| |
Reaction
Name | Accession Name /
Accession No. | Pathway Name /
Pathway No. | Kf | Kb | Kd | tau | Reagents |
| 1 | back_1 | AMPAR_traff_
model0
Accession No. 59 | CaMKII
Pathway No. 235 | 0.3
(s^-1) | 0
(uM^-1 s^-1) | Kd(cb) = 0(uM) | - | Substrate:
CaMKII-PSD
Products:
CaMKII
NMDAR
|
| Rates set by the translocation experiments of Shen and Meyer, Science 1999. | | 2 | back_1 | AMPAR_traff_
model1
Accession No. 60 | CaMKII
Pathway No. 245 | 0.3
(s^-1) | 0
(uM^-1 s^-1) | Kd(cb) = 0(uM) | - | Substrate:
CaMKII-PSD
Products:
CaMKII
NMDAR
|
| Rates set by the translocation experiments of Shen and Meyer, Science 1999. | | 3 | back_1 | CaMKII_noPKA_
model3
Accession No. 62 | Shared_Object_
CaMKII_noPKA_
model3
Pathway No. 257 | 0.3
(s^-1) | 0
(uM^-1 s^-1) | Kd(cb) = 0(uM) | - | Substrate:
CaMKII-PSD
Products:
CaMKII
NMDAR
|
| Rates set by the translocation experiments of Shen and Meyer, Science 1999. | | 4 | back_1 | CaMKII_model3
Accession No. 63 | Shared_Object_
CaMKII_model3
Pathway No. 263 | 0.3
(s^-1) | 0
(uM^-1 s^-1) | Kd(cb) = 0(uM) | - | Substrate:
CaMKII-PSD
Products:
CaMKII
NMDAR
|
| Rates set by the translocation experiments of Shen and Meyer, Science 1999. | | 5 | back_1 | AMPAR_CaMKII_
strong_coupling
Accession No. 64 | Shared_Object_
AMPAR_CaMKII_
strong_coupling
Pathway No. 271 | 0.3
(s^-1) | 0
(uM^-1 s^-1) | Kd(cb) = 0(uM) | - | Substrate:
CaMKII-PSD
Products:
CaMKII
NMDAR
|
| Rates set by the translocation experiments of Shen and Meyer, Science 1999. | | 6 | back_1 | AMPAR_CaMKII_
weak_coupling
Accession No. 65 | CaMKII_PSD
Pathway No. 292 | 0.3
(s^-1) | 0
(uM^-1 s^-1) | Kd(cb) = 0(uM) | - | Substrate:
CaMKII-PSD
Products:
CaMKII
NMDAR
|
| Rates set by the translocation experiments of Shen and Meyer, Science 1999. Note that this reaction also incorporates a translocation between compartments of different volumes. | | 7 | back_2 | AMPAR_traff_
model0
Accession No. 59 | CaMKII
Pathway No. 235 | 0.3
(s^-1) | 0
(uM^-1 s^-1) | Kd(cb) = 0(uM) | - | Substrate:
CaMKII-thr305-PS
D
Products:
CaMK-thr305
NMDAR
|
| Same as for back_1 | | 8 | back_2 | AMPAR_traff_
model1
Accession No. 60 | CaMKII
Pathway No. 245 | 0.3
(s^-1) | 0
(uM^-1 s^-1) | Kd(cb) = 0(uM) | - | Substrate:
CaMKII-thr305-PS
D
Products:
CaMK-thr305
NMDAR
|
| Same as for back_1 | | 9 | back_2 | CaMKII_noPKA_
model3
Accession No. 62 | Shared_Object_
CaMKII_noPKA_
model3
Pathway No. 257 | 0.3
(s^-1) | 0
(uM^-1 s^-1) | Kd(cb) = 0(uM) | - | Substrate:
CaMKII-thr305-PS
D
Products:
CaMK-thr305
NMDAR
|
| Same as for back_1 | | 10 | back_2 | CaMKII_model3
Accession No. 63 | Shared_Object_
CaMKII_model3
Pathway No. 263 | 0.3
(s^-1) | 0
(uM^-1 s^-1) | Kd(cb) = 0(uM) | - | Substrate:
CaMKII-thr305-PS
D
Products:
CaMK-thr305
NMDAR
|
| Same as for back_1 | | 11 | back_2 | AMPAR_CaMKII_
strong_coupling
Accession No. 64 | Shared_Object_
AMPAR_CaMKII_
strong_coupling
Pathway No. 271 | 0.3
(s^-1) | 0
(uM^-1 s^-1) | Kd(cb) = 0(uM) | - | Substrate:
CaMKII-thr305-PS
D
Products:
CaMK-thr305
NMDAR
|
| Same as for back_1 | | 12 | back_2 | AMPAR_CaMKII_
weak_coupling
Accession No. 65 | CaMKII_PSD
Pathway No. 292 | 0.3
(s^-1) | 0
(uM^-1 s^-1) | Kd(cb) = 0(uM) | - | Substrate:
CaMKII-thr305-PS
D
Products:
CaMK-thr305
NMDAR
|
| Same as for back_1 | | 13 | basal-activity | fig3_CaMKII
Accession No. 2 | CaMKII
Pathway No. 13 | 0.003
(s^-1) | 0
(s^-1) | - | - | Substrate:
CaMKII
Products:
CaMKII-thr286
|
| 14 | basal-activity | fig4_synapse
Accession No. 3 | CaMKII
Pathway No. 26 | 0.003
(s^-1) | 0
(s^-1) | - | - | Substrate:
CaMKII
Products:
CaMKII-thr286
|
| 15 | basal-activity | Synaptic_
Network
Accession No. 16 | CaMKII
Pathway No. 80 | 0.003
(s^-1) | 0
(s^-1) | - | - | Substrate:
CaMKII
Products:
CaMKII-thr286
|
