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Pathway List for mapk | Default ordering is done according to Pathway Name.Table header can be used for changing the default ordering.
  indicates that ordering is done according to ascending or descending order.
Entries are color tagged depending on Network  or Pathway  |
| |
Pathway Name
Pathway No. | Accession Name
Accession No. | Accession
Type | Pathway statistics | mapk statistics | Source
Entry Date | | 1 | MAPK
Pathway No. 75 | Synaptic_
Network
Accession No. 16 | Network | Molecule = 9
Enzyme = 4
Reaction = 0
| Molecule = 1
Enzyme = 0
Reaction = 0
| Bhalla US and Iyengar R. Science (1999) 283(5400):381-7. ( peer-reviewed publication )/
2001-12-12 00:00:00 | | | #132Related Pathway:
6, 24, 35, 56, 61, 139, 142, 182, 193, 211, 230, 317, 335, 352, 366, 371, 377, 384, 390, 396, 402, 403, 409, 415, 421
432, 438, 444, 450, 456, 462, 468, 474, 480, 486, 492, 498, 504, 510, 516, 522, 528, 535, 541, 547, 553, 559, 565, 571
577, 583, 589, 595, 601, 607, 613, 619, 625, 631, 637, 643, 649, 655, 661, 667, 673, 679, 686, 692, 699, 704, 710, 716
722, 728, 734, 740, 746, 752, 758, 764, 770, 776, 782, 788, 794, 800, 806, 812, 818, 824, 830, 836, 842, 848, 854, 860
866, 872, 878, 884, 890, 896, 902, 908, 914, 921, 928, 934, 940, 946, 952, 958, 960, 965, 971, 977, 983, 989, 995
1006, 1012, 1018, 1024, 1030, 1036, 1042, 1048, 1054, 1060, 1066 | | | The Mitogen Activated Protein Kinase (MAPK) cascade model here includes both the MAPK cascade and its regulation by MKP-1. MKP-1 is induced upon MAPK activation, whereas MKP-2 is treated as a steady level of protein. For the purposes of this version of the model, MKP-1 is kept at a fixed starting value. The phosphatase Protein phosphatase 2 A (PP2A) is also included in this model to balance the activity of the kinases. | | | This pathway is part of accession 16 and is completely specified in the file acc16.g.
There is no separate files for just this pathway. |
| Format | File | | Native Format (GENESIS format) | acc16.g | | GENESIS Format (Annotated version) | Anno_acc16.g |
| | 2 | MAPK
Pathway No. 35 | mkp1_feedback_
effects
Accession No. 4 | Network | Molecule = 16
Enzyme = 9
Reaction = 8
| Molecule = 1
Enzyme = 0
Reaction = 0
| Bhalla US et al. Science (2002) 297(5583):1018-23. ( peer-reviewed publication )/
2001-11-07 00:00:00 | | | #132Related Pathway:
6, 24, 56, 61, 75, 139, 142, 182, 193, 211, 230, 317, 335, 352, 366, 371, 377, 384, 390, 396, 402, 403, 409, 415, 421
432, 438, 444, 450, 456, 462, 468, 474, 480, 486, 492, 498, 504, 510, 516, 522, 528, 535, 541, 547, 553, 559, 565, 571
577, 583, 589, 595, 601, 607, 613, 619, 625, 631, 637, 643, 649, 655, 661, 667, 673, 679, 686, 692, 699, 704, 710, 716
722, 728, 734, 740, 746, 752, 758, 764, 770, 776, 782, 788, 794, 800, 806, 812, 818, 824, 830, 836, 842, 848, 854, 860
866, 872, 878, 884, 890, 896, 902, 908, 914, 921, 928, 934, 940, 946, 952, 958, 960, 965, 971, 977, 983, 989, 995
1006, 1012, 1018, 1024, 1030, 1036, 1042, 1048, 1054, 1060, 1066 | | | The Mitogen Activated Protein Kinase (MAPK) cascade model here includes both the MAPK cascade and its regulation by two forms of MKP. MKP-1 is induced upon MAPK activation, whereas MKP-2 is treated as a steady level of protein. The phosphatase Protein phosphatase 2 A (PP2A) is also included in this model to balance the activity of the kinases. | | | This pathway is part of accession 4 and is completely specified in the file acc4.g.
