| |
Reaction
Name | Accession Name /
Accession No. | Pathway Name /
Pathway No. | Kf | Kb | Kd | tau | Reagents |
| 1 | CaMKII-thr286-bi
nd-CaM-PSD | AMPAR_traff_
model0
Accession No. 59 | CaMKII
Pathway No. 235 | 1000.02
(uM^-1 s^-1) | 0.1
(s^-1) | Kd(bf) = 0.0001(uM) | - | Substrate:
CaMKII-thr286-PS
D
CaM-Ca4-PSD
Products:
CaMKII-thr286-Ca
M-PSD
|
| Same values as for the main compartment Can the main compartment pool of Ca/CaM be used? | | 2 | CaMKII-thr286-bi
nd-CaM-PSD | AMPAR_traff_
model1
Accession No. 60 | CaMKII
Pathway No. 245 | 1000.02
(uM^-1 s^-1) | 0.1
(s^-1) | Kd(bf) = 0.0001(uM) | - | Substrate:
CaMKII-thr286-PS
D
CaM-Ca4-PSD
Products:
CaMKII-thr286-Ca
M-PSD
|
| Same values as for the main compartment Can the main compartment pool of Ca/CaM be used? | | 3 | CaMKII-thr286-bi
nd-CaM-PSD | CaMKII_noPKA_
model3
Accession No. 62 | Shared_Object_
CaMKII_noPKA_
model3
Pathway No. 257 | 1000.02
(uM^-1 s^-1) | 0.1
(s^-1) | Kd(bf) = 0.0001(uM) | - | Substrate:
CaMKII-thr286-PS
D
CaM-Ca4-PSD
Products:
CaMKII-thr286-Ca
M-PSD
|
| Same values as for the main compartment Can the main compartment pool of Ca/CaM be used? | | 4 | CaMKII-thr286-bi
nd-CaM-PSD | CaMKII_model3
Accession No. 63 | Shared_Object_
CaMKII_model3
Pathway No. 263 | 1000.02
(uM^-1 s^-1) | 0.1
(s^-1) | Kd(bf) = 0.0001(uM) | - | Substrate:
CaMKII-thr286-PS
D
CaM-Ca4-PSD
Products:
CaMKII-thr286-Ca
M-PSD
|
| Same values as for the main compartment Can the main compartment pool of Ca/CaM be used? | | 5 | CaMKII-thr286-bi
nd-CaM-PSD | AMPAR_CaMKII_
strong_coupling
Accession No. 64 | Shared_Object_
AMPAR_CaMKII_
strong_coupling
Pathway No. 271 | 1000.02
(uM^-1 s^-1) | 0.1
(s^-1) | Kd(bf) = 0.0001(uM) | - | Substrate:
CaMKII-thr286-PS
D
CaM-Ca4-PSD
Products:
CaMKII-thr286-Ca
M-PSD
|
| Same values as for the main compartment Can the main compartment pool of Ca/CaM be used? | | 6 | CaMKII-thr286-bi
nd-CaM-PSD | AMPAR_CaMKII_
weak_coupling
Accession No. 65 | CaMKII_PSD
Pathway No. 292 | 1000.02
(uM^-1 s^-1) | 0.1
(s^-1) | Kd(bf) = 0.0001(uM) | - | Substrate:
CaMKII-thr286-PS
D
CaM-Ca4-PSD
Products:
CaMKII-thr286-Ca
M-PSD
|
| Same values as for the main compartment Can the main compartment pool of Ca/CaM be used? | | 7 | CaMKII-CaMCa-bin
d-Ca | CaMKII
Accession No. 33 | CaMKII
Pathway No. 174 | 100.004
(uM^-1 s^-1) | 20
(s^-1) | Kd(bf) = 0.2(uM) | - | Substrate:
CAMKII-CaMCa
Ca
Products:
CaMKII-CaMCa2
|
| 8 | CaMKII-bind-CaMC
a3 | CaMKII
Accession No. 33 | CaMKII
Pathway No. 174 | 100.004
(uM^-1 s^-1) | 22.5
(s^-1) | Kd(bf) = 0.225(uM) | - | Substrate:
CaMCa3
CaMKII
Products:
CaMKII-CaMCa3
|
| 9 | CaMKII-CaMCa2-bi
nd-Ca | CaMKII
Accession No. 33 | CaMKII
Pathway No. 174 | 100.004
(uM^-1 s^-1) | 2
(s^-1) | Kd(bf) = 0.02(uM) | - | Substrate:
CaMKII-CaMCa2
Ca
Products:
CaMKII-CaMCa3
|
| 10 | CaMKII-CaMCa3-bi
nd-Ca | CaMKII
Accession No. 33 | CaMKII
Pathway No. 174 | 100.004
(uM^-1 s^-1) | 100
(s^-1) | Kd(bf) = 1(uM) | - | Substrate:
CaMKII-CaMCa3
Ca
Products:
CaMKII-CaMCa4
|
| 11 | CaMKII-bind-CaMC
a4 | CaMKII
Accession No. 33 | CaMKII
Pathway No. 174 | 100.004
(uM^-1 s^-1) | 4.5
(s^-1) | Kd(bf) = 0.045(uM) | - | Substrate:
CaMCa4
CaMKII
Products:
CaMKII-CaMCa4
|
| 12 | CaMKIII_bind_
CaM-Ca4 | CaMKIII
Accession No. 90 | Shared_Object_
CaMKIII
Pathway No. 1093 | 99
(uM^-1 s^-1) | 0.09
(s^-1) | Kd(bf) = 0.0009(uM) | - | Substrate:
CaM-Ca4
CaMKIII
Products:
CaMKIII_CaM-Ca4
|
| 13 | CaMKII-bind-CaM | fig3_CaMKII
Accession No. 2 | CaMKII
Pathway No. 13 | 49.9998
(uM^-1 s^-1) | 5
(s^-1) | Kd(bf) = 0.1(uM) | - | Substrate:
CaM-Ca4
CaMKII
Products:
