NCBS Home page
Accession List
Pathway List
Search
Authorized Users
Help
News archives

Enter a Search String

Special character and space not allowed in the query term. Search string should be at least 2 characters long.
Search in: Search for Match By

Result: 21 - 40 of 108 rows are displayed Previous of 6  Next

Reaction List for CamKII acting as a substrate

Entries are grouped according to Reaction Name and they are alternately color coded using  and  color.
Further ordering can be done to the table header.  indicates that ordering is done according to ascending or descending order.
Keq is calculated only for first order reactions.
Kd is calculated only for second order reactions. [nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules]
  Reaction
Name		Accession Name / 
Accession No.		Pathway Name / 
Pathway No.		KfKbKdtauReagents
21 basal-activity
  • MAPK_network_
    2003
    Accession No. 50
    		• CaMKII

    Pathway No. 216    		0.003
    (s^-1)    		0
    (s^-1)    		--  Substrate:
    CaMKII

     Products:
     CaMKII-thr286
      This reaction represents one of the big unknowns in CaMK-II biochemistry: what maintains the basal level of phosphorylation on thr 286 ? See Hanson and Schulman Ann Rev Biochem 1992 61:559-601, specially pg 580, for review. I have not been able to find any compelling mechanism in the literature, but fortunately the level of basal activity is well documented.
    22 basal-activity
  • Ajay_Bhalla_
    2004_PKM_Tuning
    Accession No. 76
    		• CaMKII

    Pathway No. 322    		0.003
    (s^-1)    		0
    (s^-1)    		--  Substrate:
    CaMKII

     Products:
     CaMKII-thr286
      This reaction represents one of the big unknowns in CaMK-II biochemistry: what maintains the basal level of phosphorylation on thr 286 ? See Hanson and Schulman Ann Rev Biochem 1992 61:559-601, specially pg 580, for review. I have not been able to find any compelling mechanism in the literature, but fortunately the level of basal activity is well documented.
    23 basal-activity
  • Ajay_Bhalla_
    2004_PKM_MKP3_
    Tuning
    Accession No. 77
    		• CaMKII

    Pathway No. 339    		0.003
    (s^-1)    		0
    (s^-1)    		--  Substrate:
    CaMKII

     Products:
     CaMKII-thr286
      This reaction represents one of the big unknowns in CaMK-II biochemistry: what maintains the basal level of phosphorylation on thr 286 ? See Hanson and Schulman Ann Rev Biochem 1992 61:559-601, specially pg 580, for review. I have not been able to find any compelling mechanism in the literature, but fortunately the level of basal activity is well documented.
    24 basal-activity
  • Ajay_Bhalla_
    2004_Feedback_
    Tuning
    Accession No. 78
    		• CaMKII

    Pathway No. 357    		0.003
    (s^-1)    		0
    (s^-1)    		--  Substrate:
    CaMKII

     Products:
     CaMKII-thr286
      This reaction represents one of the big unknowns in CaMK-II biochemistry: what maintains the basal level of phosphorylation on thr 286 ? See Hanson and Schulman Ann Rev Biochem 1992 61:559-601, specially pg 580, for review. I have not been able to find any compelling mechanism in the literature, but fortunately the level of basal activity is well documented.
    25 
  • CaMK-thr286-bind
    -CaM
    		• fig3_CaMKII

    Accession No. 2    		CaMKII

    Pathway No. 13    		1000.2
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 0.0001(uM)-  Substrate:
    CaMKII-thr286
    CaM-Ca4

     Products:
  •  CaMKII-thr286*-C
    aM
    • 26 
  • CaMK-thr286-bind
    -CaM
    		• fig4_synapse

    Accession No. 3    		CaMKII

    Pathway No. 26    		1000.2
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 0.0001(uM)-  Substrate:
    CaMKII-thr286
    CaM-Ca4

     Products:
  •  CaMKII-thr286*-C
    aM
    • 27 
  • CaMK-thr286-bind
    -CaM
  • Synaptic_
    Network
    Accession No. 16
    		• CaMKII

    Pathway No. 80    		1000.2
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 0.0001(uM)-  Substrate:
    CaMKII-thr286
    CaM-Ca4

     Products:
  •  CaMKII-thr286*-C
    aM
    •   Affinity is up 1000X over the unphosphorylated CaMKII, which makes the Kd of 0.1 nM. See Hanson et al 1994 Neuron 12:943-956. Time to release is about 20 sec, so the kb is OK at 0.1/sec. as tested by a few runs.
    28 
  • CaMK-thr286-bind
    -CaM
  • NonOsc_Ca_
    IP3metabolism
    Accession No. 23
    		• CaMKII

    Pathway No. 106    		1000.2
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 0.0001(uM)-  Substrate:
    CaMKII-thr286
    CaM-Ca4

     Products:
  •  CaMKII-thr286*-C
    aM
    •   Affinity is up 1000X over the unphosphorylated CaMKII, which makes the Kd of 0.1 nM. See Hanson et al 1994 Neuron 12:943-956. Time to release is about 20 sec, so the kb is OK at 0.1/sec. as tested by a few runs.
    29 
  • CaMK-thr286-bind
    -CaM
  • Osc_Ca_
    IP3metabolism
    Accession No. 24
    		• CaMKII

    Pathway No. 121    		1000.2
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 0.0001(uM)-  Substrate:
    CaMKII-thr286
    CaM-Ca4

     Products:
  •  CaMKII-thr286*-C
    aM
    •   Affinity is up 1000X over the unphosphorylated CaMKII, which makes the Kd of 0.1 nM. See Hanson et al 1994 Neuron 12:943-956. Time to release is about 20 sec, so the kb is OK at 0.1/sec. as tested by a few runs.
    30 
  • CaMK-thr286-bind
    -CaM
  • NonOsc_Ca_
    IP3metabolism
    Accession No. 31
    		• CaMKII