There is no separate files for just this pathway. |
| | 3 | MAPK
Pathway No. 139 | MAPK_osc
Accession No. 27 | Pathway | Molecule = 15
Enzyme = 10
Reaction = 1
| Molecule = 1
Enzyme = 0
Reaction = 0
| Boris N. Kholodenko Eur J Biochem. (2000) 267(6):1583-8). ( peer-reviewed publication )/
2002-01-22 00:00:00 | | | #132Related Pathway:
6, 24, 35, 56, 61, 75, 142, 182, 193, 211, 230, 317, 335, 352, 366, 371, 377, 384, 390, 396, 402, 403, 409, 415, 421
432, 438, 444, 450, 456, 462, 468, 474, 480, 486, 492, 498, 504, 510, 516, 522, 528, 535, 541, 547, 553, 559, 565, 571
577, 583, 589, 595, 601, 607, 613, 619, 625, 631, 637, 643, 649, 655, 661, 667, 673, 679, 686, 692, 699, 704, 710, 716
722, 728, 734, 740, 746, 752, 758, 764, 770, 776, 782, 788, 794, 800, 806, 812, 818, 824, 830, 836, 842, 848, 854, 860
866, 872, 878, 884, 890, 896, 902, 908, 914, 921, 928, 934, 940, 946, 952, 958, 960, 965, 971, 977, 983, 989, 995
1006, 1012, 1018, 1024, 1030, 1036, 1042, 1048, 1054, 1060, 1066 | | | This is the oscillatory MAPK model from Kholodenko 2000 Eur J. Biochem 267:1583-1588 The original model is formulated in terms of idealized Michaelis-Menten enzymes and the enzyme-substrate complex concentrations are therefore assumed negligible. The current implementation of the model uses explicit enzyme reactions involving substrates and is therefore an approximation to the Kholodenko model. The approximation is greatly improved if the enzyme is flagged as Available which is an option in Kinetikit. This flag means that the enzyme protein concentration is not reduced even when it is involved in a complex. However, the substrate protein continues to participate in enzyme-substrate complexes and its concentration is therefore affected. Overall, this model works almost the same as the Kholodenko model but the peak MAPK-PP amplitudes are a little reduced and the period of oscillations is about 10% longer. If the enzymes are not flagged as Available then the oscillations commence only when the Km for enzyme 1 is set to 0.1 uM. | | | This pathway is part of accession 27 and is completely specified in the file acc27.g.
There is no separate files for just this pathway. |
| | 4 | MAPK
Pathway No. 211 | MAPK_network_
2003
Accession No. 50 | Network | Molecule = 9
Enzyme = 4
Reaction = 0
| Molecule = 1
Enzyme = 0
Reaction = 0
| Bhalla US Biophys J. 2004 Aug;87(2):745-53. ( peer-reviewed publication )/
2003-04-28 00:00:00 | | | #132Related Pathway:
6, 24, 35, 56, 61, 75, 139, 142, 182, 193, 230, 317, 335, 352, 366, 371, 377, 384, 390, 396, 402, 403, 409, 415, 421
432, 438, 444, 450, 456, 462, 468, 474, 480, 486, 492, 498, 504, 510, 516, 522, 528, 535, 541, 547, 553, 559, 565, 571
577, 583, 589, 595, 601, 607, 613, 619, 625, 631, 637, 643, 649, 655, 661, 667, 673, 679, 686, 692, 699, 704, 710, 716
722, 728, 734, 740, 746, 752, 758, 764, 770, 776, 782, 788, 794, 800, 806, 812, 818, 824, 830, 836, 842, 848, 854, 860
866, 872, 878, 884, 890, 896, 902, 908, 914, 921, 928, 934, 940, 946, 952, 958, 960, 965, 971, 977, 983, 989, 995
1006, 1012, 1018, 1024, 1030, 1036, 1042, 1048, 1054, 1060, 1066 | | | This is a network model of many pathways present at the neuronal synapse. The network has properties of temporal tuning as well as steady-state computational properties. In its default form the network is bistable.Bhalla US Biophys J. 2004 Aug;87(2):745-53 | | | This pathway is part of accession 50 and is completely specified in the file acc50.g.
There is no separate files for just this pathway. |
| | 5 | MAPK
Pathway No. 61 | MAPK_MKP1_
oscillation
Accession No. 9 | Network | Molecule = 15
Enzyme = 9
Reaction = 7
| Molecule = 1
Enzyme = 0
Reaction = 0
| Bhalla US, Iyengar R. Chaos (2001) 11(1):221-226. ( peer-reviewed publication )/
2001-11-08 00:00:00 | | | #132Related Pathway:
6, 24, 35, 56, 75, 139, 142, 182, 193, 211, 230, 317, 335, 352, 366, 371, 377, 384, 390, 396, 402, 403, 409, 415, 421
432, 438, 444, 450, 456, 462, 468, 474, 480, 486, 492, 498, 504, 510, 516, 522, 528, 535, 541, 547, 553, 559, 565, 571
577, 583, 589, 595, 601, 607, 613, 619, 625, 631, 637, 643, 649, 655, 661, 667, 673, 679, 686, 692, 699, 704, 710, 716
722, 728, 734, 740, 746, 752, 758, 764, 770, 776, 782, 788, 794, 800, 806, 812, 818, 824, 830, 836, 842, 848, 854, 860
866, 872, 878, 884, 890, 896, 902, 908, 914, 921, 928, 934, 940, 946, 952, 958, 960, 965, 971, 977, 983, 989, 995
1006, 1012, 1018, 1024, 1030, 1036, 1042, 1048, 1054, 1060, 1066 | | | This model relates to figure 5 in Bhalla US, Iyengar R. Chaos (2001) 11(1):221-226. It includes the model used for figures 2-4 and also has MKP-1 induction by MAPK activity in the synapse. PP2A is set to 0.16 uM and MKP synthesis is varied from 5x to 40 x basal to get a range of interesting behaviours. | | | This pathway is part of accession 9 and is completely specified in the file acc9.g.