| This reaction represents one of the unknowns in CaMK-II biochemistry: what maintains the basal level of phosphorylation on thr 286 ? See Hanson and Schulman Ann Rev Biochem 1992 61:559-601, specially pg 580, for review. I have not been able to find any compelling mechanism in the literature, but fortunately the level of basal activity is well documented. Lisman et al propose that the levels of PP1 are very low in the postsynaptic density, and PP2A is excluded from the PSD, and this would lead to autophosphorylation at a sustained level. | | 16 | basal-activity | NonOsc_Ca_
IP3metabolism
Accession No. 23 | CaMKII
Pathway No. 106 | 0.003
(s^-1) | 0
(s^-1) | - | - | Substrate:
CaMKII
Products:
CaMKII-thr286
|
| This reaction represents one of the unknowns in CaMK-II biochemistry: what maintains the basal level of phosphorylation on thr 286 ? See Hanson and Schulman Ann Rev Biochem 1992 61:559-601, specially pg 580, for review. I have not been able to find any compelling mechanism in the literature, but fortunately the level of basal activity is well documented. Lisman et al propose that the levels of PP1 are very low in the postsynaptic density, and PP2A is excluded from the PSD, and this would lead to autophosphorylation at a sustained level. | | 17 | basal-activity | Osc_Ca_
IP3metabolism
Accession No. 24 | CaMKII
Pathway No. 121 | 0.003
(s^-1) | 0
(s^-1) | - | - | Substrate:
CaMKII
Products:
CaMKII-thr286
|
| This reaction represents one of the unknowns in CaMK-II biochemistry: what maintains the basal level of phosphorylation on thr 286 ? See Hanson and Schulman Ann Rev Biochem 1992 61:559-601, specially pg 580, for review. I have not been able to find any compelling mechanism in the literature, but fortunately the level of basal activity is well documented. Lisman et al propose that the levels of PP1 are very low in the postsynaptic density, and PP2A is excluded from the PSD, and this would lead to autophosphorylation at a sustained level. | | 18 | basal-activity | NonOsc_Ca_
IP3metabolism
Accession No. 31 | CaMKII
Pathway No. 145 | 0.003
(s^-1) | 0
(s^-1) | - | - | Substrate:
CaMKII
Products:
CaMKII-thr286
|
| This reaction represents one of the unknowns in CaMK-II biochemistry: what maintains the basal level of phosphorylation on thr 286 ? See Hanson and Schulman Ann Rev Biochem 1992 61:559-601, specially pg 580, for review. I have not been able to find any compelling mechanism in the literature, but fortunately the level of basal activity is well documented. Lisman et al propose that the levels of PP1 are very low in the postsynaptic density, and PP2A is excluded from the PSD, and this would lead to autophosphorylation at a sustained level. | | 19 | basal-activity | Osc_Ca_
IP3metabolism
Accession No. 32 | CaMKII
Pathway No. 159 | 0.003
(s^-1) | 0
(s^-1) | - | - | Substrate:
CaMKII
Products:
CaMKII-thr286
|
| This reaction represents one of the unknowns in CaMK-II biochemistry: what maintains the basal level of phosphorylation on thr 286 ? See Hanson and Schulman Ann Rev Biochem 1992 61:559-601, specially pg 580, for review. I have not been able to find any compelling mechanism in the literature, but fortunately the level of basal activity is well documented. Lisman et al propose that the levels of PP1 are very low in the postsynaptic density, and PP2A is excluded from the PSD, and this would lead to autophosphorylation at a sustained level. | | 20 | basal-activity | CaMKII_2003
Accession No. 49 | CaMKII
Pathway No. 202 | 0.003
(s^-1) | 0
(s^-1) | - | - | Substrate:
CaMKII
Products:
CaMKII-thr286
|
| This reaction represents one of the big unknowns in CaMK-II biochemistry: what maintains the basal level of phosphorylation on thr 286 ? See Hanson and Schulman Ann Rev Biochem 1992 61:559-601, specially pg 580, for review. I have not been able to find any compelling mechanism in the literature, but fortunately the level of basal activity is well documented. |
and 
color.
indicates that ordering is done according to ascending or descending order.