathway is part of accession 16 and is completely specified in the file acc16.g.
There is no separate files for just this pathway. |
| Format | File | | Native Format (GENESIS format) | acc16.g | | GENESIS Format (Annotated version) | Anno_acc16.g |
|
| 10 | PLCbeta
Pathway No. 67 | PLCbeta1
Accession No. 13 | Pathway | Molecule = 10
Enzyme = 3
Reaction = 4
| Molecule = 1
Enzyme = 0
Reaction = 0
| In-house
/
2001-11-12 00:00:00 |
| | #12Related Pathway:
4, 22, 73, 112, 126, 151, 164, 209, 315, 332, 350 |
| | 4 Oct 2001 ---------- Initial version incorporating inputs of Ca, Gq and PA. The PA is still problematic at very high or very low levels of Ca but works OK in the range 0.1 to 1 uM. PA data primarily from Litosch 2000 Biochemistry 39:7736-7743. Gq data primarily from Sternweis et al 1992 Phil Trans Roy Soc Lond B Biol Sci 29;336(1276): 35-41 and Smrcka et al Science 251 804-807 1991. Model parameter specification H. Sridhar 2001. |
| | This pathway is part of accession 13 and is completely specified in the file acc13.g.
There is no separate files for just this pathway. |
|
| 11 | PLCbeta
Pathway No. 22 | fig4_synapse
Accession No. 3 | Network | Molecule = 6
Enzyme = 2
Reaction = 7
| Molecule = 0
Enzyme = 0
Reaction = 0
| Bhalla US and Iyengar R. Science (1999) 283(5400):381-7. ( peer-reviewed publication )/
2001-11-07 00:00:00 |
| | #12Related Pathway:
4, 67, 73, 112, 126, 151, 164, 209, 315, 332, 350 |
| | This is the composite model of 4 kinases: PKC, MAPK, PKA and CaMKII and numerous regulatory pathways involved in synaptic signaling. From Bhalla US and Iyengar R. Science (1999) 283(5400):381-7.This model comes from figure 4 of that paper.
Demonstration script files for generating the figures in the paper, including figure 4, are available here. |
| | This pathway is part of accession 3 and is completely specified in the file acc3.g.
There is no separate files for just this pathway. |
| Format | File | | Native Format (GENESIS format) | acc3.g | | GENESIS Format (Annotated version) | Anno_acc3.g |
|
| 12 | PLCbeta
Pathway No. 4 | fig2_egfr
Accession No. 1 | Network | Molecule = 6
Enzyme = 2
Reaction = 7
| Molecule = 0
Enzyme = 0
Reaction = 0
| Bhalla US and Iyengar R. Science (1999) 283(5400):381-7. ( peer-reviewed publication )/
2001-11-07 00:00:00 |
| | #12Related Pathway:
22, 67, 73, 112, 126, 151, 164, 209, 315, 332, 350 |
| | This network was used to generate figure 2 in Bhalla US and Iyengar R. Science (1999) 283(5400):381-7. It consists of the MAPK cascade in a feedback loop with PKC, and receives input from the EGFR in the synapse.
Demonstration script files for generating the figures in the paper, including figure 2, are available here. |
| | This pathway is part of accession 1 and is completely specified in the file acc1.g.
There is no separate files for just this pathway. |
| Format | File | | Native Format (GENESIS format) | acc1.g | | GENESIS Format (Annotated version) | Anno_acc1.g |
|
or Pathway 