There is no separate files for just this pathway. |
| | 6 | MAPK
Pathway No. 193 | MAPK_Asthagiri_
adapt_fb
Accession No. 45 | Pathway | Molecule = 26
Enzyme = 11
Reaction = 7
| Molecule = 0
Enzyme = 0
Reaction = 0
| Asthagiri AR and Lauffenburger DA. Biotechnol Prog. (2001) 17(2):227-39. ( peer-reviewed publication )./
2003-02-22 00:00:00 | | | #132Related Pathway:
6, 24, 35, 56, 61, 75, 139, 142, 182, 211, 230, 317, 335, 352, 366, 371, 377, 384, 390, 396, 402, 403, 409, 415, 421
432, 438, 444, 450, 456, 462, 468, 474, 480, 486, 492, 498, 504, 510, 516, 522, 528, 535, 541, 547, 553, 559, 565, 571
577, 583, 589, 595, 601, 607, 613, 619, 625, 631, 637, 643, 649, 655, 661, 667, 673, 679, 686, 692, 699, 704, 710, 716
722, 728, 734, 740, 746, 752, 758, 764, 770, 776, 782, 788, 794, 800, 806, 812, 818, 824, 830, 836, 842, 848, 854, 860
866, 872, 878, 884, 890, 896, 902, 908, 914, 921, 928, 934, 940, 946, 952, 958, 960, 965, 971, 977, 983, 989, 995
1006, 1012, 1018, 1024, 1030, 1036, 1042, 1048, 1054, 1060, 1066 | | | This is a complex model to examine mechanisms that govern MAPK pathway dynamics in Chinese hamster ovary (CHO) cell lines, particularly the role of adapter targeted negative feedback mechanism in generating complete signal adaptation. This model simulates the results as per the figure 7A of the paper by Asthagiri AR and Lauffenburger DA. Biotechnol Prog. (2001) 17(2):227-39. | | | This pathway is part of accession 45 and is completely specified in the file acc45.g.
There is no separate files for just this pathway. |
| | 7 | MAPK
Pathway No. 182 | MAPK-bistability
-fig1c
Accession No. 35 | Network | Molecule = 10
Enzyme = 6
Reaction = 0
| Molecule = 1
Enzyme = 0
Reaction = 0
| Bhalla US et al. Science (2002) 297(5583):1018-23 ( peer-reviewed publication )./
2002-11-07 00:00:00 | | | #132Related Pathway:
6, 24, 35, 56, 61, 75, 139, 142, 193, 211, 230, 317, 335, 352, 366, 371, 377, 384, 390, 396, 402, 403, 409, 415, 421
432, 438, 444, 450, 456, 462, 468, 474, 480, 486, 492, 498, 504, 510, 516, 522, 528, 535, 541, 547, 553, 559, 565, 571
577, 583, 589, 595, 601, 607, 613, 619, 625, 631, 637, 643, 649, 655, 661, 667, 673, 679, 686, 692, 699, 704, 710, 716
722, 728, 734, 740, 746, 752, 758, 764, 770, 776, 782, 788, 794, 800, 806, 812, 818, 824, 830, 836, 842, 848, 854, 860
866, 872, 878, 884, 890, 896, 902, 908, 914, 921, 928, 934, 940, 946, 952, 958, 960, 965, 971, 977, 983, 989, 995
1006, 1012, 1018, 1024, 1030, 1036, 1042, 1048, 1054, 1060, 1066 | | | The Mitogen Activated Protein Kinase (MAPK) cascade model here includes both the MAPK cascade and its regulation by two forms of MKP. MKP-1 is induced upon MAPK activation, whereas MKP-2 is treated as a steady level of protein. The phosphatase Protein phosphatase 2 A (PP2A) is also included in this model to balance the activity of the kinases. | | | This pathway is part of accession 35 and is completely specified in the file acc35.g.
There is no separate files for just this pathway. |
| | 8 | MAPK
Pathway No. 142 | Huang_Ferrell_
MAPK
Accession No. 30 | Pathway | Molecule = 14
Enzyme = 10
Reaction = 0
| Molecule = 1
Enzyme = 0
Reaction = 0
| Huang CY and Ferrell JE Jr. Proc Natl Acad Sci U S A. (1996) 93(19):10078-83 ( peer-reviewed publication )/
2002-01-31 00:00:00 | | | #132Related Pathway:
6, 24, 35, 56, 61, 75, 139, 182, 193, 211, 230, 317, 335, 352, 366, 371, 377, 384, 390, 396, 402, 403, 409, 415, 421
432, 438, 444, 450, 456, 462, 468, 474, 480, 486, 492, 498, 504, 510, 516, 522, 528, 535, 541, 547, 553, 559, 565, 571
577, 583, 589, 595, 601, 607, 613, 619, 625, 631, 637, 643, 649, 655, 661, 667, 673, 679, 686, 692, 699, 704, 710, 716
722, 728, 734, 740, 746, 752, 758, 764, 770, 776, 782, 788, 794, 800, 806, 812, 818, 824, 830, 836, 842, 848, 854, 860
866, 872, 878, 884, 890, 896, 902, 908, 914, 921, 928, 934, 940, 946, 952, 958, 960, 965, 971, 977, 983, 989, 995
1006, 1012, 1018, 1024, 1030, 1036, 1042, 1048, 1054, 1060, 1066 | | | MAPK model by Huang, C.-Y.F. and Ferrell Jr., J.E. 1996 PNAS USA 93:10078-10083 The parameters are based on the Mathematica code for the model which was kindly supplied by Prof. Ferrell. This simulation very closely replicates figure 2 from the paper. | | | This pathway is part of accession 30 and is completely specified in the file acc30.g.