    Pathway No. 145    		1000.2
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 0.0001(uM)-  Substrate:
    CaMKII-thr286
    CaM-Ca4

     Products:
  •  CaMKII-thr286*-C
    aM
    •   Affinity is up 1000X over the unphosphorylated CaMKII, which makes the Kd of 0.1 nM. See Hanson et al 1994 Neuron 12:943-956. Time to release is about 20 sec, so the kb is OK at 0.1/sec. as tested by a few runs.
    31 
  • CaMK-thr286-bind
    -CaM
  • Osc_Ca_
    IP3metabolism
    Accession No. 32
    		• CaMKII

    Pathway No. 159    		1000.2
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 0.0001(uM)-  Substrate:
    CaMKII-thr286
    CaM-Ca4

     Products:
  •  CaMKII-thr286*-C
    aM
    •   Affinity is up 1000X over the unphosphorylated CaMKII, which makes the Kd of 0.1 nM. See Hanson et al 1994 Neuron 12:943-956. Time to release is about 20 sec, so the kb is OK at 0.1/sec. as tested by a few runs.
    32 
  • CaMK-thr286-bind
    -CaM
    		• CaMKII_2003

    Accession No. 49    		CaMKII

    Pathway No. 202    		1000.2
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 0.0001(uM)-  Substrate:
    CaMKII-thr286
    CaM-Ca4

     Products:
  •  CaMKII-thr286*-C
    aM
    •   Affinity is up 1000X. Time to release is about 20 sec, so the kb is OK at 0.1 This makes Kf around 1.6666e-3
    33 
  • CaMK-thr286-bind
    -CaM
  • MAPK_network_
    2003
    Accession No. 50
    		• CaMKII

    Pathway No. 216    		1000.2
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 0.0001(uM)-  Substrate:
    CaMKII-thr286
    CaM-Ca4

     Products:
  •  CaMKII-thr286*-C
    aM
    •   Affinity is up 1000X. Time to release is about 20 sec, so the kb is OK at 0.1 This makes Kf around 1.6666e-3
    34 
  • CaMK-thr286-bind
    -CaM
  • AMPAR_traff_
    model0
    Accession No. 59
    		• CaMKII

    Pathway No. 235    		1000.19
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 0.0001(uM)-  Substrate:
    CaMKII-thr286
    CaM-Ca4

     Products:
  •  CaMKII-thr286*-C
    aM
    •   Affinity is up 1000X. Time to release is about 20 sec, so the kb is OK at 0.1 This makes Kf around 1.6666e-3
    35 
  • CaMK-thr286-bind
    -CaM
  • AMPAR_traff_
    model1
    Accession No. 60
    		• CaMKII

    Pathway No. 245    		1000.19
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 0.0001(uM)-  Substrate:
    CaMKII-thr286
    CaM-Ca4

     Products:
  •  CaMKII-thr286*-C
    aM
    •   Affinity is up 1000X. Time to release is about 20 sec, so the kb is OK at 0.1 This makes Kf around 1.6666e-3
    36 
  • CaMK-thr286-bind
    -CaM
  • CaMKII_noPKA_
    model3
    Accession No. 62
    		• CaMKII

    Pathway No. 258    		1000.19
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 0.0001(uM)-  Substrate:
    CaMKII-thr286
    CaM-Ca4

     Products:
  •  CaMKII-thr286*-C
    aM
    •   Affinity is up 1000X. Time to release is about 20 sec, so the kb is OK at 0.1 This makes Kf around 1.6666e-3
    37 
  • CaMK-thr286-bind
    -CaM
    		• CaMKII_model3

    Accession No. 63    		CaMKII

    Pathway No. 264    		1000.19
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 0.0001(uM)-  Substrate:
    CaMKII-thr286
    CaM-Ca4

     Products:
  •  CaMKII-thr286*-C
    aM
    •   Affinity is up 1000X. Time to release is about 20 sec, so the kb is OK at 0.1 This makes Kf around 1.6666e-3
    38 
  • CaMK-thr286-bind
    -CaM
  • AMPAR_CaMKII_
    strong_coupling
    Accession No. 64
    		• CaMKII

    Pathway No. 272    		1000.19
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 0.0001(uM)-  Substrate:
    CaMKII-thr286
    CaM-Ca4

     Products:
  •  CaMKII-thr286*-C
    aM
    •   Affinity is up 1000X. Time to release is about 20 sec, so the kb is OK at 0.1 This makes Kf around 1.6666e-3
    39 
  • CaMK-thr286-bind
    -CaM
  • AMPAR_CaMKII_
    weak_coupling
    Accession No. 65
    		• CaMKII

    Pathway No. 282    		1000.19
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 0.0001(uM)-  Substrate:
    CaMKII-thr286
    CaM-Ca4

     Products:
  •  CaMKII-thr286*-C
    aM
    •   Affinity is up 1000X. Time to release is about 20 sec, so the kb is OK at 0.1 This makes Kf around 1.6666e-3
    40 
  • CaMK-thr286-bind
    -CaM
  • Ajay_Bhalla_
    2004_PKM_Tuning
    Accession No. 76
    		• CaMKII

    Pathway No. 322    		1000.17
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 0.0001(uM)-  Substrate:
    CaMKII-thr286
    CaM-Ca4

     Products:
  •  CaMKII-thr286*-C
    aM
    •   Affinity is up 1000X. Time to release is about 20 sec, so the kb is OK at 0.1 This makes Kf around 1.6666e-3
    Result: 21 - 40 of 108 rows are displayed Previous of 6  Next


    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
    This Copyright is applied to ensure that the contents of this database remain freely available. Please see FAQ for details.