CaMKII-CaM
|
| 14 | CaMKII-bind-CaM | fig4_synapse
Accession No. 3 | CaMKII
Pathway No. 26 | 49.9998
(uM^-1 s^-1) | 5
(s^-1) | Kd(bf) = 0.1(uM) | - | Substrate:
CaM-Ca4
CaMKII
Products:
CaMKII-CaM
|
| 15 | CaMKII-bind-CaM | Synaptic_
Network
Accession No. 16 | CaMKII
Pathway No. 80 | 49.9998
(uM^-1 s^-1) | 5
(s^-1) | Kd(bf) = 0.1(uM) | - | Substrate:
CaM-Ca4
CaMKII
Products:
CaMKII-CaM
|
| This is tricky. There is some cooperativity here arising from interactions between the subunits of the CAMKII holoenzyme. However, the stoichiometry is 1. Kd = 0.1 uM. Rate is fast (see Hanson et al Neuron 12 943-956 1994) Hanson and Schulman 1992 AnnRev Biochem 61:559-601 give tau for dissoc as 0.2 sec at low Ca, 0.4 at high. Low Ca = 100 nM = physiol. | | 16 | CaMKII-bind-CaM | NonOsc_Ca_
IP3metabolism
Accession No. 23 | CaMKII
Pathway No. 106 | 49.9998
(uM^-1 s^-1) | 5
(s^-1) | Kd(bf) = 0.1(uM) | - | Substrate:
CaM-Ca4
CaMKII
Products:
CaMKII-CaM
|
| This is tricky. There is some cooperativity here arising from interactions between the subunits of the CAMKII holoenzyme. However, the stoichiometry is 1. Kd = 0.1 uM. Rate is fast (see Hanson et al Neuron 12 943-956 1994) Hanson and Schulman 1992 AnnRev Biochem 61:559-601 give tau for dissoc as 0.2 sec at low Ca, 0.4 at high. Low Ca = 100 nM = physiol. | | 17 | CaMKII-bind-CaM | Osc_Ca_
IP3metabolism
Accession No. 24 | CaMKII
Pathway No. 121 | 49.9998
(uM^-1 s^-1) | 5
(s^-1) | Kd(bf) = 0.1(uM) | - | Substrate:
CaM-Ca4
CaMKII
Products:
CaMKII-CaM
|
| This is tricky. There is some cooperativity here arising from interactions between the subunits of the CAMKII holoenzyme. However, the stoichiometry is 1. Kd = 0.1 uM. Rate is fast (see Hanson et al Neuron 12 943-956 1994) Hanson and Schulman 1992 AnnRev Biochem 61:559-601 give tau for dissoc as 0.2 sec at low Ca, 0.4 at high. Low Ca = 100 nM = physiol. | | 18 | CaMKII-bind-CaM | NonOsc_Ca_
IP3metabolism
Accession No. 31 | CaMKII
Pathway No. 145 | 49.9998
(uM^-1 s^-1) | 5
(s^-1) | Kd(bf) = 0.1(uM) | - | Substrate:
CaM-Ca4
CaMKII
Products:
CaMKII-CaM
|
| This is tricky. There is some cooperativity here arising from interactions between the subunits of the CAMKII holoenzyme. However, the stoichiometry is 1. Kd = 0.1 uM. Rate is fast (see Hanson et al Neuron 12 943-956 1994) Hanson and Schulman 1992 AnnRev Biochem 61:559-601 give tau for dissoc as 0.2 sec at low Ca, 0.4 at high. Low Ca = 100 nM = physiol. | | 19 | CaMKII-bind-CaM | Osc_Ca_
IP3metabolism
Accession No. 32 | CaMKII
Pathway No. 159 | 49.9998
(uM^-1 s^-1) | 5
(s^-1) | Kd(bf) = 0.1(uM) | - | Substrate:
CaM-Ca4
CaMKII
Products:
CaMKII-CaM
|
| This is tricky. There is some cooperativity here arising from interactions between the subunits of the CAMKII holoenzyme. However, the stoichiometry is 1. Kd = 0.1 uM. Rate is fast (see Hanson et al Neuron 12 943-956 1994) Hanson and Schulman 1992 AnnRev Biochem 61:559-601 give tau for dissoc as 0.2 sec at low Ca, 0.4 at high. Low Ca = 100 nM = physiol. | | 20 | CaMKII-bind-CaM | CaMKII_2003
Accession No. 49 | CaMKII
Pathway No. 202 | 49.9998
(uM^-1 s^-1) | 5
(s^-1) | Kd(bf) = 0.1(uM) | - | Substrate:
CaM-Ca4
CaMKII
Products:
CaMKII-CaM
|
| This is tricky. There is some cooperativity here arising from interactions between the subunits of the CAMKII holoenzyme. However, the stoichiometry is 1. Kb/Kf = 6e4 #/cell. Rate is fast (see Hanson et al Neuron 12 943-956 1994) so lets say kb = 10. This gives kf = 1.6667e-4 H&S AnnRev Biochem 92 give tau for dissoc as 0.2 sec at low Ca, 0.4 at high. Low Ca = 100 nM = physiol. |
and 
color.