There is no separate files for just this pathway. |
| | 9 | MAPK
Pathway No. 24 | fig4_synapse
Accession No. 3 | Network | Molecule = 9
Enzyme = 4
Reaction = 0
| Molecule = 1
Enzyme = 0
Reaction = 0
| Bhalla US and Iyengar R. Science (1999) 283(5400):381-7. ( peer-reviewed publication )/
2001-11-07 00:00:00 | | | #132Related Pathway:
6, 35, 56, 61, 75, 139, 142, 182, 193, 211, 230, 317, 335, 352, 366, 371, 377, 384, 390, 396, 402, 403, 409, 415, 421
432, 438, 444, 450, 456, 462, 468, 474, 480, 486, 492, 498, 504, 510, 516, 522, 528, 535, 541, 547, 553, 559, 565, 571
577, 583, 589, 595, 601, 607, 613, 619, 625, 631, 637, 643, 649, 655, 661, 667, 673, 679, 686, 692, 699, 704, 710, 716
722, 728, 734, 740, 746, 752, 758, 764, 770, 776, 782, 788, 794, 800, 806, 812, 818, 824, 830, 836, 842, 848, 854, 860
866, 872, 878, 884, 890, 896, 902, 908, 914, 921, 928, 934, 940, 946, 952, 958, 960, 965, 971, 977, 983, 989, 995
1006, 1012, 1018, 1024, 1030, 1036, 1042, 1048, 1054, 1060, 1066 | | | This is the composite model of 4 kinases: PKC, MAPK, PKA and CaMKII and numerous regulatory pathways involved in synaptic signaling. From Bhalla US and Iyengar R. Science (1999) 283(5400):381-7.This model comes from figure 4 of that paper.
Demonstration script files for generating the figures in the paper, including figure 4, are available here. | | | This pathway is part of accession 3 and is completely specified in the file acc3.g.
There is no separate files for just this pathway. |
| Format | File | | Native Format (GENESIS format) | acc3.g | | GENESIS Format (Annotated version) | Anno_acc3.g |
| | 10 | MAPK
Pathway No. 6 | fig2_egfr
Accession No. 1 | Network | Molecule = 9
Enzyme = 4
Reaction = 0
| Molecule = 1
Enzyme = 0
Reaction = 0
| Bhalla US and Iyengar R. Science (1999) 283(5400):381-7. ( peer-reviewed publication )/
2001-11-07 00:00:00 | | | #132Related Pathway:
24, 35, 56, 61, 75, 139, 142, 182, 193, 211, 230, 317, 335, 352, 366, 371, 377, 384, 390, 396, 402, 403, 409, 415
421, 432, 438, 444, 450, 456, 462, 468, 474, 480, 486, 492, 498, 504, 510, 516, 522, 528, 535, 541, 547, 553, 559, 565
571, 577, 583, 589, 595, 601, 607, 613, 619, 625, 631, 637, 643, 649, 655, 661, 667, 673, 679, 686, 692, 699, 704, 710
716, 722, 728, 734, 740, 746, 752, 758, 764, 770, 776, 782, 788, 794, 800, 806, 812, 818, 824, 830, 836, 842, 848, 854
860, 866, 872, 878, 884, 890, 896, 902, 908, 914, 921, 928, 934, 940, 946, 952, 958, 960, 965, 971, 977, 983, 989, 995
1006, 1012, 1018, 1024, 1030, 1036, 1042, 1048, 1054, 1060, 1066 | | | This network was used to generate figure 2 in Bhalla US and Iyengar R. Science (1999) 283(5400):381-7. It consists of the MAPK cascade in a feedback loop with PKC, and receives input from the EGFR in the synapse.
Demonstration script files for generating the figures in the paper, including figure 2, are available here. | | | This pathway is part of accession 1 and is completely specified in the file acc1.g.
There is no separate files for just this pathway. |
| Format | File | | Native Format (GENESIS format) | acc1.g | | GENESIS Format (Annotated version) | Anno_acc1.g |
| | 11 | MAPK
Pathway No. 230 | EGFR_MAPK
Accession No. 58 | Network | Molecule = 9
Enzyme = 4
Reaction = 0
| Molecule = 1
Enzyme = 0
Reaction = 0
| Bhalla US. Biophys J. (2004) 87(2):745-53. ( peer-reviewed publication )/
2004-01-14 00:00:00 | | | #132Related Pathway:
6, 24, 35, 56, 61, 75, 139, 142, 182, 193, 211, 317, 335, 352, 366, 371, 377, 384, 390, 396, 402, 403, 409, 415, 421
432, 438, 444, 450, 456, 462, 468, 474, 480, 486, 492, 498, 504, 510, 516, 522, 528, 535, 541, 547, 553, 559, 565, 571
577, 583, 589, 595, 601, 607, 613, 619, 625, 631, 637, 643, 649, 655, 661, 667, 673, 679, 686, 692, 699, 704, 710, 716
722, 728, 734, 740, 746, 752, 758, 764, 770, 776, 782, 788, 794, 800, 806, 812, 818, 824, 830, 836, 842, 848, 854, 860
866, 872, 878, 884, 890, 896, 902, 908, 914, 921, 928, 934, 940, 946, 952, 958, 960, 965, 971, 977, 983, 989, 995
1006, 1012, 1018, 1024, 1030, 1036, 1042, 1048, 1054, 1060, 1066 | | | Model of MAPK activation by EGFR in the synapse. Demonstration programs using this model are available here.
Primary citation:Bhalla US. Biophys J. (2004) 87(2):745-53. | | | This pathway is part of accession 58 and is completely specified in the file acc58.g.
There is no separate files for just this pathway. |
| | 12 | MAPK
Pathway No. 921 | Ajay_Bhalla_
2007_ReacDiff3
Accession No. 84 | Network | Molecule = 10
Enzyme = 6
Reaction = 0
| Molecule = 1
Enzyme = 0
Reaction = 0
| Ajay_Bhalla_bistable_model. HFSP Journal. 2007 May;1(1):1-87/
2006-12-08 00:00:00 | | | #132Related Pathway:
6, 24, 35, 56, 61, 75, 139, 142, 182, 193, 211, 230, 317, 335, 352, 366, 371, 377, 384, 390, 396, 402, 403, 409, 415
421, 432, 438, 444, 450, 456, 462, 468, 474, 480, 486, 492, 498, 504, 510, 516, 522, 528, 535, 541, 547, 553, 559, 565
571, 577, 583, 589, 595, 601, 607, 613, 619, 625, 631, 637, 643, 649, 655, 661, 667, 673, 679, 686, 692, 699, 704, 710
716, 722, 728, 734, 740, 746, 752, 758, 764, 770, 776, 782, 788, 794, 800, 806, 812, 818, 824, 830, 836, 842, 848, 854
860, 866, 872, 878, 884, 890, 896, 902, 908, 914, 928, 934, 940, 946, 952, 958, 960, 965, 971, 977, 983, 989, 995
1006, 1012, 1018, 1024, 1030, 1036, 1042, 1048, 1054, 1060, 1066 | | | This is a 25-compartment reaction-diffusion version of the Ajay_Bhalla_2007_bistable model. The original single-compartment model is repeated 25 times.
In addition, a subset (33 out of 50) molecules can diffuse between compartments. Diffusion is implemented as a reaction between corresponding molecules in neighboring compartments. Here D = 1e-13 m^2/sec (i.e., 0.1 micron^2/sec ) so the kf and kb of this reaction for these 10 micron compartments are both 0.001/sec.
The basal calcium level in this model is held at 95 nM which is rather close to threshold for the flip to the active state. This is necessary to sustain active propagation of activation.
The stimulus file bis6-propgn_D1e-13_FigEF which was used for the model to replicate Figure 4E and 4F from the paper. | | | This pathway is part of accession 84 and is completely specified in the file acc84.g.
There is no separate for just this pathway. |
| | 13 | MAPK
Pathway No. 928 | Ajay_Bhalla_
2007_ReacDiff3
Accession No. 84 | Network | Molecule = 10
Enzyme = 6
Reaction = 0
| Molecule = 1
Enzyme = 0
Reaction = 0
| Ajay_Bhalla_bistable_model. HFSP Journal. 2007 May;1(1):1-87/
2006-12-08 00:00:00 | | | #132Related Pathway:
6, 24, 35, 56, 61, 75, 139, 142, 182, 193, 211, 230, 317, 335, 352, 366, 371, 377, 384, 390, 396, 402, 403, 409, 415
421, 432, 438, 444, 450, 456, 462, 468, 474, 480, 486, 492, 498, 504, 510, 516, 522, 528, 535, 541, 547, 553, 559, 565
571, 577, 583, 589, 595, 601, 607, 613, 619, 625, 631, 637, 643, 649, 655, 661, 667, 673, 679, 686, 692, 699, 704, 710
716, 722, 728, 734, 740, 746, 752, 758, 764, 770, 776, 782, 788, 794, 800, 806, 812, 818, 824, 830, 836, 842, 848, 854
860, 866, 872, 878, 884, 890, 896, 902, 908, 914, 921, 934, 940, 946, 952, 958, 960, 965, 971, 977, 983, 989, 995
1006, 1012, 1018, 1024, 1030, 1036, 1042, 1048, 1054, 1060, 1066 | | | This is a 25-compartment reaction-diffusion version of the Ajay_Bhalla_2007_bistable model. The original single-compartment model is repeated 25 times.
In addition, a subset (33 out of 50) molecules can diffuse between compartments. Diffusion is implemented as a reaction between corresponding molecules in neighboring compartments. Here D = 1e-13 m^2/sec (i.e., 0.1 micron^2/sec ) so the kf and kb of this reaction for these 10 micron compartments are both 0.001/sec.
The basal calcium level in this model is held at 95 nM which is rather close to threshold for the flip to the active state. This is necessary to sustain active propagation of activation.
The stimulus file bis6-propgn_D1e-13_FigEF which was used for the model to replicate Figure 4E and 4F from the paper. | | | This pathway is part of accession 84 and is completely specified in the file acc84.g.
There is no separate for just this pathway. |
| | 14 | MAPK
Pathway No. 934 | Ajay_Bhalla_
2007_ReacDiff3
Accession No. 84 | Network | Molecule = 10
Enzyme = 6
Reaction = 0
| Molecule = 1
Enzyme = 0
Reaction = 0
| Ajay_Bhalla_bistable_model. HFSP Journal. 2007 May;1(1):1-87/
2006-12-08 00:00:00 | | | #132Related Pathway:
6, 24, 35, 56, 61, 75, 139, 142, 182, 193, 211, 230, 317, 335, 352, 366, 371, 377, 384, 390, 396, 402, 403, 409, 415
421, 432, 438, 444, 450, 456, 462, 468, 474, 480, 486, 492, 498, 504, 510, 516, 522, 528, 535, 541, 547, 553, 559, 565
571, 577, 583, 589, 595, 601, 607, 613, 619, 625, 631, 637, 643, 649, 655, 661, 667, 673, 679, 686, 692, 699, 704, 710
716, 722, 728, 734, 740, 746, 752, 758, 764, 770, 776, 782, 788, 794, 800, 806, 812, 818, 824, 830, 836, 842, 848, 854
860, 866, 872, 878, 884, 890, 896, 902, 908, 914, 921, 928, 940, 946, 952, 958, 960, 965, 971, 977, 983, 989, 995
1006, 1012, 1018, 1024, 1030, 1036, 1042, 1048, 1054, 1060, 1066 | | | This is a 25-compartment reaction-diffusion version of the Ajay_Bhalla_2007_bistable model. The original single-compartment model is repeated 25 times.
In addition, a subset (33 out of 50) molecules can diffuse between compartments. Diffusion is implemented as a reaction between corresponding molecules in neighboring compartments. Here D = 1e-13 m^2/sec (i.e., 0.1 micron^2/sec ) so the kf and kb of this reaction for these 10 micron compartments are both 0.001/sec.
The basal calcium level in this model is held at 95 nM which is rather close to threshold for the flip to the active state. This is necessary to sustain active propagation of activation.
The stimulus file bis6-propgn_D1e-13_FigEF which was used for the model to replicate Figure 4E and 4F from the paper. | | | This pathway is part of accession 84 and is completely specified in the file acc84.g.
There is no separate for just this pathway. |
| | 15 | MAPK
Pathway No. 940 | Ajay_Bhalla_
2007_ReacDiff3
Accession No. 84 | Network | Molecule = 10
Enzyme = 6
Reaction = 0
| Molecule = 1
Enzyme = 0
Reaction = 0
| Ajay_Bhalla_bistable_model. HFSP Journal. 2007 May;1(1):1-87/
2006-12-08 00:00:00 | | | #132Related Pathway:
6, 24, 35, 56, 61, 75, 139, 142, 182, 193, 211, 230, 317, 335, 352, 366, 371, 377, 384, 390, 396, 402, 403, 409, 415
421, 432, 438, 444, 450, 456, 462, 468, 474, 480, 486, 492, 498, 504, 510, 516, 522, 528, 535, 541, 547, 553, 559, 565
571, 577, 583, 589, 595, 601, 607, 613, 619, 625, 631, 637, 643, 649, 655, 661, 667, 673, 679, 686, 692, 699, 704, 710
716, 722, 728, 734, 740, 746, 752, 758, 764, 770, 776, 782, 788, 794, 800, 806, 812, 818, 824, 830, 836, 842, 848, 854
860, 866, 872, 878, 884, 890, 896, 902, 908, 914, 921, 928, 934, 946, 952, 958, 960, 965, 971, 977, 983, 989, 995
1006, 1012, 1018, 1024, 1030, 1036, 1042, 1048, 1054, 1060, 1066 | | | This is a 25-compartment reaction-diffusion version of the Ajay_Bhalla_2007_bistable model. The original single-compartment model is repeated 25 times.
In addition, a subset (33 out of 50) molecules can diffuse between compartments. Diffusion is implemented as a reaction between corresponding molecules in neighboring compartments. Here D = 1e-13 m^2/sec (i.e., 0.1 micron^2/sec ) so the kf and kb of this reaction for these 10 micron compartments are both 0.001/sec.
The basal calcium level in this model is held at 95 nM which is rather close to threshold for the flip to the active state. This is necessary to sustain active propagation of activation.
The stimulus file bis6-propgn_D1e-13_FigEF which was used for the model to replicate Figure 4E and 4F from the paper. | | | This pathway is part of accession 84 and is completely specified in the file acc84.g.
There is no separate for just this pathway. |
| | 16 | MAPK
Pathway No. 946 | Ajay_Bhalla_
2007_ReacDiff3
Accession No. 84 | Network | Molecule = 10
Enzyme = 6
Reaction = 0
| Molecule = 1
Enzyme = 0
Reaction = 0
| Ajay_Bhalla_bistable_model. HFSP Journal. 2007 May;1(1):1-87/
2006-12-08 00:00:00 | | | #132Related Pathway:
6, 24, 35, 56, 61, 75, 139, 142, 182, 193, 211, 230, 317, 335, 352, 366, 371, 377, 384, 390, 396, 402, 403, 409, 415
421, 432, 438, 444, 450, 456, 462, 468, 474, 480, 486, 492, 498, 504, 510, 516, 522, 528, 535, 541, 547, 553, 559, 565
571, 577, 583, 589, 595, 601, 607, 613, 619, 625, 631, 637, 643, 649, 655, 661, 667, 673, 679, 686, 692, 699, 704, 710
716, 722, 728, 734, 740, 746, 752, 758, 764, 770, 776, 782, 788, 794, 800, 806, 812, 818, 824, 830, 836, 842, 848, 854
860, 866, 872, 878, 884, 890, 896, 902, 908, 914, 921, 928, 934, 940, 952, 958, 960, 965, 971, 977, 983, 989, 995
1006, 1012, 1018, 1024, 1030, 1036, 1042, 1048, 1054, 1060, 1066 | | | This is a 25-compartment reaction-diffusion version of the Ajay_Bhalla_2007_bistable model. The original single-compartment model is repeated 25 times.
In addition, a subset (33 out of 50) molecules can diffuse between compartments. Diffusion is implemented as a reaction between corresponding molecules in neighboring compartments. Here D = 1e-13 m^2/sec (i.e., 0.1 micron^2/sec ) so the kf and kb of this reaction for these 10 micron compartments are both 0.001/sec.
The basal calcium level in this model is held at 95 nM which is rather close to threshold for the flip to the active state. This is necessary to sustain active propagation of activation.
The stimulus file bis6-propgn_D1e-13_FigEF which was used for the model to replicate Figure 4E and 4F from the paper. | | | This pathway is part of accession 84 and is completely specified in the file acc84.g.
There is no separate for just this pathway. |
| | 17 | MAPK
Pathway No. 952 | Ajay_Bhalla_
2007_ReacDiff3
Accession No. 84 | Network | Molecule = 10
Enzyme = 6
Reaction = 0
| Molecule = 1
Enzyme = 0
Reaction = 0
| Ajay_Bhalla_bistable_model. HFSP Journal. 2007 May;1(1):1-87/
2006-12-08 00:00:00 | | | #132Related Pathway:
6, 24, 35, 56, 61, 75, 139, 142, 182, 193, 211, 230, 317, 335, 352, 366, 371, 377, 384, 390, 396, 402, 403, 409, 415
421, 432, 438, 444, 450, 456, 462, 468, 474, 480, 486, 492, 498, 504, 510, 516, 522, 528, 535, 541, 547, 553, 559, 565
571, 577, 583, 589, 595, 601, 607, 613, 619, 625, 631, 637, 643, 649, 655, 661, 667, 673, 679, 686, 692, 699, 704, 710
716, 722, 728, 734, 740, 746, 752, 758, 764, 770, 776, 782, 788, 794, 800, 806, 812, 818, 824, 830, 836, 842, 848, 854
860, 866, 872, 878, 884, 890, 896, 902, 908, 914, 921, 928, 934, 940, 946, 958, 960, 965, 971, 977, 983, 989, 995
1006, 1012, 1018, 1024, 1030, 1036, 1042, 1048, 1054, 1060, 1066 | | | This is a 25-compartment reaction-diffusion version of the Ajay_Bhalla_2007_bistable model. The original single-compartment model is repeated 25 times.
In addition, a subset (33 out of 50) molecules can diffuse between compartments. Diffusion is implemented as a reaction between corresponding molecules in neighboring compartments. Here D = 1e-13 m^2/sec (i.e., 0.1 micron^2/sec ) so the kf and kb of this reaction for these 10 micron compartments are both 0.001/sec.
The basal calcium level in this model is held at 95 nM which is rather close to threshold for the flip to the active state. This is necessary to sustain active propagation of activation.
The stimulus file bis6-propgn_D1e-13_FigEF which was used for the model to replicate Figure 4E and 4F from the paper. | | | This pathway is part of accession 84 and is completely specified in the file acc84.g.
There is no separate for just this pathway. |
| | 18 | MAPK
Pathway No. 958 | Ajay_Bhalla_
2007_ReacDiff3
Accession No. 84 | Network | Molecule = 10
Enzyme = 6
Reaction = 0
| Molecule = 1
Enzyme = 0
Reaction = 0
| Ajay_Bhalla_bistable_model. HFSP Journal. 2007 May;1(1):1-87/
2006-12-08 00:00:00 | | | #132Related Pathway:
6, 24, 35, 56, 61, 75, 139, 142, 182, 193, 211, 230, 317, 335, 352, 366, 371, 377, 384, 390, 396, 402, 403, 409, 415
421, 432, 438, 444, 450, 456, 462, 468, 474, 480, 486, 492, 498, 504, 510, 516, 522, 528, 535, 541, 547, 553, 559, 565
571, 577, 583, 589, 595, 601, 607, 613, 619, 625, 631, 637, 643, 649, 655, 661, 667, 673, 679, 686, 692, 699, 704, 710
716, 722, 728, 734, 740, 746, 752, 758, 764, 770, 776, 782, 788, 794, 800, 806, 812, 818, 824, 830, 836, 842, 848, 854
860, 866, 872, 878, 884, 890, 896, 902, 908, 914, 921, 928, 934, 940, 946, 952, 960, 965, 971, 977, 983, 989, 995
1006, 1012, 1018, 1024, 1030, 1036, 1042, 1048, 1054, 1060, 1066 | | | This is a 25-compartment reaction-diffusion version of the Ajay_Bhalla_2007_bistable model. The original single-compartment model is repeated 25 times.
In addition, a subset (33 out of 50) molecules can diffuse between compartments. Diffusion is implemented as a reaction between corresponding molecules in neighboring compartments. Here D = 1e-13 m^2/sec (i.e., 0.1 micron^2/sec ) so the kf and kb of this reaction for these 10 micron compartments are both 0.001/sec.
The basal calcium level in this model is held at 95 nM which is rather close to threshold for the flip to the active state. This is necessary to sustain active propagation of activation.
The stimulus file bis6-propgn_D1e-13_FigEF which was used for the model to replicate Figure 4E and 4F from the paper. | | | This pathway is part of accession 84 and is completely specified in the file acc84.g.
There is no separate for just this pathway. |
| | 19 | MAPK
Pathway No. 960 | Ajay_Bhalla_
2007_ReacDiff3
Accession No. 84 | Network | Molecule = 10
Enzyme = 6
Reaction = 0
| Molecule = 1
Enzyme = 0
Reaction = 0
| Ajay_Bhalla_bistable_model. HFSP Journal. 2007 May;1(1):1-87/
2006-12-08 00:00:00 | | | #132Related Pathway:
6, 24, 35, 56, 61, 75, 139, 142, 182, 193, 211, 230, 317, 335, 352, 366, 371, 377, 384, 390, 396, 402, 403, 409, 415
421, 432, 438, 444, 450, 456, 462, 468, 474, 480, 486, 492, 498, 504, 510, 516, 522, 528, 535, 541, 547, 553, 559, 565
571, 577, 583, 589, 595, 601, 607, 613, 619, 625, 631, 637, 643, 649, 655, 661, 667, 673, 679, 686, 692, 699, 704, 710
716, 722, 728, 734, 740, 746, 752, 758, 764, 770, 776, 782, 788, 794, 800, 806, 812, 818, 824, 830, 836, 842, 848, 854
860, 866, 872, 878, 884, 890, 896, 902, 908, 914, 921, 928, 934, 940, 946, 952, 958, 965, 971, 977, 983, 989, 995
1006, 1012, 1018, 1024, 1030, 1036, 1042, 1048, 1054, 1060, 1066 | | | This is a 25-compartment reaction-diffusion version of the Ajay_Bhalla_2007_bistable model. The original single-compartment model is repeated 25 times.
In addition, a subset (33 out of 50) molecules can diffuse between compartments. Diffusion is implemented as a reaction between corresponding molecules in neighboring compartments. Here D = 1e-13 m^2/sec (i.e., 0.1 micron^2/sec ) so the kf and kb of this reaction for these 10 micron compartments are both 0.001/sec.
The basal calcium level in this model is held at 95 nM which is rather close to threshold for the flip to the active state. This is necessary to sustain active propagation of activation.
The stimulus file bis6-propgn_D1e-13_FigEF which was used for the model to replicate Figure 4E and 4F from the paper. | | | This pathway is part of accession 84 and is completely specified in the file acc84.g.
There is no separate for just this pathway. |
| | 20 | MAPK
Pathway No. 965 | Ajay_Bhalla_
2007_ReacDiff3
Accession No. 84 | Network | Molecule = 10
Enzyme = 6
Reaction = 0
| Molecule = 1
Enzyme = 0
Reaction = 0
| Ajay_Bhalla_bistable_model. HFSP Journal. 2007 May;1(1):1-87/
2006-12-08 00:00:00 | | | #132Related Pathway:
6, 24, 35, 56, 61, 75, 139, 142, 182, 193, 211, 230, 317, 335, 352, 366, 371, 377, 384, 390, 396, 402, 403, 409, 415
421, 432, 438, 444, 450, 456, 462, 468, 474, 480, 486, 492, 498, 504, 510, 516, 522, 528, 535, 541, 547, 553, 559, 565
571, 577, 583, 589, 595, 601, 607, 613, 619, 625, 631, 637, 643, 649, 655, 661, 667, 673, 679, 686, 692, 699, 704, 710
716, 722, 728, 734, 740, 746, 752, 758, 764, 770, 776, 782, 788, 794, 800, 806, 812, 818, 824, 830, 836, 842, 848, 854
860, 866, 872, 878, 884, 890, 896, 902, 908, 914, 921, 928, 934, 940, 946, 952, 958, 960, 971, 977, 983, 989, 995
1006, 1012, 1018, 1024, 1030, 1036, 1042, 1048, 1054, 1060, 1066 | | | This is a 25-compartment reaction-diffusion version of the Ajay_Bhalla_2007_bistable model. The original single-compartment model is repeated 25 times.
In addition, a subset (33 out of 50) molecules can diffuse between compartments. Diffusion is implemented as a reaction between corresponding molecules in neighboring compartments. Here D = 1e-13 m^2/sec (i.e., 0.1 micron^2/sec ) so the kf and kb of this reaction for these 10 micron compartments are both 0.001/sec.
The basal calcium level in this model is held at 95 nM which is rather close to threshold for the flip to the active state. This is necessary to sustain active propagation of activation.
The stimulus file bis6-propgn_D1e-13_FigEF which was used for the model to replicate Figure 4E and 4F from the paper. | | | This pathway is part of accession 84 and is completely specified in the file acc84.g.
There is no separate for just this pathway. |
|
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
This Copyright is applied to ensure that the contents of this database remain freely available. Please see FAQ for details. |
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